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作者：[Anonymous]
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作者：Mondal, Anish Kumar; Carrillo, Elisa; Jayaraman, Vasanthi; Twomey, Edward C.
作者单位：Johns Hopkins University; Johns Hopkins University; University of Texas System; University of Texas Health Science Center Houston; University of Texas System; UTMD Anderson Cancer Center; University of Texas Health Science Center Houston; Johns Hopkins University
摘要：Ionotropic glutamate receptors (iGluRs) are tetrameric ligand-gated ion channels that mediate most excitatory neurotransmission1. iGluRs are gated by glutamate, where on glutamate binding, they open their ion channels to enable cation influx into postsynaptic neurons, initiating signal transduction1,2. The structural mechanics of how glutamate gating occurs in full-length iGluRs is not well understood. Here, using the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid subtype iGluR (AMPA...
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作者：He, Linqiang; Zhou, Tianjun; Guo, Zhun
作者单位：Chinese Academy of Sciences; Institute of Atmospheric Physics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Columbia University; Chinese Academy of Sciences; Institute of Atmospheric Physics, CAS
摘要：In the future, monsoon rainfall over densely populated South Asia is expected to increase, even as monsoon circulation weakens1, 2-3. By contrast, past warm intervals were marked by both increased rainfall and a strengthening of monsoon circulation4, 5-6, posing a challenge to understanding the response of the South Asian summer monsoon to warming. Here we show consistent South Asian summer monsoon changes in the mid-Pliocene, Last Interglacial, mid-Holocene and future scenarios, characterized...
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作者：O'Callaghan, Jonathan
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作者：Brock, Benjamin L.; Singh, Shraddha; Eickbusch, Alec; Sivak, Volodymyr V.; Ding, Andy Z.; Frunzio, Luigi; Girvin, Steven M.; Devoret, Michel H.
作者单位：Yale University; Yale University; Yale University; Alphabet Inc.; Google Incorporated; University of California System; University of California Santa Barbara; University of California System; University of California Santa Barbara
摘要：Hilbert space dimension is a key resource for quantum information processing(1,2). Not only is a large overall Hilbert space an essential requirement for quantum error correction, but a large local Hilbert space can also be advantageous for realizing gates and algorithms more efficiently(3, 4, 5, 6-7). As a result, there has been considerable experimental effort in recent years to develop quantum computing platforms using qudits (d-dimensional quantum systems with d > 2) as the fundamental uni...
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作者：Dennis, Donovan
作者单位：Potsdam Institut fur Klimafolgenforschung
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作者：Kwon, Diana
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作者：Xie, Chen; Chen, Christine H.; Lisse, Carey M.; Hines, Dean C.; Beck, Tracy; Betti, Sarah K.; Pinilla-Alonso, Noemi; Ingebretsen, Carl; Worthen, Kadin; Gaspar, Andras; Wolff, Schuyler G.; Bolin, Bryce T.; Pueyo, Laurent; Perrin, Marshall D.; Stansberry, John A.; Leisenring, Jarron M.
作者单位：Johns Hopkins University; Space Telescope Science Institute; Johns Hopkins University; Johns Hopkins University Applied Physics Laboratory; University of Oviedo; State University System of Florida; University of Central Florida; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; Eureka Scientific
摘要：Debris disks are exoplanetary systems that contain planets, minor bodies (asteroids, Kuiper belt objects, comets and so on) and micrometre-sized debris dust1. Because water ice is the most common frozen volatile, it plays an essential role in the formation of planets2,3 and minor bodies. Although water ice has been commonly found in Kuiper belt objects and comets in the Solar System4, no definitive evidence for water ice in debris disks has been obtained to date1. Here we report the discovery ...
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作者：Vicanolo, Tommaso; Ozcan, Alaz; Li, Jackson LiangYao; Huerta-Lopez, Carla; Ballesteros, Ivan; Rubio-Ponce, Andrea; Dumitru, Andra C.; Nicolas-avila, Jose angel; Molina-Moreno, Miguel; Reyes-Gutierrez, Pablo; Johnston, Andrew D.; Martone, Catherine; Greto, Eric; Quilez-Alvarez, Antonio; Calvo, Enrique; Bonzon-Kulichenko, Elena; alvarez-Velez, Rebeca; Chooi, Ming Yao; Kwok, Immanuel; Gonzalez-Bermudez, Blanca; Malleret, Benoit; Espinosa, Francisco M.; Zhang, Ming; Wang, Yu-Long; Sun, Dasheng; Chong, Shu Zhen; El-Armouche, Ali; Kim, Kevin K.; Udalova, Irina A.; Greco, Valentina; Garcia, Ricardo; Vazquez, Jesus; Dopazo, Ana; Plaza, Gustavo R.; Alegre-Cebollada, Jorge; Uderhardt, Stefan; Ng, Lai Guan; Hidalgo, Andres
作者单位：Centro Nacional de Investigaciones Cardiovasculares (CNIC); Yale University; Yale University; Agency for Science Technology & Research (A*STAR); A*STAR - Singapore Immunology Network (SIgN); Universidad Carlos III de Madrid; Yale University; Yale University; University of Erlangen Nuremberg; Universidad de Castilla-La Mancha; National University of Singapore; Universidad Politecnica de Madrid; Centro de Tecnologia Biomedica (CTB); Universidad Politecnica de Madrid; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Ciencia de Materiales de Madrid (ICMM); Shanghai Jiao Tong University; Fudan University; Shanghai Jiao Tong University; Technische Universitat Dresden; University of Michigan System; University of Michigan; University of Oxford; Kennedy Institute for Rheumatology; CIBER - Centro de Investigacion Biomedica en Red; CIBERCV; Shanghai Jiao Tong University
摘要：Defence from environmental threats is provided by physical barriers that confer mechanical protection and prevent the entry of microorganisms1. If microorganisms overcome those barriers, however, innate immune cells use toxic chemicals to kill the invading cells2,3. Here we examine immune diversity across tissues and identify a population of neutrophils in the skin that expresses a broad repertoire of proteins and enzymes needed to build the extracellular matrix. In the naive skin, these matri...
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作者：Fieldhouse, Rachel
