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作者:Dattaro, Laura
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作者:Gewin, Virginia
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作者:Johannessen, Cory M.; Johnson, Laura A.; Piccioni, Federica; Townes, Aisha; Frederick, Dennie T.; Donahue, Melanie K.; Narayan, Rajiv; Flaherty, Keith T.; Wargo, Jennifer A.; Root, David E.; Garraway, Levi A.
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作者:Wankmueller, Fabian J. P.; Delval, Louis; Lehmann, Peter; Baur, Martin J.; Cecere, Andrea; Wolf, Sebastian; Or, Dani; Javaux, Mathieu; Carminati, Andrea
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作者:Liu, Kehan; Zhang, Cheng
作者单位:University of Queensland
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作者:Jiang, Shengyu; Xu, Yuantao; Wang, Ruihong; Chen, Xinren; Guan, Chaoshuai; Peng, Yong; Liu, Fuzhu; Wang, Mingxu; Liu, Xu; Zhang, Shaoyou; Tian, Genqi; Jin, Shenbao; Wang, Huiyuan; Toda, Hiroyuki; Jin, Xuejun; Liu, Gang; Gault, Baptiste; Sun, Jun
作者单位:Xi'an Jiaotong University; Shanghai Jiao Tong University; Xi'an University of Technology; Lanzhou University; Shandong University; Hebei University of Technology; Kyushu University; Imperial College London
摘要:Hydrogen embrittlement (HE) impairs the durability of aluminium (Al) alloys and hinders their use in a hydrogen economy(1, 2-3). Intermetallic compound particles in Al alloys can trap hydrogen and mitigate HE4, but these particles usually form in a low number density compared with conventional strengthening nanoprecipitates. Here we report a size-sieved complex precipitation in Sc-added Al-Mg alloys to achieve a high-density dispersion of both fine Al3Sc nanoprecipitates and in situ formed cor...
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作者:Ryan, Feargal J.; Clarke, Michelle; Lynn, Miriam A.; Benson, Saoirse C.; McAlister, Sonia; Giles, Lynne C.; Choo, Jocelyn M.; Rossouw, Charne; Ng, Yan Yung; Semchenko, Evgeny A.; Richard, Alyson; Leong, Lex E. X.; Taylor, Steven L.; Blake, Stephen J.; Mugabushaka, Joyce I.; Walker, Mary; Wesselingh, Steve L.; Licciardi, Paul V.; Seib, Kate L.; Tumes, Damon J.; Richmond, Peter; Rogers, Geraint B.; Marshall, Helen S.; Lynn, David J.
作者单位:South Australian Health & Medical Research Institute (SAHMRI); Flinders University South Australia; University of Adelaide; Robinson Research Institute; University of Adelaide; Wesfarmers Limited; University of Western Australia; University of Adelaide; Murdoch Children's Research Institute; Griffith University; Griffith University - Gold Coast Campus; University of Melbourne; Centre for Cancer Biology; SA Pathology; University of South Australia; Perth Childrens Hospital
摘要:Accumulating evidence indicates that antibiotic exposure may lead to impaired vaccine responses1, 2, 3-4; however, the mechanisms underlying this association remain poorly understood. Here we prospectively followed 191 healthy, vaginally born, term infants from birth to 15 months, using a systems vaccinology approach to assess the effects of antibiotic exposure on immune responses to vaccination. Exposure to direct neonatal but not intrapartum antibiotics was associated with significantly lowe...
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作者:Ha, Yoo-Jin Jiny; Nisal, Ashna; Tang, Isaac; Lee, Chanjae; Jhamb, Ishani; Wallace, Cassidy; Howarth, Robyn; Schroeder, Sarah; Vong, Keng loi; Meave, Naomi; Jiwani, Fiza; Barrows, Chelsea; Lee, Sangmoon; Jiang, Nan; Patel, Arzoo; Bagga, Krisha; Banka, Niyati; Friedman, Liana; Blanco, Francisco A.; Yu, Seyoung; Rhee, Soeun; Jeong, Hui Su; Plutzer, Isaac; Major, Michael B.; Benoit, Beatrice; Pous, Christian; Heffner, Caleb; Kibar, Zoha; Bot, Gyang Markus; Northrup, Hope; Au, Kit Sing; Strain, Madison; Ashley-Koch, Allison E.; Finnell, Richard H.; Le, Joan T.; Meltzer, Hal S.; Araujo, Camila; Machado, Helio R.; Stevenson, Roger E.; Yurrita, Anna; Mumtaz, Sara; Ahmed, Awais; Khara, Mulazim Hussain; Mutchinick, Osvaldo M.; Medina-Bereciartu, Jose Ramon; Hildebrandt, Friedhelm; Melikishvili, Gia; Marwan, Ahmed I.; Capra, Valeria; Noureldeen, Mahmoud M.; Salem, Aida M. S.; Issa, Mahmoud Y.; Zaki, Maha S.; Xu, Libin; Lee, Ji Eun; Shin, Donghyuk; Alkelai, Anna; Shuldiner, Alan R.; Kingsmore, Stephen F.; Murray, Stephen A.; Gee, Heon Yung; Miller, W. Todd; Tolias, Kimberley F.; Wallingford, John B.; Kim, Sangwoo; Gleeson, Joseph G.; Spina Bifida Sequencing Consortium, Joan T.; Koch, Allison E. Ashley; Lupo, Philip J.; Magana, Tony; Kolvenbach, Caroline M.; Shril, Shirlee; Takahashi, Yukitoshi; Salimi-Dafsari, Hormos; Phillips, H. Westley; Hanak, Brian; Kara, Bulent; Gunes, Ayfer Sakarya; Gonda, David D.; Kirmani, Salman; Tkemaladze, Tinatin
作者单位:University of California System; University of California San Diego; Yonsei University; Yonsei University Health System; Yonsei University; Yonsei University Health System; University of Texas System; University of Texas Austin; Baylor College of Medicine; Yonsei University; Yonsei University Health System; Yonsei University; Sungkyunkwan University (SKKU); Washington University (WUSTL); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Saclay; Universite Paris Saclay; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Saint-Louis - APHP; Hopital Universitaire Antoine-Beclere - APHP; Jackson Laboratory; Universite de Montreal; University of Texas System; University of Texas Health Science Center Houston; Duke University; Baylor College of Medicine; Baylor College of Medicine; Rady Childrens Hospital San Diego; Universidade de Sao Paulo; Greenwood Genetic Center; Universidad de Concepcion; Pakistan Institute of Medical Sciences; Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran - Mexico; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; University of Missouri System; University of Missouri Columbia; University of Genoa; IRCCS Istituto Giannina Gaslini; Egyptian Knowledge Bank (EKB); Beni Suef University; Egyptian Knowledge Bank (EKB); National Research Centre (NRC); University of Washington; University of Washington Seattle; Regeneron; State University of New York (SUNY) System; Stony Brook University; Pohang University of Science & Technology (POSTECH); Baylor College of Medicine; Mekelle University; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Boston Children's Hospital; University of Cologne; Stanford University; Childrens Hospital of Orange County; Kocaeli University; Aga Khan University; Tbilisi State Medical University
摘要:Meningomyelocele (also known as spina bifida) is considered to be a genetically complex disease resulting from a failure of the neural tube to close. Individuals with meningomyelocele display neuromotor disability and frequent hydrocephalus, requiring ventricular shunting. A few genes have been proposed to contribute to disease susceptibility, but beyond that it remains unexplained1. We postulated that de novo mutations under purifying selection contribute to the risk of developing meningomyel...
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作者:Kwon, Diana
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作者:Grant, Luke; Vanderkelen, Inne; Gudmundsson, Lukas; Fischer, Erich; Seneviratne, Sonia I.; Thiery, Wim
作者单位:Vrije Universiteit Brussel; Environment & Climate Change Canada; Canadian Centre for Climate Modelling & Analysis (CCCma); KU Leuven; Royal Meteorological Institute of Belgium; Swiss Federal Institutes of Technology Domain; ETH Zurich
摘要:Climate extremes are escalating under anthropogenic climate change1. Yet, how this translates into unprecedented cumulative extreme event exposure in a person's lifetime remains unclear. Here we use climate models, impact models and demographic data to project the number of people experiencing cumulative lifetime exposure to climate extremes above the 99.99th percentile of exposure expected in a pre-industrial climate. We project that the birth cohort fraction facing this unprecedented lifetim...