22期

最新文章

• Theory of chromosome structural dynamics by processive loop extrusion AI翻译
  作者：Cao, Zhiyu; Du, Chaoqun; Hou, Zhonghuai; Wolynes, Peter G.
  作者单位：Rice University; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Rice University; Rice University
  摘要：The processivity of Structural Maintenance of Chromosome complexes defines the characteristic run length and lifetime of loop extrusion events, which set up the large-scale architecture of chromosomes. We introduce an active, non-Markovian mechanistic model that explicitly incorporates motor processivity to provide a statistical mechanical treatment that identifies the nontrivial effects induced by the processive character of such active motors. At low activity, in interphase, processive loop ...
• Evolution induced state shifts in a long-term microbial community experiment AI翻译
  作者：Kivikoski, Mikko; Cairns, Johannes; Hogle, Shane L.; Pausio, Sanna; Becks, Lutz; Mustonen, Ville; Hiltunen, Teppo
  作者单位：University of Helsinki; University of Helsinki; University of Turku; University of Turku; University of Konstanz
  摘要：Biological communities are complex, dynamic systems that underpin ecosystem functionality, yet their long-term dynamics and predictability remain poorly understood. Understanding how Darwinian evolution shapes these systems through eco-evolutionary feedback is a central challenge in ecology and evolution. Experimental studies using simplified microbial assemblages have yielded important insights into the ecological principles governing community states. However, an important knowledge gap is h...
• Multiple defects in macrophage antibacterial responses support intracellular survival of Mycobacterium abscessus in cystic fibrosis AI翻译
  作者：Tarique, Abdullah A.; Emming, Stefan; Kelk, Dean; Logan, Jayden; Ramanth, Divya; Dalton, Emma K.; Das Gupta, Kaustav; Blake, Tamara; Curson, James E. B.; Afroz, Syeda Farhana; Sweet, Matthew J.; Wainwright, Claire E.; Kapetanovic, Ronan; Kremer, Laurent; Bell, Scott C.; Fantino, Emmanuelle; Sly, Peter D.
  作者单位：University of Queensland; University of Queensland; University of Queensland; Childrens Health Queensland Hospital & Health Service; Queensland Childrens Hospital; INRAE; Universite de Tours; Universite de Montpellier; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Universite de Montpellier; Institut National de la Sante et de la Recherche Medicale (Inserm); Gold Coast University Hospital; Griffith University
  摘要：The prevalence of Mycobacterium abscessus (MABS) infections in people with cystic fibrosis (pwCF) is increasing. Macrophages are key phagocytic cells that recognize bacteria via cell surface receptors, engulf them into phagosomes, and then utilize diverse killing strategies. Here, we used human primary monocyte-derived macrophages (MDMs) from healthy controls (HCs) and pwCF to investigate how they processed and killed MABS. Expression of phagocytosis-related pattern recognition receptors (TLR2...
• Flipping plankton AI翻译
  作者：Wade, Bridget S.; Pearson, Paul N.; King, David J.; Luciani, Valeria
  作者单位：University of London; University College London; University of Ferrara
  摘要：Sudden, global reversals in shell coiling direction are a striking and recurrent feature in the fossil record of planktonic foraminifera (marine zooplankton), yet their evolutionary significance has been a mystery. Because coiling direction is a simple, binary character, such shifts have often been interpreted as environmentally induced phenotypic responses rather than indicators of evolutionary change, although it is increasingly evident that genetic variants can have different coiling prefer...
• Epstein-Barr virus (EBV) infection causes human germinal center B cell-derived lymphomas in the absence of EBNA2 expression AI翻译
  作者：Wang, Chunyan; Bristol, Jillian A.; Nelson, Scott E.; Chen, Tony; Hendrickson, Charlotte; Baiu, Dana C.; Riel, Mariah; Hayes, Mitch; Ranheim, Erik A.; Gumperz, Jenny E.; Johannsen, Eric C.; Kenney, Shannon C.
  作者单位：University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison
  摘要：EBV is associated with human B cell lymphomas, including Burkitt lymphomas (BLs), diffuse large B cell lymphomas (DLBCLs), Hodgkin lymphomas (HLs), and Plasmablastic lymphomas (PLs). EBV+ lymphomas in immunocompetent humans are usually derived from germinal center (GC)-experienced B cells and have stringent latency forms that do not express the viral transforming protein, EBNA2. Human EBV+ lymphomas that lack EBNA2 expression are largely driven by the viral LMP1 and LMP2A proteins, which activ...
• Explaining the universality of biological thermal responses AI翻译
  作者：Arroyo, Jose Ignacio; Kempes, Christopher; West, Geoffrey; Marquet, Pablo A.
  作者单位：The Santa Fe Institute; Universidad de Chile; Pontificia Universidad Catolica de Chile
• Lipid residue analysis reveals divergent culinary practices in Japan and Korea at the dawn of intensive agriculture (Vol 122, e2504414122, 2025) AI翻译
  作者：Craig, Oliver E.; Lundy, Jasmine; Bondetti, Manon; Nicholson-Lailey, Sesha; Murakami, Natsuki; Suzuki, Miho; Stevens, Chris; Lucquin, Alexandre; Talbot, Helen M.; Son, Joon-ho; Fujio, Shinichiro; Sakamoto, Minoru; Yamashita, Yusuke; Kobayashi, Kenichi; Crema, Enrico R.; Shoda, Shinya
  作者单位：University of York - UK; University of London; University College London; Korea University; Chuo University; University of Cambridge
• Cross-linking of collagen fibrils leads to preferential gap zone mineralization in vitro (vol 123, e2528176123, 2026) AI翻译
  作者：Gao, Ruixin; DiCecco, Liza-Anastasia; Zhong, Liyang; Wojtas, Magdalena; Carneiro, Karina; Grandfield, Kathryn; Sone, Eli D.
  作者单位：University of Toronto; McMaster University; University of Waterloo; Wroclaw University of Science & Technology; University of Toronto; McMaster University; University of Toronto
• A negative-hydrated constriction zone is revealed in the active state of the Hv1 channel AI翻译
  作者：Alvear-Arias, Juan J.; Basaez, Dario; Carmona, Emerson M.; Galizia, Luciano; Fernandez, Miguel; Pena-Pichicoi, Antonio; Ozu, Marcelo; Jorquera, Orlando; Latorre, Ramon; Neely, Alan; Garate, Jose Antonio; Gonzalez, Carlos
  作者单位：University of Buenos Aires; University of Buenos Aires; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Universidad de Valparaiso; University of Washington; University of Washington Seattle; Universidad San Sebastian; Universidad San Sebastian
  摘要：The voltage-gated proton (H(v)1) channel is crucial in regulating cellular pH, yet the mechanism underlying proton permeation remains controversial. A deeper understanding of the differences between the channel's active and resting states is essential for clarifying its conductive properties. In this study, we employ a combination of molecular dynamics simulations, site-directed mutagenesis, and electrophysiological recordings to investigate what changes occur in an active H(v)1 channel and ho...
• An engineered closed-shell, two-component, 480-subunit nucleocapsid AI翻译
  作者：Levasseur, Mikail D.; Terasaka, Naohiro; Steinauer, Angela; Tetter, Stephan; Pfister, Sara; Meier, Beat H.; Hilvert, Donald
  作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich
  摘要：Self-assembling protein cages are valuable nanoscale containers for biotechnology and medical applications. Two-component systems are especially attractive due to their potential for functional complexity. In this study, we demonstrate that the subunits of the 240-subunit nucleocapsid NC-4, which was previously evolved to package and protect its encoding mRNA, can be split into two fragments without disrupting cage assembly or structure, generating a two-component, 480-subunit capsid. This mod...