2期

最新文章

• Magnon- mediated qubit coupling determined via dissipation measurements AI翻译
  作者：Fukami, Masaya; Marcks, Jonathan C.; Candido, Denis R.; Weiss, Leah R.; Soloway, Benjamin; Sullivan, Sean E.; Delegan, Nazar; Heremans, F. Joseph; Flatte, Michael E.; Awschalom, David D.
  作者单位：University of Chicago; United States Department of Energy (DOE); Argonne National Laboratory; United States Department of Energy (DOE); Argonne National Laboratory; University of Iowa; Tohoku University; Eindhoven University of Technology
  摘要：Controlled interaction between localized and delocalized solid -state spin systems offers a compelling platform for on -chip quantum information processing with quantum spintronics. Hybrid quantum systems (HQSs) of localized nitrogen- vacancy (NV) centers in diamond and delocalized magnon modes in ferrimagnets-systems with naturally commensurate energies-have recently attracted significant attention, especially for interconnecting isolated spin qubits at length- scales far beyond those set by ...
• Gp130-HIF1α axis-induced vascular damage is prevented by the short- term inhibition of IL-6 receptor signaling AI翻译
  作者：Kang, Sujin; Onishi, Shinya; Ling, Zhenzhen; Inoue, Hitomi; Zhang, Yingying; Chang, Hao; Zhao, Hui; Wang, Tong; Okuzaki, Daisuke; Matsuura, Hiroshi; Takamatsu, Hyota; Oda, Jun; Kishimoto, Tadamitsu
  作者单位：University of Osaka; University of Osaka; University of Osaka; University of Osaka; University of Osaka
  摘要：Protection against endothelial damage is recognized as a frontline approach to preventing the progression of cytokine release syndrome (CRS). Accumulating evidence has demonstrated that interleukin-6 (IL 6) promotes vascular endothelial damage during CRS, although the molecular mechanisms remain to be fully elucidated. Targeting IL 6 receptor signaling delays CRS progression; however, current options are limited by persistent inhibition of the immune system. Here, we show that endothelial IL 6...
• Polyphosphate kinase-1 regulates bacterial and host metabolic pathways involved in pathogenesis of Mycobacterium tuberculosis AI翻译
  作者：Chugh, Saurabh; Tiwari, Prabhakar; Suri, Charu; Gupta, Sonu Kumar; Singh, Padam; Bouzeyen, Rania; Kidwai, Saqib; Srivastava, Mitul; Rameshwaram, Nagender Rao; Kumar, Yashwant; Asthana, Shailendra; Singh, Ramandeep
  作者单位：Department of Biotechnology (DBT) India; Translational Health Science & Technology Institute (THSTI); Pasteur Network; Universite de Tunis-El-Manar; Institut Pasteur Tunis
  摘要：Inorganic polyphosphate (polyP) is primarily synthesized by Polyphosphate Kinase-1 (PPK-1) and regulates numerous cellular processes, including energy metabolism, stress adaptation, drug tolerance, and microbial pathogenesis. Here, we report that polyP interacts with acyl CoA carboxylases, enzymes involved in lipid biosynthesis in Mycobacterium tuberculosis. We show that deletion of ppk-1 in M. tuberculosis results in transcriptional and metabolic reprogramming. In comparison to the parental s...
• Anomalously enhanced ion transport and uptake in functionalized angstrom- scale two- dimensional channels AI翻译
  作者：Wang, Mingzhan; Sadhukhan, Tumpa; Lewis, Nicholas H. C.; Wang, Maoyu; He, Xiang; Yan, Gangbin; Ying, Dongchen; Hoenig, Eli; Han, Yu; Peng, Guiming; Lee, One-Sun; Shi, Fengyuan; Tiede, David M.; Zhou, Hua; Tokmakoff, Andrei; Schatz, George C.; Liu, Chong
  作者单位：University of Chicago; Northwestern University; SRM Institute of Science & Technology Chennai; University of Chicago; University of Chicago; United States Department of Energy (DOE); Argonne National Laboratory; United States Department of Energy (DOE); Argonne National Laboratory; United States Department of Energy (DOE); Argonne National Laboratory; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; Florida Institute of Technology; Jiangxi Normal University
  摘要：Emulating angstrom -scale dynamics of the highly selective biological ion channels is a challenging task. Recent work on angstrom -scale artificial channels has expanded our understanding of ion transport and uptake mechanisms under confinement. However, the role of chemical environment in such channels is still not well understood. Here, we report the anomalously enhanced transport and uptake of ions under confined MoS2-based channels that are -five angstroms in size. The ion uptake preferenc...
• All SNAP25 molecules in the vesicle-plasma membrane contact zone change conformation during vesicle priming AI翻译
  作者：Zhao, Ying; Fang, Qinghua; Sharma, Satyan; Jakhanwal, Shrutee; Jahn, Reinhard; Lindau, Manfred
  作者单位：Max Planck Society; Uppsala University; Max Planck Society; University of Miami
  摘要：In neuronal cell types, vesicular exocytosis is governed by the SNARE (soluble NSF attachment receptor) complex consisting of synaptobrevin2, SNAP25, and syntaxin1. These proteins are required for vesicle priming and fusion. We generated an improved SNAP25-based SNARE COmplex Reporter (SCORE2) incorporating mCeruelan3 and Venus and overexpressed it in SNAP25 knockout embryonic mouse chromaffin cells. This construct rescues vesicle fusion with properties indistinguishable from fusion in wild-ty...
• An even drier future for the arid lands AI翻译
  作者：Allan, Richard P.; Douville, Herve
  作者单位：University of Reading; UK Research & Innovation (UKRI); Natural Environment Research Council (NERC); NERC National Centre for Earth Observation; University of Reading; Meteo France; Centre National de la Recherche Scientifique (CNRS); Universite de Toulouse
• Concurrent warming and browning eliminate cold- water fish habitat in many temperate lakes AI翻译
  作者：Jane, Stephen F.; Detmer, Thomas M.; Larrick, Siena L.; Rose, Kevin C.; Randall, Eileen A.; Jirka, Kurt J.; McIntyre, Peter B.
  作者单位：Cornell University; Cornell University; Rensselaer Polytechnic Institute; University of Notre Dame
  摘要：Cold- water species in temperate lakes face two simultaneous climate- driven ecosystem changes: warming and browning of their waters. Browning refers to reduced transparency arising from increased dissolved organic carbon (DOC), which absorbs solar energy near the surface. It is unclear whether the net effect is mitigation or amplification of climate warming impacts on suitable oxythermal habitat ( 20 degrees C, 5 mgO/L) for cold- loving species because browning expands the vertical distributi...
• Author affiliations: a; bc; d; ef g h; i jnd k AI翻译
  作者：Ganier, Clarisse; Mazin, Pavel; Herrera-Oropeza, Gabriel; Du-Harpur, Xinyi; Blakeley, Matthew; Gabriel, Jeyrroy; Predeus, Alexander, V; Cakir, Batuhan; Prete, Martin; Harun, Nasrat; Darrigrand, Jean-Francois; Haiser, Alexander; Wyles, Saranya; Shaw, Tanya; Teichmann, Sarah A.; Haniffa, Muzlifah; Watt, Fiona M.; Lynch, Magnus D.
  作者单位：Guy's & St Thomas' NHS Foundation Trust; University of London; King's College London; University of London; King's College London; Francis Crick Institute; Mayo Clinic; University of London; King's College London; University of Cambridge; Newcastle University - UK; Newcastle Upon Tyne Hospitals NHS Foundation Trust; European Molecular Biology Laboratory (EMBL); University of London; King's College London; Guy's & St Thomas' NHS Foundation Trust
  摘要：Our understanding of how human skin cells differ according to anatomical site and tumour formation is limited. To address this, we have created a multiscale spatial atlas of healthy skin and basal cell carcinoma (BCC), incorporating in vivo optical coherence tomography, single cell RNA sequencing, spatial global transcriptional profiling, and in situ sequencing. Computational spatial deconvolution and projection revealed the localisation of distinct cell populations to specific tissue contexts...
• Self- assembled active actomyosin gels spontaneously curve and wrinkle similar to biological cells and tissues AI翻译
  作者：Livne, Gefen; Gat, Shachar; Armon, Shahaf; Groswasser, Anne Bernheim -
  作者单位：Ben-Gurion University of the Negev; Weizmann Institute of Science
  摘要：Living systems adopt a diversity of curved and highly dynamic shapes. These diverse morphologies appear on many length scales, from cells to tissues and organismal scales. The common driving force for these dynamic shape changes are contractile stresses gen-erated by myosin motors in the cell cytoskeleton, that converts chemical energy into mechanical work. A good understanding of how contractile stresses in the cytoskeleton arise into different three- dimensional (3D) shapes and what are the ...
• White matter plasticity during second language learning within and across hemispheres AI翻译
  作者：Wei, Xuehu; Gunter, Thomas C.; Adamson, Helyne; Schwendemann, Matthias; Friederici, Angela D.; Goucha, Tomas; Anwander, Alfred
  作者单位：Max Planck Society
  摘要：Adult second language (L2) learning is a challenging enterprise inducing neuroplastic changes in the human brain. However, it remains unclear how the structural language connectome and its subnetworks change during adult L2 learning. The current study investigated longitudinal changes in white matter (WM) language networks in each hemisphere, as well as their interconnection, in a large group of Arabic- speaking adults who learned German intensively for 6 mo. We found a significant increase in...