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作者：Tabar, V.; Sarva, H.; Lozano, A. M.; Fasano, A.; Kalia, S. K.; Yu, K. K. H.; Brennan, C.; Ma, Y.; Peng, S.; Eidelberg, D.; Tomishima, M.; Irion, S.; Stemple, W.; Abid, N.; Lampron, A.; Studer, L.; Henchcliffe, C.
作者单位：Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Cornell University; Weill Cornell Medicine; University of Toronto; Krembil Research Institute; University of Toronto; University of Toronto; University Health Network Toronto; Northwell Health; Northwell Health; Memorial Sloan Kettering Cancer Center; University of California System; University of California Irvine
摘要：Parkinson's disease is a progressive neurodegenerative condition with a considerable health and economic burden1. It is characterized by the loss of midbrain dopaminergic neurons and a diminished response to symptomatic medical or surgical therapy as the disease progresses2. Cell therapy aims to replenish lost dopaminergic neurons and their striatal projections by intrastriatal grafting. Here, we report the results of an open-label phase I clinical trial (NCT04802733) of an investigational cry...
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作者：Zhang, Junbing; Ali, Md Yousuf; Chong, Harrison Byron; Tien, Pei-Chieh; Woods, James; Noble, Carolina; Vornbaumen, Tristan; Ordulu, Zehra; Possemato, Anthony P.; Harry, Stefan; Fonticella, Jay Miguel; Fellah, Lina; Harrison, Drew; Ge, Maolin; Khandelwal, Neha; Huang, Yingfei; Chauvin, Maeva; Bischof, Anica Tamara; Hambelton, Grace Marie; Gohar, Magdy Farag; Zhang, Siwen; Choi, Mingyu; Bouberhan, Sara; Oliva, Esther; Mino-Kenudson, Mari; Pavlova, Natalya N.; Lawrence, Michael; Gainor, Justin F.; Beausoleil, Sean A.; Bardeesy, Nabeel; Mostoslavsky, Raul; Pepin, David; Ott, Christopher J.; Liau, Brian; Bar-Peled, Liron
作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Chinese Academy of Sciences; Shanghai Institute of Nutrition & Health, CAS; University of Chinese Academy of Sciences, CAS; Harvard University; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard Medical School; Cell Signaling Technology; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Massachusetts Institute of Technology (MIT); Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Utah System of Higher Education; University of Utah; Huntsman Cancer Institute; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
摘要：Reactive oxygen species (ROS) underlie human pathologies including cancer and neurodegeneration1,2. However, the proteins that sense ROS levels and regulate their production through their cysteine residues remain ill defined. Here, using systematic base-editing and computational screens, we identify cysteines in VPS35, a member of the retromer trafficking complex3, that phenocopy inhibition of mitochondrial translation when mutated. We find that VPS35 underlies a reactive metabolite-sensing pa...
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作者：Lipson, Mark; Ringbauer, Harald; Lucarini, Giulio; Aouadi, Nabiha; Aoudia, Louiza; Belhouchet, Lotfi; Cheronet, Olivia; Dahmani, Ariane-Rym; Genchi, Francesco; La Pastina, Francesco; Lucci, Michaela; de Lumley, Henry; Mansouri, Nabila; Nava, Alessia; Touj, Fatma; Mallick, Swapan; Rohland, Nadin; Coppa, Alfredo; Pinhasi, Ron; Reich, David
作者单位：Harvard University; Max Planck Society; Consiglio Nazionale delle Ricerche (CNR); Museum National d'Histoire Naturelle (MNHN); Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); University of Vienna; University of Vienna; Sapienza University Rome; Sapienza University Rome; University of Palermo; Sapienza University Rome; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard Medical School; Howard Hughes Medical Institute; Universita degli Studi di Roma Unitelma Sapienza
摘要：Ancient DNA from the Mediterranean region has revealed long-range connections and population transformations associated with the spread of food-producing economies1, 2, 3, 4, 5-6. However, in contrast to Europe, genetic data from this key transition in northern Africa are limited, and have only been available from the far western Maghreb (Morocco)1, 2-3. Here we present genome-wide data for nine individuals from the Later Stone Age through the Neolithic period from Algeria and Tunisia. The ear...
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作者：Rigual, Maria del Mar; Angulo-Aguado, Mariana; Zagorac, Sladjana; alvarez-Diaz, Ruth; Benitez-Mondejar, Marta; Yi, Fengming; Martinez-Garay, Carlos; Santos-de-Frutos, Karla; Kim, Eunjeong; Campos-Olivas, Ramon; Djouder, Nabil
作者单位：Kyungpook National University (KNU)
摘要：Liver regeneration after hepatectomy follows accurate coordination with the body's specific requirements1, 2-3. However, the molecular mechanisms, factors and particular hepatocyte population influencing its efficiency remain unclear. Here we report on a unique regeneration mechanism involving unconventional RPB5 prefoldin interactor 1 (URI1), which exclusively colocalizes with, binds to and activates glutamine synthase (GS) in pericentral hepatocytes. Genetic GS or URI1 depletion in mouse per...
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作者：Cheng, Xusen; Zhang, Lulu
作者单位：Renmin University of China
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作者：Sobel, Adam H.; Emanuel, Kerry A.
作者单位：Columbia University
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作者：Tollefson, Jeff
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作者：Tao, Kai-Shan; Yang, Zhao-Xu; Zhang, Xuan; Zhang, Hong-Tao; Yue, Shu-Qiang; Yang, Yan-Ling; Song, Wen-Jie; Wang, De-Sheng; Liu, Zheng-Cai; Li, Hai-Min; Chen, Yong; Ding, Rui; Sun, Shi-Ren; Yu, Ming; Li, Ji-Peng; Duan, Wei-Xun; Wang, Zhe; Wang, Jing-Wen; Liu, Jia-Yun; Zheng, Min-Wen; Zhang, Xi-Jing; Yin, Wen; Qin, Wei-Jun; Bian, Dong-Mei; Li, Lin; Li, Min; Lin, Zhi-Bin; Xu, Hao; Wei, Dan; Zhang, Hong; Duan, Juan-Li; Pan, Deng-Ke; Dong, Hai-Long; Wang, Lin; Dou, Ke-Feng
作者单位：Air Force Medical University; Air Force Medical University; Air Force Medical University; Air Force Medical University; Air Force Medical University; Air Force Medical University; Air Force Medical University; Air Force Medical University; Air Force Medical University; Air Force Medical University; Air Force Medical University; Air Force Medical University; Air Force Medical University; Air Force Medical University
摘要：The shortage of donors is a major challenge for transplantation; however, organs from genetically modified pigs can serve as ideal supplements1,2. Until now, porcine hearts and kidneys have been successively transplanted into humans3, 4, 5, 6-7. In this study, heterotopic auxiliary transplantation was used to donate a six-gene-edited pig liver to a brain-dead recipient. The graft function, haemodynamics, and immune and inflammatory responses of the recipient were monitored over the subsequent ...
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作者：Leonhardt, M.; Schweitzer, D.; Abbass, F.; Anjum, K. K.; Arndt, B.; Erlewein, S.; Endoh, S.; Geissler, P.; Imamura, T.; Jaeger, J. I.; Latacz, B. M.; Micke, P.; Voelksen, F.; Yildiz, H.; Blaum, K.; Devlin, J. A.; Matsuda, Y.; Ospelkaus, C.; Quint, W.; Soter, A.; Walz, J.; Yamazaki, Y.; Ulmer, S.; Smorra, C.
作者单位：Heinrich Heine University Dusseldorf; RIKEN; Johannes Gutenberg University of Mainz; Helmholtz Association; GSI Helmholtz-Center for Heavy Ion Research; Max Planck Society; European Organization for Nuclear Research (CERN); University of Tokyo; Leibniz University Hannover; Physikalisch-Technische Bundesanstalt (PTB); Imperial College London; Swiss Federal Institutes of Technology Domain; ETH Zurich; Friedrich Schiller University of Jena
摘要：Precision measurements using low-energy antiprotons, exclusively available at the antimatter factory (AMF) of CERN1, offer stringent tests of charge-parity-time (CPT) invariance, which is a fundamental symmetry in the Standard Model of particle physics2. These tests have been realized, for example, in antiprotonic helium3 and antihydrogen4. In our cryogenic Penning-trap experiments5, we measure the magnetic moments6,7 and charge-to-mass ratios of protons and antiprotons and now provide the mos...
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作者：Cheng, Ho Wan; Trifonov, Trifon; Lee, Man Hoi; Cantalloube, Faustine; Reffert, Sabine; Ramm, David; Quirrenbach, Andreas
作者单位：University of Hong Kong; Ruprecht Karls University Heidelberg; University of Sofia; University of Hong Kong; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Centre National de la Recherche Scientifique (CNRS); Institut de Planetologie et d'Astrophysique de Grenoble (IPAG); University of Canterbury
摘要：Close-in companion stars are expected to adversely influence the formation and orbital stability of circumstellar (S-type) planets by tidally truncating protoplanetary discs1, 2, 3-4, impeding mutual accretion of planetesimals5, 6, 7-8 and narrowing dynamically stable regions9. This explains the observed dearth of S-type planets in tight binary star systems10, 11, 12-13. nu Octantis, whose stellar components have a mean separation of 2.6 au, has long been suspected of hosting a circum-primary ...
