12期

最新文章

• Partner preferences for resources adapt to income and gender economic inequality AI翻译
  作者：Murphy, Macken; Harmon-Jones, Sylvia K.; Harrington, Auguste G.; Brooks, Robert C.; Blake, Khandis R.
  作者单位：University of Melbourne; University of Wollongong; New York University; New York University Abu Dhabi; University of New South Wales Sydney
  摘要：For over three decades, scholars have contested whether sex differences in ideal partner preferences for age, resources, and physical attractiveness result chiefly from evolution or cultural gender inequality. Here, we test a perspective compatible with each of these competing views: partner preferences for resources adapt strategically, such that they become stronger for the sex that is poorer and individuals who are poorer, as such preferences are more useful to these individuals. Our prereg...
• Origin of eukaryotic plasmalogen biosynthesis by horizontal gene transfer from myxobacteria AI翻译
  作者：Trinidad-Barnech, Juan Manuel; Navalon, Irene del Rey; Mitsi, Konstantina; Monera-Girona, Antonio J.; Najle, Sebastian R.; Padmanabhan, S.; Ruiz-Trillo, Inaki; Elias-Arnanz, Montserrat
  作者单位：Universidad de la Republica, Uruguay; Instituto de Investigaciones Biologicas Clemente Estable Uruguay; University of Murcia; Consejo Superior de Investigaciones Cientificas (CSIC); Consejo Superior de Investigaciones Cientificas (CSIC); Pompeu Fabra University; CSIC-UPF - Institut de Biologia Evolutiva (IBE); Spanish Institute of Oceanography; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Quimica Fisica Blas Cabrera (IQF-CSIC); ICREA; Universitat Internacional de Catalunya (UIC)
  摘要：Plasmalogens are a unique class of glycerophospholipids defined by a distinctive vinyl ether bond. While these lipids are abundant in animals and important for human health, their evolutionary history remains enigmatic, mostly due to their absence in some major eukaryotic lineages like plants. Here, we resolve the origin and evolution of the aerobic plasmalogen biosynthesis pathway in eukaryotes. Through comprehensive phylogenomic analysis and experimental validation of enzyme activity and pla...
• Sleep alters neurovascular and hydrodynamic coupling in the human brain AI翻译
  作者：Vayrynena, Tommi; Tuunanen, Johanna; Helakari, Heta; Elabasy, Ahmed; Korhonen, Vesa; Huotari, Niko; Piispala, Johanna; Kallio, Mika; Nedergaard, Maiken; Kiviniemi, Vesa
  作者单位：University of Oulu; University of Oulu; University of Oulu; University of Rochester; University of Copenhagen; University of Oulu
  摘要：Sleep is essential for maintaining brain tissue homeostasis, which is facilitated by enhanced cerebrospinal fluid (CSF) solute transport. Infraslow (<0.1 Hz) vasomotion, CSF flow, and electrophysiological potential all increase during sleep, but their contributions as potential drivers of CSF flow in human brain remain unknown. To investigate this, we measured these signals in healthy volunteers across sleep-wake states using functional MRI blood oxygen level-dependent (BOLD), electroencephalo...
• Phosphorus enrichment does not enlarge the predicted CO2 fertilization effect on forest carbon sequestration AI翻译
  作者：Wang, Bin; Lyu, He; Zhang, Xueqian; Jiang, Mingka; Medlyn, Belinda E.; Warlind, David; Knauer, Jurgen; Fleischer, Katrin; Goll, Daniel S.; Olin, Stefan; Yang, Xiaojuan; Yu, Li; Zaehle, Sonke; Zhang, Haicheng; Schufft, Kristian; Crous, Kristine Y.; Carrillo, Yolima; Macdonald, Catriona A.; Anderson, Ian C.; Boer, Matthias M.; Farrell, Mark; Gherlenda, Andrew; Castaneda-Gomez, Laura; Hasegawa, Shun; Jarosch, Klaus; Milham, Paul; Ochoa-Ochoa, Raul; Pathare, Varsha; Pihlblad, Johanna; Pineiro, Juan; Power, Sally A.; Reich, Peter B.; Riegler, Markus; Ellsworth, David S.; Smith, Benjamin
  作者单位：Zhejiang University; Western Sydney University; Lund University; Commonwealth Scientific & Industrial Research Organisation (CSIRO); University of Technology Sydney; Max Planck Society; Vrije Universiteit Amsterdam; Centre National de la Recherche Scientifique (CNRS); CEA; Universite Paris Saclay; United States Department of Energy (DOE); Oak Ridge National Laboratory; University of Hamburg; Sun Yat Sen University; Max Planck Society; Technical University of Munich; Commonwealth Scientific & Industrial Research Organisation (CSIRO); CSIRO Agriculture & Food; Norwegian Institute of Bioeconomy Research; Swiss Federal Research Station Agroscope; University of Bern; University of Bern; Universidad de Cadiz; Royal Netherlands Academy of Arts & Sciences; Netherlands Institute of Ecology (NIOO-KNAW); Cornell University; University of Birmingham; University of Birmingham; Universidad Politecnica de Madrid; University of Minnesota System; University of Minnesota Twin Cities; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan
  摘要：The capacity of nutrient-limited forests to enhance carbon (C) sequestration under elevated CO2 (eCO2) remains a critical uncertainty in C cycle modeling. While existing evidence suggests that low phosphorus (P) bioavailability may constrain CO2 fertilization effects on plant growth, the extent to which this limitation modulates ecosystem responses to eCO2 in forests adapted to P-deficient soils remains poorly understood. Here, using eight P-enabled models, we simulated the magnitudes and mech...
• Dual-encoder contrastive learning accelerates enzyme discovery AI翻译
  作者：Rocks, Jason W.; Truong, Dat P.; Rappoport, Dmitrij; Mander, Samuel Maddrell; Alarcon, Daniel A. Martin; Lee, Toni M.; Crossan, Steven; Goldford, Joshua E.
  摘要：The ability to engineer enzymes for desired reactions is a cornerstone of modern biotechnology, yet identifying suitable starting proteins remains a critical bottleneck. Although contrastive learning offers a compelling computational approach for enzyme discovery, these models have yet to be implemented at scale or proven effective in real-world experimental settings. Here, we present Horizyn-1, a computationally efficient deep learning framework that enables large-scale reaction-to-enzyme rec...
• Gustatory sensing by ovipositor drives maternal avoidance of hesperidin to benefit the offspring in a major agricultural fly pest AI翻译
  作者：Dong, Bao; Peng, Yuanyuan; Kou, Ruohan; Li, Hongfei; Cao, Fu; Lan, Xinyu; Wang, Jinjun; Jiang, Hongbo
  作者单位：Southwest University - China; Southwest University - China
  摘要：Females of the oriental fruit fly (Bactrocera dorsalis) disproportionately oviposit in unripe fruits, despite their lower nutritional value compared to ripe fruits, but the sensory cues driving such counterintuitive site selection have not been determined. Here, using an oriental fruit fly-mango interaction system, we identified a specific flavonoid compound, hesperidin, as a major avoidance cue driving oviposition site selection in this species. Hesperidin accumulates as mango fruits ripen, a...
• SUN5 forms a regular protein lattice reinforcing the sperm head-tail junction AI翻译
  作者：Moecking, Jonas; Doroshev, Svetlana; Leung, Miguel Ricardo; Zeev-Ben-Mordehai, Tzviya
  作者单位：Utrecht University; Royal Netherlands Academy of Arts & Sciences; Hubrecht Institute (KNAW); Utrecht University; Utrecht University Medical Center
  摘要：Spermatozoa strongly rely on their streamlined morphology to successfully ferti lize an oocyte. A striking example of a morphological defect resulting in infertility is acephalic spermatozoa syndrome, a rare but severe condition leading to detach ment of the sperm head and tail. Among the most common genetic causes for this syndrome are mutations in the linker of nucleo-and cytoskeleton (LINC) complex component SUN5. LINC complexes typically reside in the nuclear envelope, the double-membrane ...
• Hierarchical whole-brain modeling of critical synchronization dynamics in the human brain AI翻译
  作者：Myrov, Vladislav; Suleimanova, Alina; Knapic, Samanta; Partanen, Paula; Vesterinen, Maria; Liu, Wenya; Palva, Satu; Palva, J. Matias
  作者单位：Aalto University; University of Helsinki; University of Oulu; University of Glasgow
  摘要：The brain operates at the critical transition between order and disorder which supports optimal information processing. Whole-brain computational modeling is a powerful tool for uncovering the system-level mechanisms behind large-scale brain activity in both healthy and pathological states. However, most previous approaches have focused on either functional connectivity or criticality, making it difficult to capture both aspects simultaneously. Here, we introduce a method based on a Hierarchic...
• Mild SARS-CoV-2 maternal infection in mice induces transient offspring neurodevelopmental aberrance AI翻译
  作者：Tung, Wesley; Yuen, Matthew; Cai, Helen; Cho, Hyesun; Lu, Peiwen; Kliman, Harvey J.; Homer, Robert J.; Herrerias, Alexa; Salla, Nikkita; Rivera, Arianna Rodriguez; Liu, Yuting; Pattabiraman, Kartik; Iwasaki, Akiko
  作者单位：Yale University; Yale University; Yale University; Yale University
  摘要：Maternal viral infection during pregnancy has been identified as a risk factor for psychiatric disorders and neurodevelopmental abnormalities in offspring. With cumulative SARS-CoV-2 infections now numbering in the hundreds of millions globally, there is a need to evaluate the effects of maternal SARS-CoV-2 infection on offspring brain development and behavior. We developed a mouse model of mild COVID-19 during pregnancy in which SARS-CoV-2 infection is restricted to the respiratory tract. Inf...
• Mechanistic insights into dengue virus inhibition by a clinical trial compound NITD-688 (vol 122, e2426922122, 2025) AI翻译
  作者：Wang, Yan; Sun, Long; Fernandes, Luciana; Wang, Yu-Hsiu; Zou, Jing; Franklin, Samuel J.; Hu, Yanping; Palmer, Lee K.; Yeung, Jason; Barriga, Daniela; Russell, William K.; Moquin, Stephanie A.; Shi, Pei-Yong; Skepper, Colin; Xie, Xuping