Nature

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• Facilitate the move of academia from X to Bluesky AI翻译
  作者：Booth, Garrett S.; Jacobs, Jeremy W.; Adkins, Brian D.; Raza, Sheharyar
  作者单位：Vanderbilt University; University of Texas System; University of Texas Southwestern Medical Center; University of Toronto
• HOW A MIGRATORY BIRD POWERS UP TO GO THE DISTANCE AI翻译
  作者：[Anonymous]
• Liquid metal pumps itself out of artificial vasculature AI翻译
  作者：[Anonymous]
• Design tips for studies of brain-behaviour links AI翻译
  作者：Chauvin, Roselyne J.; Dosenbach, Nico U. F.
  作者单位：Washington University (WUSTL); Washington University (WUSTL)
  摘要：Brain-wide association studies, which aim to link features of the brain to a person's characteristics, have a replicability problem. Besides increasing sample size, what else can be done to make these studies more reproducible? Sampling schemes for reproducible brain-wide association studies.
• Virtual lab powered by 'AI scientists' super-charges biomedical research AI翻译
  作者：Kudiabor, Helena
• Single-molecule states link transcription factor binding to gene expression AI翻译
  作者：Doughty, Benjamin R.; Hinks, Michaela M.; Schaepe, Julia M.; Marinov, Georgi K.; Thurm, Abby R.; Rios-Martinez, Carolina; Parks, Benjamin E.; Tan, Yingxuan; Marklund, Emil; Dubocanin, Danilo; Bintu, Lacramioara; Greenleaf, William J.
  作者单位：Stanford University; Stanford University; Stanford University; Stanford University; Stockholm University; Stanford University
  摘要：The binding of multiple transcription factors (TFs) to genomic enhancers drives gene expression in mammalian cells1. However, the molecular details that link enhancer sequence to TF binding, promoter state and transcription levels remain unclear. Here we applied single-molecule footprinting2,3 to measure the simultaneous occupancy of TFs, nucleosomes and other regulatory proteins on engineered enhancer-promoter constructs with variable numbers of TF binding sites for both a synthetic TF and an...
• Transmission of a human isolate of clade 2.3.4.4b A(H5N1) virus in ferrets AI翻译
  作者：Pulit-Penaloza, Joanna A.; Belser, Jessica A.; Brock, Nicole; Kieran, Troy J.; Sun, Xiangjie; Pappas, Claudia; Zeng, Hui; Carney, Paul; Chang, Jessie; Bradley-Ferrell, Brandon; Stevens, James; de la Cruz, Juan A.; Hatta, Yasuko; Di, Han; Davis, C. Todd; Tumpey, Terrence M.; Maines, Taronna R.
  作者单位：Centers for Disease Control & Prevention - USA; CDC National Center for Immunization & Respiratory Diseases (NCIRD)
  摘要：Since 2020, there has been unprecedented global spread of highly pathogenic avian influenza A(H5N1) in wild bird populations with spillover into a variety of mammalian species and sporadically humans1. In March 2024, clade 2.3.4.4b A(H5N1) virus was first detected in dairy cattle in the USA, with subsequent detection in numerous states2, leading to more than a dozen confirmed human cases3,4. In this study, we used the ferret, a well-characterized animal model that permits concurrent investigat...
• 'That's funny': creative solutions for time-starved researchers AI翻译
  作者：Tregoning, John; Tillotson, Richard
  作者单位：Imperial College London
• Autoregulation in rats with transplanted supernumerary kidneys (vol 284, pg 618, 1980) AI翻译
  作者：Gittes, Ruben F.; Rist, Marcus; Treves, Salvador; Biewener, Andrew
  作者单位：Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Boston Children's Hospital
• Automated real-world data integration improves cancer outcome prediction AI翻译
  作者：Jee, Justin; Fong, Christopher; Pichotta, Karl; Tran, Thinh Ngoc; Luthra, Anisha; Waters, Michele; Fu, Chenlian; Altoe, Mirella; Liu, Si-Yang; Maron, Steven B.; Ahmed, Mehnaj; Kim, Susie; Pirun, Mono; Chatila, Walid K.; de Bruijn, Ino; Pasha, Arfath; Kundra, Ritika; Gross, Benjamin; Mastrogiacomo, Brooke; Aprati, Tyler J.; Liu, David; Gao, Jianjiong; Capelletti, Marzia; Pekala, Kelly; Loudon, Lisa; Perry, Maria; Bandlamudi, Chaitanya; Donoghue, Mark; Satravada, Baby Anusha; Martin, Axel; Shen, Ronglai; Chen, Yuan; Brannon, A. Rose; Chang, Jason; Braunstein, Lior; Li, Anyi; Safonov, Anton; Stonestrom, Aaron; Sanchez-Vela, Pablo; Wilhelm, Clare; Robson, Mark; Scher, Howard; Ladanyi, Marc; Reis-Filho, Jorge S.; Solit, David B.; Jones, David R.; Gomez, Daniel; Yu, Helena; Chakravarty, Debyani; Yaeger, Rona; Abida, Wassim; Park, Wungki; O'Reilly, Eileen M.; Garcia-Aguilar, Julio; Socci, Nicholas; Sanchez-Vega, Francisco; Carrot-Zhang, Jian; Stetson, Peter D.; Levine, Ross; Rudin, Charles M.; Berger, Michael F.; Shah, Sohrab P.; Schrag, Deborah; Razavi, Pedram; Kehl, Kenneth L.; Li, Bob T.; Riely, Gregory J.; Schultz, Nikolaus; MSK Canc Data Sci Initiative Grp, Aaron
  作者单位：Memorial Sloan Kettering Cancer Center; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Cornell University; Weill Cornell Medicine
  摘要：The digitization of health records and growing availability of tumour DNA sequencing provide an opportunity to study the determinants of cancer outcomes with unprecedented richness. Patient data are often stored in unstructured text and siloed datasets. Here we combine natural language processing annotations1,2 with structured medication, patient-reported demographic, tumour registry and tumour genomic data from 24,950 patients at Memorial Sloan Kettering Cancer Center to generate a clinicogen...