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作者：Guglielmi, Giorgia; Naddaf, Miryam; Fieldhouse, Rachel
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作者：Jacobs, Jeremy W.; Booth, Garrett S.
作者单位：Vanderbilt University
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作者：Takei, Yodai; Yang, Yujing; White, Jonathan; Goronzy, Isabel N.; Yun, Jina; Prasad, Meera; Ombelets, Lincoln J.; Schindler, Simone; Bhat, Prashant; Guttman, Mitchell; Cai, Long
作者单位：California Institute of Technology; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Washington University (WUSTL)
摘要：The mammalian nucleus is compartmentalized by diverse subnuclear structures. These subnuclear structures, marked by nuclear bodies and histone modifications, are often cell-type specific and affect gene regulation and 3D genome organization1, 2-3. Understanding their relationships rests on identifying the molecular constituents of subnuclear structures and mapping their associations with specific genomic loci and transcriptional levels in individual cells, all in complex tissues. Here, we intr...
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作者：Orr, Michael C.; Ascher, John S.; Pickering, John
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作者：Peixoto, Raquel S.
作者单位：King Abdullah University of Science & Technology
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作者：Bourzac, Katherine
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作者：[Anonymous]
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作者：Rounge, Trine B.; Paulsen, Jonas
作者单位：University of Oslo; University of Oslo; Norwegian Institute of Public Health (NIPH); University of Oslo
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作者：Luo, Cihang; Parry, Luke A.; Boudinot, Brendon E.; Wang, Shengyu; Jarzembowski, Edmund A.; Zhang, Haichun; Wang, Bo
作者单位：Chinese Academy of Sciences; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Leibniz Association; Senckenberg Gesellschaft fur Naturforschung (SGN); University of Oxford; Natural History Museum London
摘要：Acanthocephala (thorny-headed worms), characterized by the presence of an eversible proboscis with hooks, are a diverse endoparasitic group that infect a wide range of vertebrates and invertebrates1. Although long regarded as a separate phylum, they have several putative sister taxa based on morphological features, including Platyhelminthes (flatworms)2, Priapulida (penis worms)3 and Rotifera (wheel animals)4. Molecular phylogenies have instead recovered them within rotifers5, 6, 7, 8, 9-10, s...
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作者：Ducoli, Luca; Zarnegar, Brian J.; Porter, Douglas F.; Meyers, Robin M.; Miao, Weili; Riley, Nicholas M.; Srinivasan, Suhas; Jackrazi, Leandra V.; Yang, Yen-Yu; Li, Zhouxian; Wang, Yinsheng; Bertozzi, Carolyn R.; Flynn, Ryan A.; Khavari, Paul A.
作者单位：Stanford University; Stanford University; Howard Hughes Medical Institute; Stanford University; University of California System; University of California Riverside; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University; Stanford University; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Palo Alto Health Care System
摘要：RNA-binding proteins (RBPs) control varied processes, including RNA splicing, stability, transport and translation1, 2-3. Dysfunctional RNA-RBP interactions contribute to the pathogenesis of human disease1,4,5; however, characterizing the nature and dynamics of multiprotein assemblies on RNA has been challenging. Here, to address this, non-isotopic ligation-based ultraviolet-light-induced cross-linking and immunoprecipitation6 was combined with mass spectrometry (irCLIP-RNP) to identify RNA-de...
