19期

最新文章

• Regulation of antiviral and antitumor immunity by the BRCA1 pseudogene in human cancers AI翻译
  作者：Han, Yoo Jane; Zhang, Jing; Shariff, Maryam; Wu, Sulin; Khramtsova, Galina; Nguyen, Long Chi; Peiffer, Daniel S.; Li, Nansheng; Lewicka, Anna; Moore, Matthew; Piccirilli, Joseph A.; Olopade, Olufunmilayo I.
  作者单位：University of Chicago; University of Chicago; University of Chicago; University of Chicago; University of Chicago
  摘要：Pseudogenes have been regarded as nonfunctional byproducts of evolutionary processes. However, emerging evidence indicates that pseudogenes perform diverse biological roles in human physiology and pathology. We identified the BRCA1 pseudogene (BRCA1P1), a fusion pseudogene derived from the BRCA1 tumor suppressor and RPLP1 ribosomal protein genes, as an immunoregulatory RNA in breast cancer. In this study, we show that BRCA1P1 expression varies across multiple cancer cell types, with no signifi...
• Can privacy technologies replace cookies? Ad revenue in a field experiment AI翻译
  作者：Gu, Zhengrong; Johnson, Garrett A.; Kobayashi, Shunto J.
  作者单位：Boston University
  摘要：Digital advertising finances much of the open web, yet relies on tracking technologies that regulators increasingly seek to restrict. In response, industry has developed privacy-enhancing technologies intended to preserve advertising performance while limiting data collection, but their economic effects remain largely untested. We study this question using an open, industry-wide field experiment jointly overseen by Google and the UK Competition and Markets Authority, in which Chrome users were...
• Social cognition and interpersonal violence AI翻译
  作者：Kang, Megan; Edin, Kathryn; Ludwig, Jens; Nelson, Timothy; Mullainathan, Sendhil
  作者单位：Johns Hopkins University; Princeton University; Princeton University; University of Chicago; National Bureau of Economic Research; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
  摘要：Why do some people resort to violence while others in similar circumstances do not? Drawing on 99 in-depth interviews with men from high-violence Chicago neighborhoods who participated in a community violence intervention, we examine how past exposure to violence shapes the social cognitions that influence future involvement in violence-through the schemas and scripts people use to interpret social situations and guide behavior. We identify three specific social cognitions that respondents ass...
• Attention control ability is associated with frontoparietal control network interactions AI翻译
  作者：Seeburger, Dolly T.; Tsukahara, Jason S.; Xu, Nan; Ahluwalia, Vishwadeep; Keilholz, Shella D.; Engle, Randall W.
  作者单位：University System of Georgia; Georgia Institute of Technology; University of North Carolina; University of North Carolina Wilmington; University System of Maryland; University of Maryland College Park; University System of Georgia; Georgia Institute of Technology; Emory University; University System of Georgia; Georgia Institute of Technology
  摘要：Attention control predicts academic achievement, professional success, and health outcomes. However, the neural basis of stable, individual differences in attention control remains unclear. Prior research has emphasized momentary fluctuations in attentional engagement, often overlooking enduring individual differences. Here, we applied the quasi-periodic pattern analysis of infraslow functional magnetic resonance imaging (fMRI) dynamics in a large sample (N = 196) to test whether trait attenti...
• Transmembrane ROOM proteins ensure rooms for germ cells by maintaining intercellular bridges AI翻译
  作者：Sugiura, Kenta; Kawasaki, Ichiro; Kosako, Hidetaka; Sato, Ken
  作者单位：Gunma University; Tokushima University
  摘要：Germ cells of diverse species form a syncytium, which is a multinucleated cell complex, and share cytoplasmic components via intercellular bridges. Here, we demonstrate that the paralogous transmembrane proteins ROOM-1 and ROOM-2, identified through the proteomic analysis of maternal membrane proteins, are essential for the maintenance of germ cell compartments from the rachis of Caenorhabditis elegans gonads. Although animals lacking each protein are fertile, the loss of both proteins resulte...
• Compositionality and systematicity emerge from iterated learning in deep linear networks AI翻译
  作者：Jarvis, Devon; Klein, Richard; Rosman, Benjamin; Saxe, Andrew M.
  作者单位：University of Witwatersrand; University of Witwatersrand; University of London; University College London; University of London; University College London
  摘要：Humans have a remarkable ability to systematically generalize-reasoning about new situations by combining aspects of previous experiences. Language provides one of the primary examples of this ability and modern machine learning has drawn much inspiration from linguistics. A recent example is iterated learning, a procedure where generations of networks learn from the output of earlier learners. The result is a refinement of the network's language or output labels for given inputs toward compos...
• The radical SAM enzyme EpeE exhibits distinct site reactivity during the biosynthesis of the RiPP natural product epipeptide (vol 123, e2529780123, 2026) AI翻译
  作者：Walls, William G.; Yang, Hao; Ho, Madeline B.; Broderick, William E.; Hoffman, Brian M.; Broderick, Joan B.
• Tropism of SARS-CoV-2 for human cortical astrocytes (vol 119, e2122236119, 2022) AI翻译
  作者：Andrews, Madeline G.; Mukhtar, Tanzila; Eze, Ugomma C.; Simoneau, Camille R.; Ross, Jayden; Parikshak, Neelroop; Wang, Shaohui; Zhou, Li; Koontz, Mark; Velmeshev, Dmitry; Siebert, Clara-Vita; Gemenes, Kaila M.; Tabata, Takako; Perez, Yonatan; Wang, Li; Mostajo-Radji, Mohammed A.; de Majo, Martina; Donohue, Kevin C.; Shin, David; Salma, Jahan; Pollen, Alex A.; Nowakowski, Tomasz J.; Ullian, Erik; Kumar, G. Renuka; Winkler, Ethan A.; Winkler, A.; Crouch, Elizabeth E.; Ott, Melanie; Kriegstein, Arnold R.
• Design of an ultrabright biosensor for dynamic imaging of kinase activity in cells AI翻译
  作者：Li, Xiaoquan; Tan, Sophia K.; Chung, Chan-, I; Hatstat, A. Katherine; Zhao, Qian; Luo, Jingyu; DeGrado, William F.; Shu, Xiaokun
  作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; UCSF Medical Center; UCSF Helen Diller Family Comprehensive Cancer Center
  摘要：Protein kinases regulate almost every major signaling pathway. Visualizing spatiotemporal dynamics of kinase activity is thus essential to understand cell signaling. Here, we report a de novo-designed activity reporter of kinase, dubbed NOVARK, which contains a single polypeptide chain with multiple modular motifs that act as specific kinase substrates and reporters. NOVARK undergoes phosphorylation-induced higher-order assembly, which are detectable as ultrabright green fluorescent protein (G...
• Convergent antibody solutions revealed by focused humanized repertoires AI翻译
  作者：Perra, Maria Maddalena; Chaudhuri, Jayanta
  作者单位：Memorial Sloan Kettering Cancer Center