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作者：Kapadia, Chiraag D.; Williams, Nicholas; Dawson, Kevin J.; Watson, Caroline; Yousefzadeh, Matthew J.; Le, Duy; Nyamondo, Kudzai; Kodavali, Sreeya; Cagan, Alex; Waldvogel, Sarah; Zhang, Xiaoyan; de la Fuente, Josephine; Leongamornlert, Daniel; Mitchell, Emily; Florez, Marcus A.; Sosnowski, Krzysztof; Aguilar, Rogelio; Martell, Alejandra; Guzman, Anna; Harrison, David; Niedernhofer, Laura J.; King, Katherine Y.; Campbell, Peter J.; Blundell, Jamie; Goodell, Margaret A.; Nangalia, Jyoti
作者单位：Baylor College of Medicine; Wellcome Trust Sanger Institute; University of Cambridge; University of Minnesota System; University of Minnesota Twin Cities; Columbia University; Baylor College of Medicine; University of Cambridge; University of Cambridge; Jackson Laboratory
摘要：Haematopoietic stem cells maintain blood production throughout life1. Although extensively characterized using the laboratory mouse, little is known about clonal selection and population dynamics of the haematopoietic stem cell pool during murine ageing. We isolated stem cells and progenitors from young and old mice, identifying 221,890 somatic mutations genome-wide in 1,845 single-cell-derived colonies. Mouse stem cells and progenitors accrue approximately 45 somatic mutations per year, a rat...
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作者：Dolgin, Elie
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作者：Zhong, Yifan
作者单位：University of Western Australia
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作者：Zhang, Yiran; Shavit, Gal; Ma, Huiyang; Han, Youngjoon; Siu, Chi Wang; Mukherjee, Ankan; Watanabe, Kenji; Taniguchi, Takashi; Hsieh, David; Lewandowski, Cyprian; von Oppen, Felix; Oreg, Yuval; Nadj-Perge, Stevan
作者单位：California Institute of Technology; California Institute of Technology; California Institute of Technology; California Institute of Technology; State University System of Florida; Florida State University; State University System of Florida; Florida State University; National Institute for Materials Science; Free University of Berlin; Free University of Berlin; Weizmann Institute of Science
摘要：The relative twist angle between layers of near-lattice-matched van der Waals materials is critical for the emergent phenomena associated with moir & eacute; flat bands1, 2-3. However, the concept of angle rotation control is not exclusive to moir & eacute; superlattices in which electrons directly experience a twist-angle-dependent periodic potential. Instead, it can also be used to induce programmable symmetry-breaking perturbations with the goal of stabilizing desired correlated states. Her...
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作者：Tian, Yuan; Feng, Tingting; Zhang, Jun; Meng, Qingren; Zhan, Wenxin; Tang, Ming; Liu, Chaohua; Li, Mengyan; Tao, Wenhui; Shu, Yuxin; Zhang, Yu; Chen, Feng; Takeda, Shunichi; Zhu, Qian; Lu, Xiaopeng; Zhu, Wei-Guo
作者单位：Shenzhen University; Tongji University; Fudan University; Wannan Medical College; Peking University
摘要：The formation of accessible chromatin around DNA double-strand breaks is essential for their efficient repair1. Although the linker histone H1 is known to facilitate higher-order chromatin compaction2,3, the mechanisms by which H1 modifications regulate chromatin relaxation in response to DNA damage are unclear. Here we show that CTP synthase 1 (CTPS1)-catalysed deamidation of H1 asparagine residues 76 and 77 triggers the sequential acetylation of lysine 75 following DNA damage, and this dual ...
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作者：Kimura, Kimitoshi; Subramanian, Ayshwarya; Yin, Zhuoran; Khalilnezhad, Ahad; Wu, Yufan; He, Danyang; Dixon, Karen O.; Chitta, Udbhav Kasyap; Ding, Xiaokai; Adhikari, Niraj; Guzchenko, Isabell; Zhang, Xiaoming; Tang, Ruihan; Pertel, Thomas; Myers, Samuel A.; Aastha, Aastha; Nomura, Masashi; Eskandari-Sedighi, Ghazaleh; Singh, Vasundhara; Liu, Lei; Lambden, Conner; Kleemann, Kilian L.; Gupta, Neha; Barry, Jen-Li; Durao, Ana; Cheng, Yiran; Silveira, Sebastian; Zhang, Huiyuan; Suhail, Aamir; Delorey, Toni; Rozenblatt-Rosen, Orit; Freeman, Gordon J.; Selkoe, Dennis J.; Weiner, Howard L.; Blurton-Jones, Mathew; Cruchaga, Carlos; Regev, Aviv; Suva, Mario L.; Butovsky, Oleg; Kuchroo, Vijay K.
作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Kyoto University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Massachusetts Eye & Ear Infirmary; Harvard Medical School; La Jolla Institute for Immunology; University of California System; University of California San Diego; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; University of California System; University of California Irvine; University of California System; University of California Irvine; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; University of California System; University of California Irvine; Washington University (WUSTL); Washington University (WUSTL); Roche Holding; Roche Holding USA; Genentech
摘要：Microglia are the resident immune cells in the brain and have pivotal roles in neurodevelopment and neuroinflammation1,2. This study investigates the function of the immune-checkpoint molecule TIM-3 (encoded by HAVCR2) in microglia. TIM-3 was recently identified as a genetic risk factor for late-onset Alzheimer's disease3, and it can induce T cell exhaustion4. However, its specific function in brain microglia remains unclear. We demonstrate in mouse models that TGF beta signalling induces TIM-...
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作者：Fanourakis, Alexander; Ali, Yahia; Chen, Liao; Kelly, Patrick Q.; Bracken, Abigail J.; Kelly, Christopher B.; Levin, Mark D.
作者单位：University of Chicago
摘要：Pyrazoles are heterocycles commonly found as key substructures in agrochemicals and medicinally active compounds alike1,2. Despite their pervasiveness, established methods fall notably short in delivering complex pyrazoles selectively due to issues of differentiation during either assembly or N-functionalization3. This is a direct consequence of a dominant synthetic strategy that attempts to control selectivity-determining bonds between poorly differentiated starting materials. To overcome thi...
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作者：Patterson, Caitlin L.; Sheekey, Owen I.; Arp, Trevor B.; Holleis, Ludwig F. W.; Koh, Jin Ming; Choi, Youngjoon; Xie, Tian; Xu, Siyuan; Guo, Yi; Stoyanov, Hari; Redekop, Evgeny; Zhang, Canxun; Babikyan, Grigory; Gong, David; Zhou, Haoxin; Cheng, Xiang; Taniguchi, Takashi; Watanabe, Kenji; Huber, Martin E.; Jin, Chenhao; Lantagne-Hurtubise, Etienne; Alicea, Jason; Young, Andrea F.
作者单位：University of California System; University of California Santa Barbara; California Institute of Technology; Harvard University; University of California System; University of California Berkeley; National Institute for Materials Science; National Institute for Materials Science; Children's Hospital Colorado; University of Colorado System; University of Colorado Denver; University of Colorado Anschutz Medical Campus; California Institute of Technology; University of Sherbrooke; University of Sherbrooke; California Institute of Technology
摘要：Graphene and transition metal dichalcogenide flat-band systems show similar phase diagrams, replete with magnetic1, 2, 3, 4-5 and superconducting6, 7, 8, 9, 10-11 phases. An abiding question has been whether magnetic ordering competes with superconductivity or facilitates pairing. For example, recent studies of Bernal bilayer graphene in the presence of enhanced spin-orbit coupling show a substantial increase in the observed domain and critical temperature Tc of superconducting states12, 13-14...
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作者：Du, Feng; Drozdov, Alexander P.; Minkov, Vasily S.; Balakirev, Fedor F.; Kong, Panpan; Smith, G. Alexander; Yan, Jiafeng; Shen, Bin; Gegenwart, Philipp; Eremets, Mikhail I.
作者单位：Max Planck Society; United States Department of Energy (DOE); Los Alamos National Laboratory; Chinese Academy of Sciences; Institute of Physics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Hanyang University; University of Augsburg
摘要：Several hydrogen-rich superconductors have been found to show unprecedentedly high critical temperatures1, 2, 3-4, stimulating investigations into the nature of the superconductivity in these materials. Although their macroscopic superconducting properties are established1,5, 6-7, microscopic insights into the pairing mechanism remains unclear. Here we characterize the superconducting gap structure in the high-temperature superconductor H3S and its deuterium counterpart D3S by performing tunne...
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作者：Biever, Celeste
