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作者:Cantisani, Andrea; Schmutz, Jan B.; Marques-Quinteiro, Pedro; Dall'Amico, Lorenzo; Cattuto, Ciro; Antino, Mirko; Eppich, Walter J.; Stegmayer, Katharina; Walther, Sebastian
作者单位:University of Bern; University Hospital of Bern; University of Zurich; Lusofona University; University of Tras-os-Montes & Alto Douro; Complutense University of Madrid; University of Melbourne; University of Wurzburg
摘要:Long-duration space missions expose crews to extreme psychological and social stressors due to prolonged isolation and confinement. To examine how such conditions impact individual and team functioning, we studied a 10-mo Antarctic overwintering mission at Concordia Station, an analog for spaceflight, using self-report measures and wearable proximity sensors. Twelve crew members were assessed at four time-points. Results revealed a progressive increase in feelings of loneliness and conflict, w...
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作者:Domen, Jos; Voskoboynik, Yotam; Levy, Tom; Domen, Erica M.; Ishizuka, Katherine J.; Palmeri, Karla J.; Anselmi, Chiara; Rolander, Thomas; Neff, Norma F.; Detweiler, Angela M.; Weissman, Irving L.; Gandy, Kimberly L.; Sahoo, Debashis; Voskoboynik, Ayelet
作者单位:Stanford University; Stanford Medicine; Stanford University; Stanford University; University of California System; University of California San Diego; University of California System; University of California Berkeley; Chan Zuckerberg Initiative (CZI); University of California System; University of California San Diego; University of California System; University of California San Diego
摘要:Endogenous bioelectric currents regulate development and regeneration, but their influence on organismal longevity and stem cell-mediated repair is not well understood. We demonstrate that a brief, clinically safe pulse of electrical current (PEC) produces lasting rejuvenation in the colonial chordate Botryllus schlosseri. In this species where all differentiated tissues are replaced weekly and progenitor populations mediate the weekly de novo generation of new organs, organismal aging is dire...
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作者:Evans, Samuel; Price, Cathy J.; Diedrichsen, Jorn; Twomey, Tae; Beedie, Indie; Fraser, Maggie; MacSweeney, Mairead
作者单位:University of London; University College London; University of London; University College London; University of London; University College London; Western University (University of Western Ontario); Western University (University of Western Ontario); Western University (University of Western Ontario)
摘要:Reading is central to academic and vocational success. Some deaf children face reading challenges due to limited access to spoken or signed language. Robust phonological representations are key to reading development in hearing children. Spoken language phonology may be one of many contributors to reading development in deaf children. Indeed, speechreading ability correlates with reading skill in both deaf and hearing individuals, suggesting it is linked to reading development regardless of he...
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作者:Ritson-Williams, R.; Mumby, P. J.; Steneck, R. S.
作者单位:California State University System; California State University Northridge; University of Queensland; University of Maine System; University of Maine Orono
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作者:Seminara, Giovanni
作者单位:University of Genoa
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作者:Stanoi, Ovidia A.; Cosme, Danielle; Jovanova, Mia; Kang, Yoona; Corbani, Faustine; McGowan, Amanda L.; Carreras-Tartak, Jose; Resnick, Anthony; Bearman, Peter S.; Boyd, Zachary M.; Bassett, Dani S.; Lydon-Staley, David M.; Mucha, Peter J.; Falk, Emily B.; Ochsner, Kevin N.
作者单位:University of Pennsylvania; University of Pennsylvania; University of St Gallen; Swiss Federal Institutes of Technology Domain; ETH Zurich; Rutgers University System; Rutgers University New Brunswick; Rutgers University Camden; Princeton University; Columbia University; Brigham Young University; University of Pennsylvania; Dartmouth College; University of Pennsylvania; University of Pennsylvania; Columbia University
摘要:Individuals are motivated to increase their social status. To succeed in this pursuit, people must track information about others in their social sphere, monitor group norms, and adjust their behavior strategically. This study employed functional MRI and ecological momentary assessment methods in a sample of 92 college students belonging to 9 social groups to elucidate the neural mechanisms underlying these processes and their relationship to conformity in the context of alcohol use. When youn...
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作者:Brandt, Benjamin; Schwartz, Sebastian; Schwenkert, Serena; Kramer, Moritz; Om, Kuenzang; Engstler, Carina; Klingl, Andreas; Jahns, Peter; Meyer, Etienne H.; DeTar, Rachael A.; Eirich, Jurgen; Finkemeier, Iris; Cousins, Asaph B.; Kunz, Hans-Henning
作者单位:University of Munich; University of Munich; University of Munich; Washington State University; University of Munich; Heinrich Heine University Dusseldorf; Martin Luther University Halle Wittenberg; Colorado State University System; Colorado State University Fort Collins; University of Munster
摘要:In bacteria, protein mistranslation can improve stress tolerance. Mitochondria and plastids evolved from bacteria and use a prokaryotic-type expression machinery to synthesize proteins. Interestingly, fungi and animal mitochondria are highly sensitive to mistranslation, which for instance manifests in lethal mitochondrial cardiomyopathy disorder. The response in plant cells is unknown. Glutaminyl-transfer RNAs (Gln-tRNAGln) of bacteria and endosymbiotic organelles are synthesized indirectly. I...
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作者:Edger, Patrick P.; Body, Melanie J. A.; De Donno, Sonia; Platts, Adrian E.; Wang, Jianrong; Jiang, Jiming
作者单位:Michigan State University; Michigan State University; Michigan State University; Michigan State University; Michigan State University
摘要:Polyploidy, also known as whole genome duplication, is a major evolutionary force in plants, driving diversification and the generation of novel phenotypic variation, including superior abiotic and biotic stress tolerance. The enhanced stress resilience observed in certain polyploids is hypothesized to arise from dynamic epigenetic and genetic changes, including variations in gene content and cis-regulatory elements (CREs), that emerge following polyploidization. These changes directly impact ...
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作者:Barko, Kelly N.; Shelton, Micah A.; Kropp, Dawson R.; Pham, Thien Quy; Rainville, Jennifer R.; Xue, Xiangning; Tseng, George C.; Hodes, Georgia E.; Seney, Marianne L.
作者单位:Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Virginia Polytechnic Institute & State University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
摘要:Major depressive disorder (MDD) is characterized by symptom heterogeneity and sex differences in prevalence. To gain insight into these sex differences, we utilized the subchronic variable stress paradigm (SCVS) in which female mice are susceptible, while males are behaviorally resilient. We used the Four Core Genotypes mice to differentiate between sex chromosome complement (XX vs. XY) and gonad type (ovaries vs. testes) in stress susceptibility, uncoupling these factors by removing the teste...
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作者:Garcia, Guadalupe C.; Bartol, Thomas M.; Kirk, Lyndsey M.; Badala, Priyal; Harris, Kristen M.; Sejnowski, Terrence J.
作者单位:Salk Institute; University of Texas System; University of Texas Austin; University of California System; University of California San Diego
摘要:Long-term potentiation (LTP) is a lasting form of synaptic plasticity that can persist for hours or even days. It is associated with structural changes in both the presynaptic terminal and the postsynaptic spine. Presynaptically, the number and distribution of synaptic vesicles (SVs) affect synaptic efficacy. How the functional changes in synaptic efficacy after the induction of LTP are mirrored by identifiable structural alterations in the SV cluster is not fully understood. Here, we interrog...