6791期

最新文章

• Filling the US gap at science-policy bodies AI翻译
  作者：McElwee, Pamela
  作者单位：Rutgers University System; Rutgers University New Brunswick
• Agentic AI and the next intelligence explosion AI翻译
  作者：Evans, James; Bratton, Benjamin; Aguera y Arcas, Blaise
  作者单位：Alphabet Inc.; Google Incorporated; University of Chicago; The Santa Fe Institute; University of California System; University of California San Diego
• Spatial and morphological organization of mitochondria in neurons across a connectome AI翻译
  作者：Sager, Garrett; Pfeiffer, Paul; Wu, Heng; Pallasdies, Fabian; Gowers, Robert; Ravikumar, Snusha; Wu, Elizabeth; Colon-Ramos, Daniel; Schreiber, Susanne; Clark, Damon A.
  作者单位：Yale University; Humboldt University of Berlin; Yale University; Yale University; Yale University; Yale University; Yale University
  摘要：Neuronal function depends on mitochondria, but little is known about their organization across neurons. Using an electron microscopy Drosophila connectome, we uncovered quantitative rules governing the morphology and positioning of hundreds of thousands of mitochondria across thousands of neurons. We discovered that mitochondrial morphological features are specific to cell and neurotransmitter type, which provides fingerprints to identify neurons. Mitochondria are positioned with 2- to 3-micro...
• From chronic pain to depression: Neurogenesis-driven microglial remodeling in the hippocampal dentate gyrus AI翻译
  作者：Ding, Ming; Xiang, Shitong; Zhang, Yuqing; Wei, Lei; Weng, Yuanfeng; Zhang, Xueting; Ni, Yiling; Zhang, Yuwen; Wang, Qianfeng; Hou, Ruiqing; Du, Huaihao; Chio, Ka Kei; Zhang, Wei; Wang, He; Jia, Tianye; Wu, Yi; Feng, Jianfeng; Robbins, Trevor W.; Xiao, Xiao
  作者单位：Fudan University; Fudan University; Fudan University; Fudan University; Fudan University; Chinese Academy of Sciences; Shanghai Institute of Nutrition & Health, CAS; University of Chinese Academy of Sciences, CAS; Peking University; Peking University; University of Warwick; University of Cambridge
  摘要：Chronic pain often evolves into depression and anxiety, yet mechanisms linking sensory distress to affective dysfunction remain unclear. Integrating human neuroimaging from the UK Biobank with a rodent model, we uncovered biphasic hippocampal remodeling. Hippocampal volume increased during early pain stages, with paradoxical cognitive improvements, but declined with comorbid depression. In rodents, the dentate gyrus (DG) acted as a hub governing this transition: Lesions of DG prevented affecti...
• Strong light emission with a twist Stacks of boron nitride sheets can be arranged to emit deep ultraviolet light AI翻译
  作者：Gil, Bernard; Cassabois, Guillaume
  作者单位：Universite de Montpellier; Centre National de la Recherche Scientifique (CNRS); Institut Universitaire de France
• Host-derived nitrate fuels indole production by Escherichia coli to drive chronic kidney disease progression AI翻译
  作者：Lee, Jee-Yon; Mahan, Scott P.; Parente de Carvalho, Thaynara; Nguyen, Henry; Singai, Chonikarn; Camacho, Lizbeth; Tekeli, Mert; Kwon, Yu-Jin; Lee, Ji-Won; Santos, Renato L.; Tsolis, Renee M.; Winter, Sebastian E.; Baumler, Andreas J.
  作者单位：University of California System; University of California Davis; Universidade Federal de Minas Gerais; Yonsei University; Severance Hospital; Yonsei University Health System; Yonsei University; Severance Hospital; Yonsei University Health System; University of California System; University of California Davis
  摘要：Chronic kidney disease (CKD) is linked to an elevated fecal abundance of Enterobacteriaceae, but the ecological drivers of this shift and its impact on disease progression remain unclear. The uremic toxin indoxyl sulfate is produced from microbiota-derived indole in the liver. Here, we found that in mice with adenine-induced CKD, impaired clearance of indoxyl sulfate elevated mucosal expression of the gene encoding inducible nitric oxide synthase (iNOS). The resulting rise in luminal nitrate l...
• Research security policy needs clear guidelines AI翻译
  作者：Wagner, Caroline S.; Simon, Denis F.
  作者单位：University System of Ohio; Ohio State University; Tsinghua University
• Wildfire: A growing threat to water security AI翻译
  作者：Zhai, Yujia; Gong, Mimi; Tao, Yu; Zhou, Zhongbo; Liu, Gang
  作者单位：Beijing Normal University; Beijing Normal University; Harbin Institute of Technology; Southwest University - China; Chinese Academy of Sciences; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
• Highly efficient, deep-ultraviolet luminescence in hBN moiré quantum wells AI翻译
  作者：Hong, Chengyun; Zhao, Fangzhou; Song, Su-Beom; Yoon, Sangho; Jeon, Seong-Joon; Khan, M. Ajmal; Tao, Ye; Yang, Dong-Hwan; Lee, Wanhee; Kim, Junho; Yang, Sera; Cho, Hyungseob; Lee, Sumin; Min, Seok Young; Watanabe, Kenji; Taniguchi, Takashi; Yoo, Seunghyup; Cho, Changsoon; Choi, Si-Young; Hirayama, Hideki; Xian, Lede; Jo, Moon-Ho; Rubio, Angel; Kim, Jonghwan
  作者单位：Institute for Basic Science - Korea (IBS); Pohang University of Science & Technology (POSTECH); Max Planck Society; RIKEN; Korea Advanced Institute of Science & Technology (KAIST); National Institute for Materials Science; National Institute for Materials Science; Pohang University of Science & Technology (POSTECH); Songshan Lake Materials Laboratory; Pohang University of Science & Technology (POSTECH); Simons Foundation; Flatiron Institute; Simons Foundation; Flatiron Institute
  摘要：Twisted stacking of two-dimensional van der Waals (vdW) semiconductors creates moir & eacute; superlattices, which provides unprecedented control over quantum states and their light-matter interactions. We demonstrate that a simple twist interface between two single-crystalline bulks of hexagonal boron nitride (hBN) creates moir & eacute; quantum wells (QWs) embedded in a three-dimensional vdW structure. hBN moir & eacute; QWs strongly confine charge carriers under both optical excitation and ...
• China demands evidence for traditional medicine injections AI翻译
  作者：Normile, Dennis