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作者：Medeiros, Hyllana C. D.; Lunt, Sophia Y.
作者单位：Michigan State University; Michigan State University
摘要：Fructose aids tumour growth, but cancer cells usually lack the enzymes needed to metabolize this sugar. The liver converts dietary fructose to lipids that enter the blood, and cancer cells use the lipids to make membranes for proliferation.
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作者：Scholz, Serena R.; Lora, Juan M.
作者单位：Yale University
摘要：Atmospheric rivers (ARs) are narrow regions of intense water vapour transport in the Earth's atmosphere. These transient phenomena carry water from the subtropics to the mid-latitudes and polar regions1,2, making up the majority of polewards moisture transport3, 4-5 and exerting control on the precipitation and water resources in many regions6,7. In addition to transporting moisture, ARs also transport heat, but the impact of this transport on global near-surface air temperatures has not yet b...
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作者：[Anonymous]
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作者：Monje, Michelle; Mahdi, Jasia; Majzner, Robbie; Yeom, Kristen W.; Schultz, Liora M.; Richards, Rebecca M.; Barsan, Valentin; Song, Kun-Wei; Kamens, Jen; Baggott, Christina; Kunicki, Michael; Rietberg, Skyler P.; Lim, Alexandria Sung; Reschke, Agnes; Mavroukakis, Sharon; Egeler, Emily; Moon, Jennifer; Patel, Shabnum; Chinnasamy, Harshini; Erickson, Courtney; Jacobs, Ashley; Duh, Allison K.; Tunuguntla, Ramya; Klysz, Dorota Danuta; Fowler, Carley; Green, Sean; Beebe, Barbara; Carr, Casey; Fujimoto, Michelle; Brown, Annie Kathleen; Petersen, Ann-Louise G.; Mcintyre, Catherine; Siddiqui, Aman; Lepori-Bui, Nadia; Villar, Katlin; Pham, Kymhuynh; Bove, Rachel; Musa, Eric; Reynolds, Warren D.; Kuo, Adam; Prabhu, Snehit; Rasmussen, Lindsey; Cornell, Timothy T.; Partap, Sonia; Fisher, Paul G.; Campen, Cynthia J.; Grant, Gerald; Prolo, Laura; Ye, Xiaobu; Sahaf, Bita; Davis, Kara L.; Feldman, Steven A.; Ramakrishna, Sneha; Mackall, Crystal
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作者：Jung, Jonathan; Zoppe, Simon F.; Soete, Till; Moretti, Simone; Duprey, Nicolas N.; Foreman, Alan D.; Wald, Tanja; Vonhof, Hubert; Haug, Gerald H.; Sigman, Daniel M.; Mulch, Andreas; Schindler, Eberhard; Janussen, Dorte; Martinez-Garcia, Alfredo
作者单位：Max Planck Society; Goethe University Frankfurt; University of Munster; Swiss Federal Institutes of Technology Domain; ETH Zurich; Princeton University; Senckenberg Biodiversitat & Klima- Forschungszentrum (BiK-F); Leibniz Association; Senckenberg Gesellschaft fur Naturforschung (SGN); Leibniz Association; Senckenberg Gesellschaft fur Naturforschung (SGN)
摘要：The ability of stony corals to thrive in the oligotrophic (low-nutrient, low-productivity) surface waters of the tropical ocean is commonly attributed to their symbiotic relationship with photosynthetic dinoflagellates1,2. The evolutionary history of this symbiosis might clarify its organismal and environmental roles3, but its prevalence through time, and across taxa, morphologies and oceanic settings, is currently unclear4-6. Here we report measurements of the nitrogen isotope (15N/14N) ratio...
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作者：Juodzbalis, Ignas; Maiolino, Roberto; Baker, William M.; Tacchella, Sandro; Scholtz, Jan; D'Eugenio, Francesco; Witstok, Joris; Schneider, Raffaella; Trinca, Alessandro; Valiante, Rosa; Decoursey, Christa; Curti, Mirko; Carniani, Stefano; Chevallard, Jacopo; de Graaff, Anna; Arribas, Santiago; Bennett, Jake S.; Bourne, Martin A.; Bunker, Andrew J.; Charlot, Stephane; Jiang, Brian; Koudmani, Sophie; Perna, Michele; Robertson, Brant; Sijacki, Debora; Ubler, Hannah; Williams, Christina C.; Willott, Chris
作者单位：University of Cambridge; University of Cambridge; Sapienza University Rome; Istituto Nazionale Astrofisica (INAF); Sapienza University Rome; University of Arizona; European Southern Observatory; Scuola Normale Superiore di Pisa; University of Oxford; Max Planck Society; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Centro de Astrobiologia (INTA); Harvard University; University of Cambridge; University of Hertfordshire; Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); University of Cambridge; Simons Foundation; Flatiron Institute; University of California System; University of California Santa Cruz; National Research Council Canada
摘要：Recent observations have found a large number of supermassive black holes already in place in the first few hundred million years after the Big Bang, many of which seem to be overmassive relative to their host galaxy stellar mass when compared with local relation1, 2, 3, 4, 5, 6, 7, 8-9. Several different models have been proposed to explain these findings, ranging from heavy seeds to light seeds experiencing bursts of high accretion rate10, 11, 12, 13, 14, 15-16. Yet, current datasets are una...
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作者：[Anonymous]
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作者：Liu, Aoxing; Genovese, Giulio; Zhao, Yajie; Pirinen, Matti; Zekavat, Seyedeh M.; Kentistou, Katherine A.; Yang, Zhiyu; Yu, Kai; Vlasschaert, Caitlyn; Liu, Xiaoxi; Brown, Derek W.; Hudjashov, Georgi; Gorman, Bryan R.; Dennis, Joe; Zhou, Weiyin; Momozawa, Yukihide; Pyarajan, Saiju; Tuzov, Valdislav; Pajuste, Fanny-Dhelia; Aavikko, Mervi; Sipila, Timo P.; Ghazal, Awaisa; Huang, Wen-Yi; Freedman, Neal D.; Song, Lei; Gardner, Eugene J.; Sankaran, Vijay G.; Palotie, Aarno; Ollila, Hanna M.; Tukiainen, Taru; Chanock, Stephen J.; Magi, Reedik; Natarajan, Pradeep; Daly, Mark J.; Bick, Alexander; McCarroll, Steven A.; Terao, Chikashi; Loh, Po-Ru; Ganna, Andrea; Perry, John R. B.; Machiela, Mitchell J.
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作者：Lin, Yiyun; Wang, Junke; Wang, Kaile; Bai, Shanshan; Thennavan, Aatish; Wei, Runmin; Yan, Yun; Li, Jianzhuo; Elgamal, Heba; Sei, Emi; Casasent, Anna; Rao, Mitchell; Tang, Chenling; Multani, Asha S.; Ma, Jin; Montalvan, Jessica; Nagi, Chandandeep; Winocour, Sebastian; Lim, Bora; Thompson, Alastair; Navin, Nicholas
作者单位：University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; Baylor College of Medicine; Baylor College of Medicine; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center
摘要：Aneuploid epithelial cells are common in breast cancer1,2; however, their presence in normal breast tissues is not well understood. To address this question, we applied single-cell DNA sequencing to profile copy number alterations in 83,206 epithelial cells from the breast tissues of 49 healthy women, and we applied single-cell DNA and assay for transposase-accessible chromatin sequencing co-assays to the samples of 19 women. Our data show that all women harboured rare aneuploid epithelial cel...
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作者：Jayakodi, Murukarthick; Lu, Qiongxian; Pidon, Helene; Rabanus-Wallace, M. Timothy; Bayer, Micha; Lux, Thomas; Guo, Yu; Jaegle, Benjamin; Badea, Ana; Bekele, Wubishet; Brar, Gurcharn S.; Braune, Katarzyna; Bunk, Boyke; Chalmers, Kenneth J.; Chapman, Brett; Jorgensen, Morten Egevang; Feng, Jia-Wu; Feser, Manuel; Fiebig, Anne; Gundlach, Heidrun; Guo, Wenbin; Haberer, Georg; Hansson, Mats; Himmelbach, Axel; Hoffie, Iris; Hoffie, Robert E.; Hu, Haifei; Isobe, Sachiko; Koenig, Patrick; Kale, Sandip M.; Kamal, Nadia; Keeble-Gagnere, Gabriel; Keller, Beat; Knauft, Manuela; Koppolu, Ravi; Krattinger, Simon G.; Kumlehn, Jochen; Langridge, Peter; Li, Chengdao; Marone, Marina P.; Maurer, Andreas; Mayer, Klaus F. X.; Melzer, Michael; Muehlbauer, Gary J.; Murozuka, Emiko; Padmarasu, Sudharsan; Perovic, Dragan; Pillen, Klaus; Pin, Pierre A.; Pozniak, Curtis J.; Ramsay, Luke; Pedas, Pai Rosager; Rutten, Twan; Sakuma, Shun; Sato, Kazuhiro; Schueler, Danuta; Schmutzer, Thomas; Scholz, Uwe; Schreiber, Miriam; Shirasawa, Kenta; Simpson, Craig; Skadhauge, Birgitte; Spannagl, Manuel; Steffenson, Brian J.; Thomsen, Hanne C.; Tibbits, Josquin F.; Nielsen, Martin Toft Simmelsgaard; Trautewig, Corinna; Vequaud, Dominique; Voss, Cynthia; Wang, Penghao; Waugh, Robbie; Westcott, Sharon; Rasmussen, Magnus Wohlfahrt; Zhang, Runxuan; Zhang, Xiao-Qi; Wicker, Thomas; Dockter, Christoph; Mascher, Martin; Stein, Nils
作者单位：Leibniz Institut fur Pflanzengenetik und Kulturpflanzenforschung; Institut Agro; INRAE; Centre National de la Recherche Scientifique (CNRS); Universite de Montpellier; James Hutton Institute; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; University of Zurich; Agriculture & Agri Food Canada; Agriculture & Agri Food Canada; University of British Columbia; Leibniz Association; Leibniz Institut fur Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSMZ); University of Adelaide; Murdoch University; Western Crop Genetics Alliance; Lund University; Guangdong Academy of Agricultural Sciences; Kazusa DNA Research Institute; La Trobe University; King Abdullah University of Science & Technology; Department of Primary Industries & Regional Development NSW; Yangtze University; Martin Luther University Halle Wittenberg; Technical University of Munich; University of Minnesota System; University of Minnesota Twin Cities; Julius Kuhn-Institut; University of Saskatchewan; University of Saskatchewan; Tottori University; Okayama University; University of Minnesota System; University of Minnesota Twin Cities; University of Dundee; German Research Foundation (DFG); German Centre for Integrative Biodiversity Research (iDiv); University of Alberta; Aarhus University
摘要：Pangenomes are collections of annotated genome sequences of multiple individuals of a species1. The structural variants uncovered by these datasets are a major asset to genetic analysis in crop plants2. Here we report a pangenome of barley comprising long-read sequence assemblies of 76 wild and domesticated genomes and short-read sequence data of 1,315 genotypes. An expanded catalogue of sequence variation in the crop includes structurally complex loci that are rich in gene copy number variati...
