6790期

最新文章

• The fiscal impact of biodiversity loss and a pathway for conservation finance AI翻译
  作者：Nakhmurina, Anya; Manning, Dale T.; Fenichel, Eli P.
  作者单位：Yale University; Yale University; University of Tennessee System; University of Tennessee Knoxville
• My new apprentice AI翻译
  作者：Rosenfeld, Ariel
  作者单位：Bar Ilan University
• Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis AI翻译
  作者：Wan, Yinan; El Kholtei, Jakob; Jenie, Ignatius; Colomer-Rosell, Mariona; Liu, Jialin; Zhang, Qinghua; Acedo, Joaquin Navajas; Du, Lucia Y.; Codina-Tobias, Mireia; Wang, Mengfan; Zheng, Wei; Lin, Edward; Chuang, Tzy-Harn; Mayseless, Oded; Sawh, Ahilya; Mango, Susan E.; Yu, Guoqiang; Bintu, Bogdan; Schier, Alexander F.
  作者单位：University of Basel; University of California System; University of California San Diego; Tsinghua University; Virginia Polytechnic Institute & State University; University of Toronto
  摘要：Gene expression patterns underlie development, but their systematic detection in whole embryos has remained elusive. We introduce a whole-embryo imaging platform using multiplexed error-robust fluorescent in situ hybridization (weMERFISH). We quantified the expression of 495 genes in zebrafish embryos at subcellular resolution and generated an online atlas detailing the expression of 25,872 genes and accessibility of 294,954 chromatin regions during embryogenesis. Expression patterns often cor...
• Programmable genome editing in human cells using RNA-guided bridge recombinases AI翻译
  作者：Pelea, Oana; Talas, Andras; Carrera, Javier Fernandez; Mathis, Nicolas; van de Venn, Lilly; Yeh, Charles D.; Kulcsar, Peter I.; Marquart, Kim F.; Weber, Yanik; Gerecke, Saskia E.; Harvey-Seutcheu, Isabelle F.; Mailander, Dominic; Pfleiderer, Moritz M.; Chanez, Christelle; Corn, Jacob E.; Schwank, Gerald; Jinek, Martin
  作者单位：University of Zurich; University of Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich
  摘要：Site-specific insertion of gene-sized DNA fragments remains an unmet need in the field of genome editing. IS110-family serine recombinases have recently been shown to mediate programmable DNA recombination in bacteria by using a bispecific RNA guide (bridge RNA) that simultaneously recognizes target and donor sites. In this work, we have shown that the bridge recombinase ISCro4 is highly active in human cells and provided structural insights into its enhanced activity. Using plasmid- or all-RN...
• Ravens anticipate wolf kill sites across broad scales AI翻译
  作者：Loretto, Matthias-Claudio; Beck, Kristina B.; Smith, Douglas W.; Stahler, Daniel R.; Walker, Lauren E.; Wikelski, Martin; Mueller, Thomas; Safi, Kamran; Marzluff, John M.
  作者单位：University of Veterinary Medicine Vienna; Max Planck Society; Senckenberg Biodiversitat & Klima- Forschungszentrum (BiK-F); Leibniz Association; Senckenberg Gesellschaft fur Naturforschung (SGN); United States Department of the Interior; US National Park Service; University of Konstanz; Goethe University Frankfurt; University of Washington; University of Washington Seattle
  摘要：Scavengers generally rely on patchily distributed, unpredictable carrion. A long-standing hypothesis suggests scavenging ravens reliably locate such food by directly following large carnivores to their kills. However, by satellite tracking 69 ravens, 20 wolves, and 11 cougars in Yellowstone National Park, we found that following of predators over large distances rarely occurred. Instead, ravens routinely revisited sites where wolf kills were common-returning from distances of up to 155 kilomet...
• What's the catch of the day? AI翻译
  作者：Travis, Joseph; Reznick, David
  作者单位：State University System of Florida; Florida State University; University of California System; University of California Riverside
• Evolutionary adaptation to global change reduces sustainable fisheries yields AI翻译
  作者：Kozlowski, Jan; Marshall, Dustin J.; White, Craig R.
  作者单位：Jagiellonian University; Monash University
  摘要：Global warming is altering the fisheries that underpin food security, but projections of these impacts generally exclude evolutionary processes. We describe a model that forecasts how fish will adapt to future climates and the consequences of that evolution for fisheries yields. We predict that fish in warmer waters will grow faster but evolve earlier maturation, decreasing their maximum size. We predict that evolution ameliorates the impacts of climate change on fish fitness but exacerbates i...
• Releasing agriculture from the food security mandate AI翻译
  作者：Mueller, Christoph
  作者单位：Potsdam Institut fur Klimafolgenforschung
• Extending the reach of a classic oncogene: Exocytosis exposes Src at the outer surface of cancer cells, poised for therapeutic targeting AI翻译
  作者：Pfannenstein, Alexander; Meyer, Tobias
  作者单位：Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine
• Evolution to the rescue Recovery of wildflower populations from extreme drought reveals hidden evolutionary resilience AI翻译
  作者：Urban, Mark C.; Balstad, Laurinne J.
  作者单位：University of Connecticut; University of Connecticut; University of British Columbia