Matrix-producing neutrophils populate and shield the skin

• 成果类型: Article
• 署名作者: Vicanolo, Tommaso; Ozcan, Alaz; Li, Jackson LiangYao; Huerta-Lopez, Carla; Ballesteros, Ivan; Rubio-Ponce, Andrea; Dumitru, Andra C.; Nicolas-avila, Jose angel; Molina-Moreno, Miguel; Reyes-Gutierrez, Pablo; Johnston, Andrew D.; Martone, Catherine; Greto, Eric; Quilez-Alvarez, Antonio; Calvo, Enrique; Bonzon-Kulichenko, Elena; alvarez-Velez, Rebeca; Chooi, Ming Yao; Kwok, Immanuel; Gonzalez-Bermudez, Blanca; Malleret, Benoit; Espinosa, Francisco M.; Zhang, Ming; Wang, Yu-Long; Sun, Dasheng; Chong, Shu Zhen; El-Armouche, Ali; Kim, Kevin K.; Udalova, Irina A.; Greco, Valentina; Garcia, Ricardo; Vazquez, Jesus; Dopazo, Ana; Plaza, Gustavo R.; Alegre-Cebollada, Jorge; Uderhardt, Stefan; Ng, Lai Guan; Hidalgo, Andres
• 署名单位: Centro Nacional de Investigaciones Cardiovasculares (CNIC); Yale University; Yale University; Agency for Science Technology & Research (A*STAR); A*STAR - Singapore Immunology Network (SIgN); Universidad Carlos III de Madrid; Yale University; Yale University; University of Erlangen Nuremberg; Universidad de Castilla-La Mancha; National University of Singapore; Universidad Politecnica de Madrid; Centro de Tecnologia Biomedica (CTB); Universidad Politecnica de Madrid; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Ciencia de Materiales de Madrid (ICMM); Shanghai Jiao Tong University; Fudan University; Shanghai Jiao Tong University; Technische Universitat Dresden; University of Michigan System; University of Michigan; University of Oxford; Kennedy Institute for Rheumatology; CIBER - Centro de Investigacion Biomedica en Red; CIBERCV; Shanghai Jiao Tong University
• 刊物名称: Nature
• ISSN/ISSBN: 0028-2367
• DOI: 10.1038/s41586-025-08741-5
• 发表日期: 2025-05-15
• 关键词: tgf-beta; extracellular-matrix; modulation; responses; immunity; DEFENSE; biology; cxcr4

摘要

Defence from environmental threats is provided by physical barriers that confer mechanical protection and prevent the entry of microorganisms1. If microorganisms overcome those barriers, however, innate immune cells use toxic chemicals to kill the invading cells2,3. Here we examine immune diversity across tissues and identify a population of neutrophils in the skin that expresses a broad repertoire of proteins and enzymes needed to build the extracellular matrix. In the naive skin, these matrix-producing neutrophils contribute to the composition and structure of the extracellular matrix, reinforce its mechanical properties and promote barrier function. After injury, these neutrophils build 'rings' of matrix around wounds, which shield against foreign molecules and bacteria. This structural program relies on TGF beta signalling; disabling the TGF beta receptor in neutrophils impaired ring formation around wounds and facilitated bacterial invasion. We infer that the innate immune system has evolved diverse strategies for defence, including one that physically shields the host from the outside world.