6790期

最新文章

• High-throughput single-cell omics using semipermeable capsules AI翻译
  作者：Baronas, Denis; Norvaisis, Simonas; Zvirblyte, Justina; Leonaviciene, Greta; Mikulenaite, Vincenta; Goda, Karolis; Kaseta, Vytautas; Sablauskas, Karolis; Griskevicius, Laimonas; Juzenas, Simonas; Mazutis, Linas
  作者单位：Vilnius University; State Research Institute Centre for Innovative Medicine; Vilnius University; Vilnius University; Umea University
  摘要：Biological systems are inherently complex and heterogeneous. Deciphering this complexity increasingly relies on high-throughput single-cell omics methods and tools that efficiently probe the cellular phenotype and genotype. Here, we present a versatile technology based on semipermeable capsules (SPCs) tailored for a variety of high-throughput nucleic acid assays, including single-cell genome and mRNA sequencing, and fluorescence-activated cell sorting-based isolation of individual transcriptom...
• Journals can help protect animal welfare AI翻译
  作者：Carbone, Larry
• Journals can help protect animal welfare AI翻译
  作者：Vignieri, Sacha
• Strong and brittle lithium dendrites AI翻译
  作者：Ai, Qing; Zhang, Boyu; Liu, Xing; Shin, Bongki; Guo, Wenhua; Gao, Guanhui; Zhao, Lihong; Weng, Xintong; Fang, Qiyi; Zhai, Tianshu; Steinbach, Doug; Zhu, Yifan; Liu, Yifeng; Wang, Fan; Tian, Xiaoyin; Guo, Hua; Zhang, Youtian; Zhao, Xuan; Han, Yimo; Tang, Ming; Yao, Yan; Zhu, Ting; Gao, Huajian; Lou, Jun
  作者单位：Rice University; Rice University; University System of Georgia; Georgia Institute of Technology; New Jersey Institute of Technology; Rice University; University of Houston System; University of Houston; University of Houston System; University of Houston; Rice University; Rice University; Agency for Science Technology & Research (A*STAR); A*STAR - Institute of High Performance Computing (IHPC); Nanyang Technological University; Rice University
  摘要：The growth and penetration of lithium dendrites through electrolytes and separators remain key challenges to realizing high-energy density lithium-metal batteries. Using mechanically strong electrolytes and separators has been considered a promising strategy based on the commonly believed softness of lithium. However, dendrite formation persists in stiff solid electrolytes, suggesting distinct mechanical behaviors. We measured the mechanical properties of individual lithium dendrites using an ...
• NASA administrator teases new science efforts AI翻译
  作者：Voosen, Paul
• ARPA-H bets big to foster drugs that thwart aging AI翻译
  作者：Leslie, Mitch
• Seal and sea lion brains have evolved to support volitional control of vocal behavior and learning AI翻译
  作者：Cook, Peter F.; Rouse, Andrew A.; Sawyer, Eva; Miller, Karla; Berns, Gregory
  作者单位：State University System of Florida; New College Florida; University of California System; University of California Santa Cruz; Vanderbilt University; University of Oxford; Emory University
  摘要：Seals and sea lions have highly developed volitional breathing control, to which the phocid seals add vocal production learning, including mimicry. In this work, using histology and ex vivo diffusion magnetic resonance imaging tractography, we provide evidence for a phylogenetic spectrum of accumulative neural adaptations supporting aspects of volitional vocal control across pinnipeds. Otariids and phocid seals, but not coyotes, have a direct connection between the vocal motor cortex and phona...
• The imminent collapse of the Great Salt Lake AI翻译
  作者：Kardon, Gabrielle
  作者单位：Utah System of Higher Education; University of Utah
• Cancer interception with KRAS inhibitors in preclinical models of pancreatic ductal adenocarcinoma AI翻译
  作者：Than, Minh T.; Dequiedt, Lucie; Sor, Rina; Nair, Shreya; Markosyan, Nune; Furth, Emma E.; Yang, Chenghua; Ray-Fofana, Courtney; Menard, Marie; Quintana, Elsa; Edwards, A. Cole; Hennessey, Connor J.; Good, Austin L.; Quinones, Liz; Hwang, Yunseo; Clendenin, Cynthia; Kiemen, Ashley L.; Vonderheide, Robert H.; Stanger, Ben Z.
  作者单位：University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; Johns Hopkins University; University of Pennsylvania; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine
  摘要：Transformation of pancreatic epithelial cells to malignant pancreatic ductal adenocarcinoma (PDAC) typically involves the progression of precancerous pancreatic intraepithelial neoplasia (PanINs) bearing oncogenic KRAS mutations. Here, we tested the impact of PDAC interception using either RAS(ON) multiselective or RAS(ON) G12D-selective pharmacological inhibitors [RAS(ON) inhibitors] in mouse models of PDAC. Treatment of PanIN-bearing mice with RAS(ON) inhibitors prompted regression of premal...
• Plan to break up iconic US climate lab moves ahead: Bidders have lined up to take over pieces of the National Center for Atmospheric Research AI翻译
  作者：Voosen, Paul