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作者：Zhong, Hai; Wang, Shiyu; Zhang, Qinghua; Liu, Zhuohui; Xie, Donggang; Lu, Jiali; Jin, Shifeng; Zhang, Shufang; Guo, Er-jia; He, Meng; Wang, Can; Gu, Lin; Yang, Guozhen; Jin, Kui-juan; Ge, Chen
作者单位：Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Physics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Tsinghua University; Tsinghua University
摘要：Ferroelectric charged domain walls (CDWs) with nanoscale thickness and bound charges are typically viewed as ultrathin, reconfigurable, and highly conductive two-dimensional components for domain wall nanoelectronics. Dimensional confinement of such polar topological structures has the potential to increase device density and unlock novel functionalities. We report 180 degrees head-to-head and tail-to-tail CDWs exhibiting one-dimensional (1D) characteristics. These 1D CDWs are confined within ...
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作者：Gauci, Vincent
作者单位：University of Birmingham; University of Birmingham; University of Birmingham
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作者：Piller, Charles
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作者：Ruan, Yiting; Dong, Shangzhi; Jiang, Suyu; Wang, Yisheng; Wu, Xiaotan; Zhuang, Yuxin; Wu, Wenjuan; East, Alison K.; Xu, Ping; Poole, Philip S.; Zhang, Yu; Murray, Jeremy D.
作者单位：Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS; University of Oxford; Shanghai Normal University
摘要：The specific partnership between legumes and rhizobia relies on a chemical dialogue. Plant flavonoids activate the bacterial transcription factor NodD, which triggers production of Nod factors that are recognized by the plant. Structural studies of the Pisum sativum (pea) symbiont Rhizobium leguminosarum NodD revealed two pockets that are essential for its activation by flavonoids. Comparative studies with NodD1 of Sinorhizobium medicae, the symbiont of Medicago truncatula, revealed that this ...
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作者：Sereno, Paul C.; Saitta, Evan T.; Vidal, Daniel; Myhrvold, Nathan; Ciudad Real, Maria; Baumgart, Stephanie L.; Bop, Lauren L.; Keillor, Tyler M.; Eriksen, Marcus; Derstler, Kraig
作者单位：University of Chicago; University of Chicago; Universidad Nacional de Educacion a Distancia (UNED); Intellectual Ventures; State University System of Florida; University of Florida
摘要：Two mummies of the end-Cretaceous duck-billed dinosaur Edmontosaurus annectens preserve a fleshy crest over the neck and trunk, an interdigitating spike row over the hips and tail, and hooves capping the toes of the hind feet. A battery of tests showed that all of the fossilized integument (skin, spike, and hoof) are preserved as a thin (less than 1 millimeter) clay template that formed on the surface of a buried carcass during decay before the loss of all soft tissues and organic compounds. U...
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作者：Uller, Tobias; Feiner, Nathalie; Sacchi, Roberto; Zuffi, Marco; Scali, Stefano; Pafilis, Panayiotis; Plavos, Konstantinos; Abalos, Javier; Andrade, Pedro; Aguilar, Prem; Salvi, Daniele; While, Geoffrey M.
作者单位：Lund University; Max Planck Society; University of Pavia; University of Pisa; National & Kapodistrian University of Athens; National & Kapodistrian University of Athens; University of Valencia; Universidade do Porto; Universidade do Porto; Universidade do Porto; University of L'Aquila; University of Tasmania
摘要：Genetically determined color morphs are found in many animals. Polymorphism can be maintained by social selection if competitive interactions allow each morph to increase in frequency when rare. This reliance on negative frequency-dependent selection should make color polymorphism vulnerable to the appearance of novel phenotypes that disrupt competitive interactions among morphs. We show that the origin and adaptive spread of a sexually selected syndrome in common wall lizards (Podarcis murali...
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作者：Rodriguez, Violeta J.
作者单位：University of Illinois System; University of Illinois Urbana-Champaign
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作者：Burke, Martin D.
作者单位：University of Illinois System; University of Illinois Urbana-Champaign
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作者：Huang, Kexin; Zhang, Serena; Wang, Hanchen; Qu, Yuanhao; Lu, Yingzhou; Li, Ryan; Roohani, Yusuf; Qiu, Lin; Cao, Shiyi; Li, Gavin; Zhang, Junze; Yin, Di; Wierenga, Rick; Kavi, Deniz; Liu, Sherry; She, Tianwei; Marwaha, Shruti; Carter, Jennefer N.; Zhou, Xin; Wheeler, Matthew T.; Bernstein, Jonathan A.; Wang, Mengdi; He, Peng; Zhou, Jingtian; Snyder, Michael P.; Cong, Le; Regev, Aviv; Leskovec, Jure
作者单位：Stanford University; Stanford Medicine; Stanford University; Stanford University; Stanford University; University of Washington; University of Washington Seattle; University of California System; University of California Berkeley; Stanford University; Stanford University; Princeton University; University of California System; University of California San Francisco
摘要：Biomedical research is increasingly constrained by repetitive, fragmented workflows that slow discovery. We introduce Biomni, a general-purpose biomedical artificial intelligence agent that autonomously executes diverse research tasks. To map the biomedical action space, Biomni's action-discovery agent mines tools, databases, and protocols from thousands of publications across 25 domains, building a unified agentic environment. Its general-purpose architecture integrates large language model r...
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作者：Beel, Andrew J.; Mattei, Pierre-Jean; Kornberg, Roger D.
作者单位：Stanford University
摘要：The formation of metaphase chromosomes requires the activity of condensins, DNA translocases that reduce chromosomal length through the process of loop extrusion. Reduction of length, however, does not account for the increase in density of chromatin in condensed states. Here, we show that eukaryotic chromosomes are ionic hydrogels and that the chromosomal material is a two-state system, with interconversion between condensed and decondensed states through a volume phase transition, analogous ...
