12期

最新文章

• Young children understand how social connections affect what people know about each other AI翻译
  作者：Chuey, Aaron; Jara-Ettinger, Julian; Gweon, Hyowon
  作者单位：Stanford University; Harvard University; Yale University
  摘要：An unwritten expectation in our everyday social interactions is that intimate personal information about someone-insider knowledge-is usually confined within close relationships. For example, it would be odd, or even unsettling, if a stranger knew about your favorite movie. Such expectations about who knows what about whom constitute a cornerstone of complex social behavior, but much remains unknown about their cognitive underpinnings and developmental origins. Drawing on parental report (Stud...
• The cross-linking activity of transglutaminase 2 drives α- Synuclein pathology in synucleinopathy models AI翻译
  作者：Hassanzadeh, Kambiz; Liu, Jun; Zhang, Jie; Tabari, Mohadeseh Abouhosseini; Maddila, Santhosh; Mouradian, M. Maral
  作者单位：Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences; Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences
  摘要：Transglutaminase 2 (TG2) is implicated in synucleinopathies including Parkinson's gation in vitro, and evidence for its activity is detected in Lewy bodies in human postmortem brains. Additionally, TG2 overexpression exacerbates alpha- Syn toxicity in double transgenic mice, while TG2 deletion mitigates the phenotype of alpha- Syn transgenic mice. Considering that TG2 is a multidomain and multifunctional protein, the present study was carried out to confirm that the transamidase activity of TG...
• Elucidation of a potent pro-resolving mediator of inflammation resolution via human neutrophil-vascular endothelial cell interactions AI翻译
  作者：Nshimiyimana, Robert; Chiang, Nan; Serhan, Charles N.
  作者单位：Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School
  摘要：The acute inflammatory response is a highly coordinated programmed sequence that enables neutrophils to transmigrate from venules into tissues. Ideally self-limited, the active resolution phase produces specialized molecules that stimulate resolution and prevent collateral tissue damage from excessive neutrophil infiltration. The superfamily of pro-resolving molecules is termed specialized pro-resolving mediators including the essential polyunsaturated fatty acid-derived lipoxins, resolvins, p...
• N- glucosylation of indole-3-acetyl amino acids modulates auxin metabolism and growth traits in Oryza sativa AI翻译
  作者：Zenji, Anna; Hata, Kimihiko; Segami, Shoji; Makita, Nobue; Kojima, Mikiko; Yoshino, Mika; Yoshino-Kida, Mika; Nagai, Keisuke; Ashikari, Motoyuki; Matsubara, Kazuki; Yano, Masahiro; Fukuoka, Shuichi; Hayashi, Ken-Ichiro; Sato, Yutaka; Hobo, Tokunori; Inukai, Yoshiaki; Sakakibara, Hitoshi
  作者单位：Nagoya University; National Institutes of Natural Sciences (NINS) - Japan; National Institute for Basic Biology (NIBB); Graduate University for Advanced Studies - Japan; RIKEN; Nagoya University; National Institute of Agrobiological Sciences - Japan; National Agriculture & Food Research Organization - Japan; Okayama University of Science; Research Organization of Information & Systems (ROIS); National Institute of Genetics (NIG) - Japan; Graduate University for Advanced Studies - Japan; Nagoya University
  摘要：Dynamic regulation of auxin (indole-3-acetic acid; IAA) levels is crucial for proper plant growth and development and is finely regulated through biosynthesis, transport, metabolic inactivation, and signal transduction. While O-glucosylation of IAA is well established, the physiological significance of N-glucosylation pathways acting on IAA-amino acid conjugates remains largely unexplored. Here, we identify a UDP-glucosyltransferase in rice (Oryza sativa), designated IAAspGT, that catalyzes th...
• Underwater cultural heritage and extreme events: Storm impacts under climate change AI翻译
  作者：Germinario, Luigi; Mclelland, Stuart J.; Mazzoli, Claudio
  作者单位：University of Padua; University of Hull
  摘要：Extreme weather events cause severe ecological disruptions to the marine environment and socioeconomic impacts, while also endangering the evidences of human history resting underwater. Storms, in particular, generate high-intensity currents that lead to substantial material loss and textural alteration. We present a quantitative risk assessment of underwater cultural heritage exposed to storm events, considering climate change and the vulnerability of historical stone materials. We monitored ...
• Liquid anomalies and fragility of supercooled antimony AI翻译
  作者：Giuliani, Flavio; Mattioli, Francesco Guidarelli; Chen, Yuhan; Baratella, Dario; Dragoni, Daniele; Bernasconi, Marco; Russo, John; Boeri, Lilia; Mazzarello, Riccardo
  作者单位：Sapienza University Rome; University of Milano-Bicocca
  摘要：Phase-change materials (PCMs) based on group IV, V, and VI elements, such as Ge, Sb, and Te, exhibit distinctive liquid-state features, including thermodynamic anomalies and unusual dynamical properties, which are believed to play a key role in their fast and reversible crystallization behavior. Antimony (Sb), a monoatomic PCM with ultrafast switching capabilities, stands out as the only elemental member of this group for which the properties of the liquid and supercooled states have so far re...
• Species- specific roles of SP1 in bovine and human embryonic genome activation and early embryonic development AI翻译
  作者：Jin, Hao; Xiao, Lieying; He, Xiaolin; Hu, Bingjie; Shi, Yan; Xu, Bo; Tong, Xiaomei; Wang, Shaohua; Zhao, Panpan; Luo, Lei; Zhang, Kun
  作者单位：Zhejiang University; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Zhejiang University; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California Los Angeles Medical Center; Michigan State University; Fudan University
  摘要：Embryonic genome activation (EGA) marks the onset of the embryonic program and enables the transition toward the first lineage specification. However, the molecular features of EGA and the transcription factors (TFs) orchestrating this process remain unclear. Here, by performing single- cell RNA- seq on bovine embryos, we reveal that major EGA is asynchronously initiated among blastomeres at the 8- cell stage. Integrative analyses reveal distinct protein accumulation compared with transcriptio...
• Synthetic lethality between RB- loss and E2F3 inhibition in small cell cancers targeted by pyrimidine synthesis blockade AI翻译
  作者：Abt, Evan R.; Wang, Liang; Varuzhanyan, Grigor; Freeland, Jack; He, Tian; Pena-Garcia, Guadalupe M.; Ruegg, Lauryn; Mclaughlin, Jami; Cheng, Donghui; Balanis, Nikolas G.; Chen, Chia- Chun; Xu, Yang; Xing, Yi; Memarzadeh, Sanaz; Radu, Caius G.; Graeber, Thomas G.; Witte, Owen N.
  作者单位：University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California System; UCLA Jonsson Comprehensive Cancer Center; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; Thomas Jefferson University; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Pennsylvania Medicine; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California Los Angeles Medical Center; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles
  摘要：Small cell carcinoma is a highly lethal cancer variant often found with neuroendocrine (NE) features, as exemplified by small cell lung cancer and small cell NE prostate cancer (SCPC). A genome- wide CRISPR dependency screen using SCPC models generated through human prostate cell transformation identifies a requirement for the transcription factor E2F3. E2F3 dependency is linked to RB inactivation, a near universal occurrence across small cell cancers. The requirement for E2F3 is shared by RB-...
• Photoreceptor control of Platynereis growth and lifespan via evolutionarily conserved molecular pathways AI翻译
  作者：Andreatta, Gabriele; Scaramuzza, Federico; Coric, Aida; Orel, Lukas; Mat, Audrey M.; Takekata, Hiroki; Poehn, Birgit; Milivojev, Nadja; Tessmar-Raible, Kristin
  作者单位：University of Vienna; University of Vienna; Medical University of Vienna; University of the Ryukyus; Carl von Ossietzky Universitat Oldenburg
  摘要：Natural light is severely affected by human impact on Earth, yet little is known about the roles light receptors have outside vision and rhythmic processes, despite their tremendously wide abundance. Here we show that loss-of-function of the light-receptive cryptochrome (l-cry) in marine bristleworms significantly increases lifespan and adult size, similarly to wild-types reared in constant darkness. Quantitative transcriptomics revealed hormonal players crucial for invertebrate and vertebrate...
• Myeloarchitecture, intra-and interhemispheric and thalamocortical connections of area 3b representing the teeth and tongue in galagos AI翻译
  作者：Qi, Hui- Xin; O'brien, Barbara M. J.; Reed, Jamie L.; Kaas, Jon H.
  作者单位：Vanderbilt University
  摘要：The representations of the face and oral cavity occupy a large but understudied portion of primary somatosensory cortex (S1 or area 3b) in primates. These studies are clearly important in processing food, taste, and vocalizations. Little is known about the neuronal representations of the teeth and tongue, their relationship with myeloarchitecture, and their cortical and thalamic connections in area 3b of strepsirrhine galagos. In owl and squirrel monkeys, and likely in macaque monkeys, the mos...