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作者：Fu, Chunmei; Ma, Tianle; Clausen, Bjorn E.; Mellman, Ira; Jiang, Aimin
作者单位：Henry Ford Health System; Henry Ford Hospital; Henry Ford Cancer Institute; Henry Ford Health System; Michigan State University; Michigan State University College of Human Medicine; Oakland University; Johannes Gutenberg University of Mainz; Johannes Gutenberg University of Mainz; University of California System; University of California San Francisco
摘要：Conventional type 1 dendritic cells (cDC1s) are specialized for cross-presenting tumor antigens and determining the efficacy of immunotherapies, including immune checkpoint blockade and adoptive cell therapy. However, their rarity and tumor-induced dysfunction severely limit CD8 T cell priming and represent a central bottleneck to therapeutic efficacy. While strategies such as anti-DEC-205-mediated antigen delivery and Flt3L-driven DC expansion can enhance host DC function, their reliance on f...
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作者：Kuo, Po-Lin; Chen, Guan-Yu; Fan, Yu-Chia; Wan, Wing-Ying; Yang, Patricia J.
作者单位：National Tsing Hua University
摘要：Dust bathing is a widespread behavior among birds that helps remove ectoparasites, but its mechanical basis remains poorly understood. Here we show that wing flapping during dust bathing generates sand-particle collisions sufficient to dislodge feather mites. Using high-speed video analysis across 34 bird species, we found that wing-flapping frequency scales inversely with body mass ( f similar to M-0.20), ranging from 1 to 10 Hz. Since feather motion matches wing motion, we use mechanical sha...
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作者：Chen, Keyu; Deng, Yu; Hu, Tianming; Li, Jichun; Huang, Xin-Yu; Zhu, Chengcheng; Chen, Honggang; Chen, Meihua; Wu, Limin; Deng, Yonghui; Xie, Wenhe
作者单位：Fudan University; Fudan University; Donghua University; Inner Mongolia University
摘要：Periodic porous structures with interconnected pore channels and high specific surface area are widely spread in natural world. These structures guarantee rapid mass transportation and efficient biochemical reactions within organisms, thereby satisfying the requirements of complex life activities. Inspired by the periodic porous membrane and breathing process of the mammalian respiratory system, a steady nonequilibrium chemical sensing process is established to achieve high-accuracy gas discri...
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作者：Hiebert, Laurel S.; Yi, Soojin, V
作者单位：University of Vienna; University of California System; University of California Santa Barbara; University of California System; University of California Santa Barbara; University of California System; University of California Santa Barbara
摘要：The extent of DNA methylation varies widely across animal genomes, from almost undetectable levels in some taxa to high, pervasive methylation in others. Although DNA methylation has been linked to gene regulation, genome defense, and cellular memory, the evolutionary forces shaping its diversity across taxa remain unresolved. Using phylogenetic comparative analysis of 175 invertebrate species spanning 14 phyla, we show that species with greater regenerative capacity exhibit higher genome-wide...
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作者：Zhong, Xiaoling; Zou, Yuhua; Zhang, Chun - Li
作者单位：University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center
摘要：The stem cell factor SOX2 can reprogram resident glial cells into neurons in the adult mammalian central nervous system, but the molecular mechanisms underlying this process remain poorly understood. Here, we show that both SOX2 phosphorylation and the PRKDC-dependent nonhomologous end joining (NHEJ) pathway are essential for SOX2-mediated in vivo glia-to-neuron reprogramming. A phospho-mimetic SOX2 mutant significantly enhances reprogramming output without altering neuronal fate. Conversely, ...
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作者：Pearlman, Alexander H.; Mog, Brian J.; Hwang, Michael S.; Rincon-Torroella, Jordina; Dinapoli, Sarah R.; Paul, Suman; Douglass, Jacqueline; Hsiue, Emily Han-Chung; Glavaris, Stephanie A.; Pardoll, Drew M.; Papadopoulos, Nickolas; Kinzler, Kenneth W.; Bettegowda, Chetan; Zhou, Shibin; Vogelstein, Bert; Konig, Maximilian F.
作者单位：Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Howard Hughes Medical Institute; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins University; Johns Hopkins Medicine
摘要：Lethal toxins could become potent therapies against cancer, but their clinical utility is limited by adverse events upon systemic administration. These could be reduced if the toxins were delivered by effector cells that specifically infiltrate cancers, thereby releasing toxins locally into the tumor microenvironment. One of the challenges underlying this strategy is that cells delivering toxins would have to be resistant to them. We address this obstacle by showing that effectors derived from...
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作者：Williamson, Valerie M.; Siddique, Shahid
作者单位：University of California System; University of California Davis; University of California System; University of California Davis
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作者：Huang, Yinan; Gleich, David F.; Li, Pan
作者单位：University System of Georgia; Georgia Institute of Technology; Purdue University System; Purdue University
摘要：Magnetic graphs, originally developed to model quantum systems under magnetic fields, have recently emerged as a powerful framework for analyzing complex directed networks. Existing research has primarily used the spectral properties of the magnetic graph matrix to study global and stationary network features. However, their capacity to model local, nonequilibrium behaviors, often described by matrix powers, remains largely unexplored. We present a combinatorial interpretation of the magnetic ...
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作者：Jaffe, Yitzchak; Womack, Andrew; Tache, Karine; Kletzerman, Mitya; Marom, Nimrod; Palzur, Ron; Sun, Bo; Zhao, Yichao
作者单位：University of Haifa; University of Haifa; Laval University; Universidade do Algarve
摘要：This paper demonstrates the importance of applying multiple analytical methods in ceramic analysis for understanding colonial contact in the past. We examine the Shang-Zhou transition (circa 1000 BCE) by investigating community-specific uses of li tripod cooking vessels at multiple sites in Shandong Province. Craft traditions and food practices serve as valuable proxies for understanding past social identities and offer new perspectives on culture contact, migration, and colonialism. Moving aw...
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作者：Li, Qihao; Shi, Zixiao; Bundschu, Colin R.; Pollock, Christopher J.; Villarino, Andres Molina; Krumov, Mihail R.; Zeng, Rui; Muller, David A.; Abruna, Hector D.
作者单位：Cornell University; Cornell University; Cornell University; Cornell University
摘要：The development of nonprecious-metal-based hydrogen oxidation reaction (HOR) electrocatalysts remains as the bottleneck for achieving high-performance, platinum group metal-free (PGM-free) alkaline/anion exchange membrane fuel cells. Numerous efforts have been dedicated toward enhancing the HOR activity of Ni catalysts due to the lack of alternative choices. However, mechanistic insights relating to electrocatalytic activity and degradation remain a matter of debate, and proposed models tend t...
