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作者：Lombardo, Evan R.; Pijewski, Robert S.; Lustig, Jake T.; Dhari, Zaenab; Lahiri, Anirudhya; Papile, Lucille E.; Lavoie, Erica R.; Scanlon, Vanessa M.; Bartley, Jenna M.; Crocker, Stephen J.
作者单位：University of Connecticut; Quinnipiac University; University of Connecticut; University of Connecticut; University of Connecticut
摘要：Aging is a primary risk factor for disease progression in multiple sclerosis (MS). Because of this, treatments that can reduce the consequences of molecular aging, like senescence, have been proposed as a strategy to address disease progression. However, the effects of senolytics, a class of drugs which selectively ablate senescent cells, on the central nervous system are largely unknown. Here, we examined the effects of senolytic treatment on myelination and oligodendrocyte function in vivo u...
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作者：Moon, Seulgi; Formetta, Giuseppe; Higa, Justin T.; Busti, Riccardo; Bellugi, Dino G.; Milledge, David G.; Ebel, Brian A.; Dietrich, William E.
作者单位：University of California System; University of California Los Angeles; University of Trento; University of California System; University of California Berkeley; Newcastle University - UK; United States Department of the Interior; United States Geological Survey; University of California System; University of California Berkeley
摘要：The deep critical zone (CZ) has long been recognized for its importance in influencing shallow landslides but was not considered feasible to include in slope stability models at the watershed scale. Here, we demonstrate that simple approximations of the CZ in a fully coupled hydrologic and soil slope stability model can effectively capture the location, timing, and likely size of shallow landslides. To achieve this, we use coupled, process-based models that incorporate the effects of 1) deep C...
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作者：Palmer, Tim
作者单位：University of Oxford
摘要：Motivated in part by John Wheeler's assertion that the continuum nature of Hilbert Space conceals the it-from-bit information-theoretic character of the quantum wavefunction, a theory of quantum physics (Rational Quantum Mechanics-RaQM) is proposed based on a specific discretization of complex Hilbert Space. The Schr & ouml;dinger equation is not modified in RaQM, even during measurement. However, the bases in which the quantum state is defined must satisfy certain rational-number constraints....
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作者：Wang, Yu; Zhang, Qingyang; Wu, Shuangshuang; Hu, Keyu; Bu, Siyi; Song, Yingjie; Fei, Fan; Cheng, Heming; Wu, Di; Wang, Shuang; Guo, Yi; Xu, Cenglin; Li, Wenlu; Li, Lihong; Wu, Jiannong; Wang, Yi; Chen, Zhong
作者单位：Zhejiang Chinese Medical University; Zhejiang University; Zhejiang Chinese Medical University; Zhejiang University
摘要：Vagus nerve stimulation offers a promising strategy for seizure control but remains limited by its invasive delivery. Here, we reveal electroacupuncture (EA), an ancient neuromodulatory technique rooted in traditional Chinese medicine, at specific somatic acupoints linked to the vagal-brain axis to treat epilepsy and delineate the precise underlying neural mechanisms. We demonstrate that EA at the Dazhui (GV14) acupoint exhibits broad-spectrum antiseizure efficacy across multiple seizure model...
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作者：Zhu, Yuting; Anderson, Hanna S.; Salcedo, Eli; Miller, Samuel E.; Longnecker, Krista; Soule, Melissa C. Kido; Haley, Sheean T.; Swarr, Gretchen J.; Braakman, Rogier; Dyhrman, Sonya T.; Kujawinski, Elizabeth B.
作者单位：Woods Hole Oceanographic Institution; Columbia University; Columbia University; Massachusetts Institute of Technology (MIT); Marine Biological Laboratory - Woods Hole; Massachusetts Institute of Technology (MIT); Old Dominion University
摘要：The marine labile dissolved organic carbon (DOC) pool is a dynamic reservoir of thousands of molecules that cycles approximately one-quarter of Earth's primary production within days to weeks. After excretion by phytoplankton and other microbes, metabolites are rapidly consumed, resulting in low standing concentrations (picomolar to low nanomolar). Despite the decades-long search for labile DOC sources and molecular identities, marine phytoplankton exometabolomes are not well characterized, la...
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作者：Addington, Emily; Wale, Kabo R.; Horsburgh, Emily; Fargeas, Margot; Spathis, Leonidas; Lesniak, Weronika; Flavin, Saoirse; Rimbi, Patricia T.; Mark, David R.; Sandalli, Sofia; Serrano, Ester; Blackburn, Gavin; Regnault, Clement; Whitfield, Phillip D.; Connolly, James P. R.; Roe, Andrew J.; O'boyle, Nicky
作者单位：University of Glasgow; University of Botswana; Trinity College Dublin; University of Glasgow; Newcastle University - UK
摘要：Attaching and effacing pathogens, including enterohemorrhagic Escherichia coli (EHEC), colonize their preferred intestinal niche by sensing diverse host-, diet-, and microbiota-derived signals and coordinating the expression of virulence factors. D-serine, a host metabolite abundant in urine but scarce in the intestine, restricts EHEC colonization by transcriptionally repressing the type 3 secretion system (T3SS) while activating the SOS stress response. However, the mechanism underlying virul...
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作者：Brahmachari, Sumitabha; Oliveira, Antonio B.; Mello, Matheus F.; Contessoto, Vinicius G.; Onuchic, Jose N.
作者单位：Rice University; Rice University; Rice University; Rice University; Rice University
摘要：Faithful chromosome segregation during bacterial replication requires global reorganization of the nucleoid, where Structural Maintenance of Chromosomes (SMC) complexes play a crucial role. Here, we develop an energy landscape framework that integrates data-driven pairwise interactions with coarse-grained polymer physics to infer the 3D architectural ensembles of Escherichia coli and Bacillus subtilis chromosomes throughout replication. We show that SMC-mediated long-range lengthwise compactio...
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作者：Rossi, Matthew W.; Tucker, Gregory E.; Anderson, Suzanne P.; Anderson, Robert S.; Mcglinchy, Joseph
作者单位：University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder
摘要：The transition from soil-mantled to bedrock-dominated landscapes is important to hydrology, ecology, and landscape evolution. Where classical theory predicts that this transition abruptly occurs once erosion rates exceed soil production ones, actual landscapes show a much more gradual transition. The Rampart Range, CO, is an unglaciated, forested mountain range with uniform lithology that spans this transition, providing an opportunity to interrogate how topography, soil cover, and forest stru...
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作者：Wen, Michael T. C.; Prince, Victoria E.; Gillis, J. Andrew
作者单位：University of Chicago; Marine Biological Laboratory - Woods Hole; University of Chicago
摘要：The origin of paired fins is an unresolved controversy in vertebrate evolutionary biology. Karl Gegenbaur famously proposed that paired fins evolved by the transformation of a gill arch, but this hypothesis remains largely unsupported by the fossil record. Also, seemingly at odds with gill arch-paired fin serial homology are their distinct embryonic origins from neural crest and lateral plate mesoderm, respectively. We have previously shown that skate gill arch skeletal elements may derive sol...
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作者：Chen, Junchen; Xu, Ming; Liu, Yuan; Hadi, Fatemeh; Xue, Shuanghong; Chien, Shu; Zhong, Sheng
