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作者：Raty, Jean -Yves; Bichara, Christophe; Schoen, Carl-Friedrich; Gatti, Carlo; Wuttig, Matthias
作者单位：University of Liege; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Physics (INP); Aix-Marseille Universite; RWTH Aachen University; Consiglio Nazionale delle Ricerche (CNR); Istituto di Scienze Tecnologie Chimiche Giulio Natta (SCITEC-CNR); Helmholtz Association; Research Center Julich
摘要：Glasses are commonly described as disordered counterparts of the corresponding crystals; both usually share the same short -range order, but glasses lack long -range order. Here, a quantification of chemical bonding in a series of glasses and their corresponding crystals is performed, employing two quantum- chemical bonding descriptors, the number of electrons transferred and shared between adjacent atoms. For popular glasses like SiO2, GeSe2, and GeSe, the quantum- chemical bonding descriptor...
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作者：Jin, Meichi; Ding, Jingyi; Zhou, Yu; Chen, Jiazhao; Wang, Yi; Li, Zida
作者单位：Shenzhen University; Shenzhen University; Shenzhen University
摘要：Multiplex, digital nucleic acid detections have important biomedical applications, but probes, making the detection complicated and costly. Here, we present the StratoLAMP for label- free, multiplex digital loop- mediated isothermal amplification based on visual stratification of the precipitate byproduct. The StratoLAMP designates two sets of primers with different concentrations to achieve different precipitate yields when amplifying different nucleic acid targets. In the detection, deep lea...
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作者：Deng, Xingguang; He, Ying; Tang, Xiaoya; Liu, Xianghong; Lee, Yuh- Ru Julie; Liu, Bo; Lin, Honghui
作者单位：Sichuan University; University of California System; University of California Davis
摘要：The kinetochore scaffold 1 (KNL1) protein recruits spindle assembly checkpoint (SAC) proteins to ensure accurate chromosome segregation during mitosis. Despite such a conserved function among eukaryotic organisms, its molecular architectures have rapidly evolved so that the functional mode of plant KNL1 is largely unknown. To understand how SAC signaling is regulated at kinetochores, we characterized the function of the KNL1 gene in Arabidopsis thaliana. The KNL1 protein was detected at kineto...
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作者：Gao, Forson; Ye, Fuzhou; Zhang, Bowen; Cronin, Nora; Buck, Martin; Zhang, Xiaodong
作者单位：Imperial College London; Francis Crick Institute; Imperial College London; Francis Crick Institute
摘要：Gene transcription is a fundamental cellular process carried out by RNA polymerase (RNAP). Transcription initiation is highly regulated, and in bacteria, transcription initiation is mediated by sigma (sigma) factors. sigma recruits RNAP to the promoter DNA region, located upstream of the transcription start site (TSS) and facilitates open complex formation, where double-stranded DNA is opened up into a transcription bubble and template strand DNA is positioned inside RNAP for initial RNA synth...
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作者：Mills, Daniel B.; Simister, Rachel L.; Sehein, Taylor R.; Hallam, Steven J.; Sperling, Erik A.; Crowe, Sean A.
作者单位：University of Munich; Stanford University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; University of British Columbia; Smith College; University of British Columbia; University of British Columbia; University of British Columbia; University of British Columbia; University of British Columbia; University of British Columbia
摘要：Eukaryotes originated prior to the establishment of modern marine oxygen (O2) levels. According to the body fossil and lipid biomarker records, modern (crown) microbial eukaryote lineages began diversifying in the ocean no later than -800 Ma. While it has long been predicted that increasing atmospheric O2 levels facilitated the early diversification of microbial eukaryotes, the O2 levels needed to permit this diversifi-cation remain unconstrained. Using time- resolved geochemical parameter and...
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作者：Zhao, Song-Chuan; Zhang, Hao-Jie; Li, Yudong
作者单位：Xi'an Jiaotong University
摘要：When making contact with an undercooled target, a drop freezes. The colder the target is, the more rapid the freezing is supposed to be. In this research, we explore the impact of droplets on cold granular material. As the undercooling degree increases, the bulk freezing of the droplet is delayed by at least an order of magnitude. The postponement of the overall solidification is accompanied by substantial changes in dynamics, including the spreading-retraction process, satellite drop generati...
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作者：[Anonymous]
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作者：Cui, Mengying; Yamano, Koji; Yamamoto, Kenichi; Yamamoto-Imoto, Hitomi; Minami, Satoshi; Yamamoto, Takeshi; Matsui, Sho; Kaminishi, Tatsuya; Shima, Takayuki; Ogura, Monami; Tsuchiya, Megumi; Nishino, Kohei; Layden, Brian T.; Kato, Hisakazu; Ogawa, Hidesato; Oki, Shinya; Okada, Yukinori; Isaka, Yoshitaka; Kosako, Hidetaka; Matsuda, Noriyuki; Yoshimori, Tamotsu; Nakamura, Shuhei
作者单位：University of Osaka; Tokyo Metropolitan Institute of Medical Science; Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU); University of Osaka; University of Osaka; University of Osaka; University of Osaka; Nara Medical University; University of Osaka; University of Osaka; Tokushima University; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; US Department of Veterans Affairs; Veterans Health Administration (VHA); Jesse Brown VA Medical Center; University of Osaka; Kyoto University; University of Osaka
摘要：Mitochondrial and lysosomal functions are intimately linked and are critical for cellular homeostasis, as evidenced by the fact that cellular senescence, aging, and multiple prominent diseases are associated with concomitant dysfunction of both organelles. However, it is not well understood how the two important organelles are regulated. Transcription factor EB (TFEB) is the master regulator of lysosomal function and is also implicated in regulating mitochondrial function; however, the mechani...
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作者：Fu, Yong; Wang, Bincheng; Wang, Kan; Tang, Xiangyu; Li, Baochang; Yin, Zhiming; Han, Jiaxin; Lin, C. D.; Jin, Cheng
作者单位：Nanjing University of Science & Technology; Kansas State University; Nanjing University of Science & Technology
摘要：High-harmonic generation from a gas target exhibits sharp spectral features and rapid phase variation near the Cooper minimum. By applying spectral filtering, shaped isolated attosecond pulses can be generated where the pulse is split into two in the time domain. Using such shaped extreme-ultraviolet (XUV) pulses, we theoretically study attosecond transient absorption (ATA) spectra of helium 2s2p autoionizing state which is resonantly coupled to the 2s2 dark state by a time-delayed infrared la...
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作者：Tong, Yuquan; Zhang, Peiyuan; Yang, Xueyi; Liu, Xiaohui; Zhang, Jie; Grudniewska, Magda; Jung, Ikrak; Abegg, Daniel; Liu, Jun; Childs-Disney, Jessica L.; Gibaut, Quentin M. R.; Haniff, Hafeez S.; Adibekian, Alexander; Mouradian, M. Maral; Disney, Matthew D.
作者单位：State University System of Florida; University of Florida; Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology; Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences; Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences
摘要：alpha-Synuclein is an important drug target for the treatment of Parkinson's disease (PD), but it is an intrinsically disordered protein lacking typical small-molecule binding pockets. In contrast, the encoding SNCA mRNA has regions of ordered structure in its 5 ' untranslated region (UTR). Here, we present an integrated approach to identify small molecules that bind this structured region and inhibit alpha-synuclein translation. A drug-like, RNA-focused compound collection was studied for bin...
