6791期

最新文章

• Hidden culprit found for puzzling static electricity: Trace surface contamination determines how identical materials exchange charge AI翻译
  作者：Berkowitz, Rachel
• Overlapping currents can tune the deep brain AI翻译
  作者：Smith, Jennie Erin
• Department of Energy labs embrace Genesis AI push AI翻译
  作者：Cho, Adrian
• Self-serving tweaks hurt science AI翻译
  作者：Venkataraman, Shankar
  作者单位：Bentley University
• Hypothalamic clock governs circadian pain AI翻译
  作者：Wei, Hong-Rui; Lou, Qianqian; Li, Le-Xian; Tang, Lan; Wu, Run-Jie; Li, Hong-Yu; Jiang, Ai-Jun; Yang, Xin-Lu; Gao, Wei; Zhao, Xin-Yi; Han, Liuhu; Mao, Yu; Qun, Sen; Luo, Yanli; Qian, Junchao; Jin, Yan; Zhang, Zhi
  作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Anhui Medical University; Anhui Medical University; Shanghai Jiao Tong University; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Anhui Medical University
  摘要：Chronic pain exhibits circadian rhythms in humans, but the mechanisms underlying such rhythmicity remain unclear. Here, we found daily oscillations in the nociceptive thresholds in a mouse model of neuropathic pain, driven by a rhythmic circuit from the master clock in the hypothalamus to the descending analgesia system. In the daytime (resting phase), higher vasoactive intestinal peptide (VIP) neuronal activity in suprachiasmatic nucleus (SCNVIP) activates a signaling pathway involving the pa...
• Overcoming T cell tolerance to tumor self-antigens through catch-bond engineering AI翻译
  作者：Chen, Xiaojing; Mao, Zhiyuan; Kolawole, E. Motunrayo; Persechino, Margherita; Jude, Kevin M.; Ogishi, Masato; Mo, Kelvin C.; McLaughlin, Jami; Cheng, Donghui; Xiang, Xinyu; Yang, Xinbo; Gee, Caitlin; Liu, Shiqin; Yang, Aerin; Obenaus, Matthias; Wang, Nan; Noguchi, Miyako; Stoyanova, Tanya; Lee, John K.; Good, Zinaida; Latorraca, Naomi R.; Evavold, Brian D.; Witte, Owen N.; Garcia, K. Christopher
  作者单位：Stanford Medicine; Stanford University; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; Utah System of Higher Education; University of Utah; Columbia University; Cornell University; Weill Cornell Medicine; NewYork-Presbyterian Hospital; Stanford Medicine; Stanford University; Stanford Medicine; Stanford University; Howard Hughes Medical Institute; Stanford Medicine; Stanford University; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California Los Angeles Medical Center; Stanford University; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; UCLA Jonsson Comprehensive Cancer Center; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; Stanford Medicine; Stanford University
  摘要：T cells are often weakly responsive to tumor self-antigens because of central tolerance, constraining their ability to eliminate tumors. We exploited mechanical force to engineer a weakly reactive T cell receptor (TCR) specific for a nonmutated tumor-associated antigen (TAA), prostatic acid phosphatase (PAP). We identified a catch-bonding hotspot whose mutation enhanced T cell activity by increasing TCR-pMHC (peptide-major histocompatibility complex) bond lifetime while preserving physiologica...
• Resetting of a tandem microRNA156 enables vegetative perennial growth in rice AI翻译
  作者：Dai, Bingxin; Lv, Danfeng; Chen, Erwang; Gu, Zhoulin; Guo, Dongling; Li, Yan; Zhang, Yaoxin; Liu, Kun; Wang, Ahong; Zhao, Qiang; Zhao, Yan; Hou, Qingqing; Wang, Yongchun; Feng, Qi; Fan, Danlin; Zhou, Congcong; Tian, Qilin; Wang, Zixuan; Wang, Jia-Wei; Han, Bin
  作者单位：Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS; Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS; ShanghaiTech University
  摘要：Annual cultivated rice was domesticated from perennial wild rice, yet the genetic mechanism of perennial growth habit remains unclear. Using introgression lines of wild and cultivated rice, we identified the Endless Branches and Tillers (EBT1) locus, comprising tandem microRNA156 genes (MIR156BC). This locus is responsible for floral reversion and vegetative propagation contributing to perennial growth in wild rice. The wild rice allele EBT1W1943 exhibits higher chromatin accessibility and low...
• United States cuts ties with WHO's cancer research arm AI翻译
  作者：Kaiser, Jocelyn
• Live-cell single-molecule dynamics of eukaryotic RNA polymerase machineries AI翻译
  作者：Ling, Yick Hin; Liang, Chloe; Wang, Sixiang; Wu, Carl
  作者单位：Johns Hopkins University; Johns Hopkins University; Johns Hopkins Medicine
  摘要：Eukaryotic gene expression is orchestrated by RNA polymerases (RNAPI, II, and III) and associated factors, yet their real-time dynamics remain obscure. Using single-molecule tracking in living yeast, we quantified the kinetics of 58 proteins encompassing three RNAP machineries. RNAPI and RNAPIII preinitiation complexes (PICs) engage in long-lived chromatin interactions, contrasting with transient RNAPII PICs. We further report kinetics of RNAPII-associated factors for elongation, histone modif...
• Debate explodes over key early American site AI翻译
  作者：Wade, Lizzie