Nature

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• Father time: the physicist on a mission to build the world's first nuclear clock AI翻译
  作者：Gibney, Elizabeth
• Programmable enzymes for large genome edits AI翻译
  作者：[Anonymous]
• Stereochemistry in the disorder-order continuum of protein interactions AI翻译
  作者：Newcombe, Estella A.; Due, Amanda D.; Sottini, Andrea; Elkjaer, Steffie; Theisen, Frederik Friis; Fernandes, Catarina B.; Staby, Lasse; Delaforge, Elise; Bartling, Christian R. O.; Brakti, Inna; Bugge, Katrine; Schuler, Benjamin; Skriver, Karen; Olsen, Johan G.; Kragelund, Birthe B.
  作者单位：University of Copenhagen; University of Copenhagen; University of Copenhagen; University of Zurich; University of Zurich; University of Copenhagen
  摘要：Intrinsically disordered proteins can bind via the formation of highly disordered protein complexes without the formation of three-dimensional structure1. Most naturally occurring proteins are levorotatory (l)-that is, made up only of l-amino acids-imprinting molecular structure and communication with stereochemistry2. By contrast, their mirror-image dextrorotatory (d)-amino acids are rare in nature. Whether disordered protein complexes are truly independent of chiral constraints is not clear....
• A human isolate of bovine H5N1 is transmissible and lethal in animal models AI翻译
  作者：Gu, Chunyang; Maemura, Tadashi; Guan, Lizheng; Eisfeld, Amie J.; Biswas, Asim; Kiso, Maki; Uraki, Ryuta; Ito, Mutsumi; Trifkovic, Sanja; Wang, Tong; Babujee, Lavanya; Presler Jr, Robert; Dahn, Randall; Suzuki, Yasuo; Halfmann, Peter J.; Yamayoshi, Seiya; Neumann, Gabriele; Kawaoka, Yoshihiro
  作者单位：University of Wisconsin System; University of Wisconsin Madison; University of Tokyo; University of Shizuoka; University of Tokyo; Japan Institute for Health Security (JIHS); National Center for Global Health & Medicine - Japan
  摘要：The outbreak of clade 2.3.4.4b highly pathogenic avian influenza viruses of the H5N1 subtype (HPAI H5N1) in dairy cattle in the USA has so far resulted in spillover infections of at least 14 farm workers1, 2-3, who presented with mild respiratory symptoms or conjunctivitis, and one individual with no known animal exposure who was hospitalized but recovered3,4. Here we characterized A/Texas/37/2024 (huTX37-H5N1), a virus isolated from the eyes of an infected farm worker who developed conjunctiv...
• How fast is the Universe expanding? This astronomer took cosmology closer to an answer AI翻译
  作者：Castelvecchi, Davide
• How climate change is changing calendars - and what to do about it AI翻译
  作者：Yu, Haoxuan; van de Pas, Remco; Stanojev, Jermina
  作者单位：KU Leuven
• 229ThF4 thin films for solid-state nuclear clocks AI翻译
  作者：Zhang, Chuankun; von der Wense, Lars; Doyle, Jack F.; Higgins, Jacob S.; Ooi, Tian; Friebel, Hans U.; Ye, Jun; Elwell, R.; Terhune, J. E. S.; Morgan, H. W. T.; Alexandrova, A. N.; Tan, H. B. Tran; Derevianko, Andrei; Hudson, Eric R.
  作者单位：National Institute of Standards & Technology (NIST) - USA; University of Colorado System; University of Colorado Boulder; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of Manchester; Nevada System of Higher Education (NSHE); University of Nevada Reno; United States Department of Energy (DOE); Los Alamos National Laboratory; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; Johannes Gutenberg University of Mainz
  摘要：After nearly 50 years of searching, the vacuum ultraviolet 229Th nuclear isomeric transition has recently been directly laser excited1,2 and measured with high spectroscopic precision3. Nuclear clocks based on this transition are expected to be more robust4,5 than and may outperform6,7 current optical atomic clocks. These clocks also promise sensitive tests for new physics beyond the standard model5,8, 9, 10, 11-12. In light of these important advances and applications, a substantial increase ...
• Fungal symbiont transmitted by free-living mice promotes type 2 immunity AI翻译
  作者：Liao, Yun; Gao, Iris H.; Kusakabe, Takato; Lin, Woan-Yu; Grier, Alexander; Pan, Xiangyu; Morzhanaeva, Olga; Shea, Terrance P.; Yano, Hiroshi; Karo-Atar, Danielle; Olsen, Kaitlin A.; Oh, Ji Hoon; Vandegrift, Kurt J.; King, Irah L.; Cuomo, Christina A.; Artis, David; Rehermann, Barbara; Lipman, Neil; Iliev, Iliyan D.
  作者单位：Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; McGill University; McGill University; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK); Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Brown University; Memorial Sloan Kettering Cancer Center; Cornell University; Weill Cornell Medicine
  摘要：The gut mycobiota is crucial for intestinal homeostasis and immune function1. Yet its variability and inconsistent fungal colonization of laboratory mice hinders the study of the evolutionary and immune processes that underpin commensalism2,3. Here, we show that Kazachstania pintolopesii is a fungal commensal in wild urban and rural mice, with an exceptional ability to colonize the mouse gastrointestinal tract and dominate the gut mycobiome. Kazachstania pintolopesii colonization occurs in a b...
• This fearless science sleuth risked her career to expose publication fraud AI翻译
  作者：Else, Holly
• Strategic joints halt building collapse AI翻译
  作者：[Anonymous]