作者：Kang, Kaidi; Seidlitz, Jakob; Bethlehem, Richard A. I.; Xiong, Jiangmei; Jones, Megan T.; Mehta, Kahini; Keller, Arielle S.; Tao, Ran; Randolph, Anita; Larsen, Bart; Tervo-Clemmens, Brenden; Feczko, Eric; Dominguez, Oscar Miranda; Nelson, Steven M.; Schildcrout, Jonathan; Fair, Damien A.; Satterthwaite, Theodore D.; Alexander-Bloch, Aaron F.; Vandekar, Simon
作者单位：Vanderbilt University; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Pennsylvania Medicine; University of Cambridge; University of Pennsylvania; University of Connecticut; University of Connecticut; Vanderbilt University; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities
摘要：Brain-wide association studies (BWAS) are a fundamental tool in discovering brain-behaviour associations1,2. Several recent studies have shown that thousands of study participants are required for good replicability of BWAS1-3. Here we performed analyses and meta-analyses of a robust effect size index using 63 longitudinal and cross-sectional MRI studies from the Lifespan Brain Chart Consortium4 (77,695 total scans) to demonstrate that optimizing study design is critical for increasing standar...
作者：Noble, Suzanne
作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco
作者：Fowle-Grider, Ronald; Rowles, Joe L.; Shen, Isabel; Wang, Yahui; Schwaiger-Haber, Michaela; Dunham, Alden J.; Jayachandran, Kay; Inkman, Matthew; Zahner, Michael; Naser, Fuad J.; Jackstadt, Madelyn M.; Spalding, Jonathan L.; Chiang, Sarah; Mccommis, Kyle S.; Dolle, Roland E.; Kramer, Eva T.; Zimmerman, Sarah M.; Souroullas, George P.; Finck, Brian N.; Shriver, Leah P.; Kaufman, Charles K.; Schwarz, Julie K.; Zhang, Jin; Patti, Gary J.
作者单位：Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Saint Louis University; Siteman Cancer Center; Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL)
摘要：Fructose consumption has increased considerably over the past five decades, largely due to the widespread use of high-fructose corn syrup as a sweetener1. It has been proposed that fructose promotes the growth of some tumours directly by serving as a fuel2,3. Here we show that fructose supplementation enhances tumour growth in animal models of melanoma, breast cancer and cervical cancer without causing weight gain or insulin resistance. The cancer cells themselves were unable to use fructose r...
