19期

最新文章

• 3D epithelial cell topology tunes signaling range to promote precise patterning AI翻译
  作者：Paci, Giulia; Berkemeier, Francisco; Baum, Buzz; Page, Karen M.; Mao, Yanlan
  作者单位：University of London; University College London; University of London; University College London; University of Cambridge; University of Cambridge; MRC Laboratory Molecular Biology; University of London; University College London
  摘要：Cell behaviors in multicellular organisms are coordinated via both diffusible molecules and by signals based on direct cell-cell contacts. The mode of cell communication used influences the signaling range. In many developing epithelia, contact-based Notch-Delta lateral inhibition signaling is used to pattern cell fates. While previous work revealed that cells can use protrusions to extend the range of Notch-Delta signaling to alter these patterns, this is not a general feature of epithelia. I...
• Improving the job market in economics (and beyond…) AI翻译
  作者：Rousseau, Peter L.
  作者单位：Vanderbilt University
• Climatic mechanisms underlying a southwestern French Neanderthal refugium at the onset of the last glaciation AI翻译
  作者：Sanchez Goni, Maria Fernanda; d'Errico, Francesco
  作者单位：Centre National de la Recherche Scientifique (CNRS); Universite PSL; Universite de Bordeaux; CNRS - National Institute for Earth Sciences & Astronomy (INSU); Universite de Bordeaux; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); University of Bergen
• Evaluating the statistical realism of LLM-generated social science data AI翻译
  作者：Xie, Yueqi; Liang, Lemeng; Li, Shuzhen; Lu, Yifu; Xiao, Zhiwen; Shi, Mengdi; Huang, Junming; Wang, Mengdi; Xie, Yu
  作者单位：Princeton University; Princeton University; Princeton University; Peking University
  摘要：Large language models (LLMs) hold great promise for generating social science data, potentially expanding the methodological toolkit of quantitative social research. Prior studies have primarily focused on individual-level predictability or behavioral plausibility of LLM-generated data. We propose a framework for assessing the validity of LLM-generated data by returning to the foundational principles of survey research in the social sciences. Just as surveys based on representative samples yie...
• Linkage of nucleotide and functional diversity varies across gut bacteria AI翻译
  作者：Dubinkina, Veronika; Smith, Byron J.; Zhao, Chunyu; Pino, Cindy; Pollard, Katherine S.
  作者单位：Chan Zuckerberg Initiative (CZI); University of California System; University of California San Francisco
  摘要：Understanding the forces shaping genomic diversity within bacterial species is essential for interpreting microbiome evolution, ecology, and host associations. Here, we analyze over one hundred prevalent gut bacterial species using the Unified Human Gut Genome collection to characterize patterns of intraspecific genomic variability. Gene content divergence scales predictably with divergence in core genome single nucleotide polymorphisms (SNPs), though there is substantial variability in evolut...
• D614G reshapes allosteric networks and opening mechanisms of SARS-CoV-2 spikes AI翻译
  作者：Kearns, Fiona L.; Bogetti, Anthony T.; Calvo-Tusell, Carla; Braza, Mac Kevin E.; Casalino, Lorenzo; Gramm, Amanda J.; Braet, Sean; Rosenfeld, Mia A.; Rajapaksha, Harinda; Barker, Bryan; Anand, Ganesh; Chong, Lillian T.; Ahn, Surl-Hee; Amaro, Rommie E.
  作者单位：University of California System; University of California San Diego; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of California System; University of California San Diego; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; University of California System; University of California Davis
  摘要：The severe acute respiratory syndrome coronavirus 2 spike glycoprotein enables infection through a key conformational transition that exposes its receptor binding domain (RBD). Experimental evidence indicates that spike mutations, particularly the early D614G variant, alter the rate of this conformational shift, potentially increasing viral infectivity. We conducted extensive weighted ensemble simulations of the Ancestral, Delta, and Omicron BA.1 spike strains to investigate relationships betw...
• Early-life adversity shapes the relationship between growth and reproduction in free-ranging female rhesus macaques AI翻译
  作者：Petersen, Rachel M.; Patterson, Sam K.; Widdig, Anja; Turcotte, Cassandra M.; Anton, Susan C.; Williams, Scott A.; Romero, Ashly N.; Surratt, Samuel E. Bauman; Ruiz-Lambides, Angelina; Montague, Michael J.; Snyder-Mackler, Noah; Brent, Lauren J. N.; Higham, James P.; Lea, Amanda J.
  作者单位：Vanderbilt University; Vanderbilt University; New York University; University of Notre Dame; Leipzig University; Max Planck Society; University of Calgary; University of Calgary; Alberta Childrens Hospital; University of Calgary; University Calgary Hospital; University of Arizona; University of Arizona Health Sciences; University of Puerto Rico; University of Puerto Rico Mayaguez; University of Pennsylvania; Pennsylvania Medicine; Arizona State University; Arizona State University-Tempe; Arizona State University; Arizona State University-Tempe; Arizona State University; Arizona State University-Tempe; Arizona State University; Arizona State University-Tempe; University of Exeter; Vanderbilt University
  摘要：Life history theory predicts that organisms allocate resources across physiological processes to maximize fitness. Under this framework, early-life adversity (ELA) which limits energetic capital could shape investment in growth and reproduction, ultimately contributing to evolutionary fitness. Integrating 64 y of long-term demographic information with cross-sectional behavioral and physiological data from female rhesus macaques (Macaca mulatta; n = 163 to 2,105 females depending on the analysi...
• A PKA-selective inhibitor captures an open but more ordered conformation of the PKA catalytic subunit AI翻译
  作者：Bruystens, Jessica G. H.; Wu, Jian; Tan, Gerald; Bertinetti, Daniela; Zenn, Hans-Michael; Zimmermann, Bastian; Chen, Lisa; Koeckenberger, Johannes; Massaro, Federica; Sankaran, Banumathi; Walters, Matthew S.; Veglia, Gianluigi; Ferguson, Fleur M.; Herberg, Friedrich W.; Taylor, Susan S.
  作者单位：University of California System; University of California San Diego; Universitat Kassel; University of California System; University of California San Diego; University of Minnesota System; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California San Diego; University of California System; University of California San Diego
  摘要：The structure of the catalytic subunit of cAMP-dependent protein kinase (PKA-C), a prototype for the protein kinase superfamily, laid the foundation for the development of targeted kinase inhibitors. Here we describe the structure and biophysical characterization of a PKA-C complex with BLU0588, a small PKA-selective inhibitor. The high-resolution crystal structure not only captures the inhibitor's unusual T-shaped geometry, but also shows how the four rings of BLU0588 serve as surrogates for ...
• Repeated snowball-hothouse cycles within the Neoproterozoic Sturtian glaciation AI翻译
  作者：Minsky, Charlotte; Wordsworth, Robin; Johnston, David T.; Knoll, Andrew H.
  作者单位：Harvard University; Harvard University; Harvard University
  摘要：The Neoproterozoic Era was a pivotal era of Earth's history in which multiple severe glaciations profoundly influenced the biosphere, but explaining the duration and nature of these events remains a major challenge. Notably, geochronology indicates that the Sturtian glaciation lasted for similar to 56 Myr-far longer than can be accommodated by canonical Snowball or Slushball models. Here we use a coupled box model of the Neoproterozoic climate and carbon cycle to develop a hypothesis for Sturt...
• Decoding the structure of GPR151 via NELiS AI翻译
  作者：Wang, Yumeng; Fan, Luyu; Song, Qianqian; Li, Yaning; Jin, Jiayu; Zhao, Qiaoyu; Gu, Weijie; Shi, Xiangyi; Li, Dianfan; Cong, Yao; Wang, Sheng
  作者单位：Chinese Academy of Sciences; Center for Excellence in Molecular Cell Science, CAS; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Sun Yat Sen University; Chinese Academy of Sciences; Center for Excellence in Molecular Cell Science, CAS; University of Chinese Academy of Sciences, CAS
  摘要：Structure determination of orphan G protein-coupled receptors (GPCRs) is hindered by lack of known ligands and their inherent instability during purification. Conventional thermostability screening requires ligands or purified protein, limiting its utility for orphan GPCRs. Here, we present the Nb6-Enabled Ligand-Free Stabilization Platform (NELiS)-a ligand- and purification-independent method for identifying stabilizing mutations. Applied to GPR151, an orphan GPCR enriched in habenula and imp...