2期

最新文章

• Development of prediction models to identify hotspots of schistosomiasis in endemic regions to guide mass drug administration AI翻译
  作者：Singer, Benjamin J.; Coulibaly, Jean T.; Park, Hailey J.; Andrews, Jason R.; Bogoch, Isaac I.; Lo, Nathan C.
  作者单位：Stanford University; Universite Felix Houphouet-Boigny; Centre Suisse de Recherches Scientifiques en Cote d'Ivoire (CSRS); University of Basel; Swiss Tropical & Public Health Institute; University of Basel; University of Toronto
  摘要：Schistosomiasis is a neglected tropical disease affecting over 150 million people. Hotspots of Schistosoma transmission-communities where infection prevalence does not decline adequately with mass drug administration-present a key challenge in eliminating schistosomiasis. Current approaches to identify hotspots require evaluation 2-5 y after a baseline survey and subsequent mass drug administration. Here, we develop statistical models to predict hotspots at baseline prior to treatment comparin...
• Self- organized BMP signaling dynamics underlie the development and evolution of digit segmentation patterns in birds and mammals AI翻译
  作者：Grall, Emmanuelle; Feregrino, Christian; Fischer, Sabrina; De Courten, Aline; Sacher, Fabio; Hiscock, Tom W.; Tschopp, Patrick
  作者单位：University of Basel; University of Aberdeen; Helmholtz Association; Max Delbruck Center for Molecular Medicine
  摘要：Repeating patterns of synovial joints are a highly conserved feature of articulated digits, with variations in joint number and location resulting in diverse digit morphologies and limb functions across the tetrapod clade. During the development of the amniote limb, joints form iteratively within the growing digit ray, as a population of distal progenitors alternately specifies joint and phalanx cell fates to segment the digit into distinct elements. While numerous molecular pathways have been...
• Mechanistic basis for potassium efflux-driven activation of the human NLRP1 inflammasome AI翻译
  作者：Rozario, Pritisha; Pinilla, Miriam; Gorse, Leana; Vind, Anna Constance; Robinson, Kim S.; Toh, Gee Ann; Firdaus, Muhammad Jasrie; Martinez, Jose Francisco; Kerk, Swat Kim; Lin, Zhewang; Chambers, John C.; Bekker-Jensen, Simon; Meunier, Etienne; Zhong, Franklin
  作者单位：Nanyang Technological University; Centre National de la Recherche Scientifique (CNRS); Universite de Toulouse; University of Copenhagen; University of Copenhagen; Agency for Science Technology & Research (A*STAR); Agency for Science Technology & Research (A*STAR); Skin Research Institute of Singapore (SRIS); Nanyang Technological University; National University of Singapore; University of York - UK
  摘要：Nigericin, an ionophore derived from Streptomyces hygroscopicus, is arguably the most commonly used tool compound to study the NLRP3 inflammasome. Recent findings, however, showed that nigericin also activates the NLRP1 inflammasome in human keratinocytes. In this study, we resolve the mechanistic basis of nigericin- driven NLRP1 inflammasome activation. In multiple nonhematopoietic cell types, nigericin rapidly and specifically inhibits the elongation stage of the ribosome cycle by depleting ...
• Deregulation of the Hippo pathway in soft- tissue sarcoma promotes FOXM1 expression and tumorigenesis(vol 112, pg E3402, 2015) AI翻译
  作者：Eisinger-Mathason, T. S. Karin; Mucaj, Vera; Biju, Kevin M.; Nakazawa, Michael S.; Gohil, Mercy; Cash, Timothy P.; Yoon, Sam S.; Skuli, Nicolas; Park, Kyung Min; Gerecht, Sharon; Simon, M. Celeste
• Exploring in-plane interactions beside an adsorbed molecule with lateral force microscopy AI翻译
  作者：Nam, Shinjae; Riegel, Elisabeth; Hoermann, Lukas; Hofmann, Oliver T.; Gretz, Oliver; Weymouth, Alfred J.; Giessibl, Franz J.
  作者单位：University of Regensburg; Graz University of Technology
  摘要：Atomic force microscopy with a CO- functionalized tip can be used to directly image the internal structure of a planar molecule and to characterize chemical bonds. However, hydrogen atoms usually cannot be directly observed due to their small size. At the same time, these atoms are highly important, since they can direct on- surface chemical reactions. Measuring in-plane interactions at the sides of PTCDA (3,4,9,10- perylenetetracarboxylic dianhydride) molecules with lateral force microscopy a...
• Longevity, demographic characteristics, and socio- economic status are linked to triiodothyronine levels in the general population AI翻译
  作者：Lawton, Ralph I.; Sabatini, Bernardo L.; Hochbaum, Daniel R.
  作者单位：Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Howard Hughes Medical Institute
  摘要：The hypothalamic-pituitary-thyroid (HPT) axis is fundamental to human biology, exerting central control over energy expenditure and body temperature. However, the consequences of normal physiologic HPT-axis variation in populations without diagnosed thyroid disease are poorly understood. Using nationally representative data from the 2007 to 2012 National Health and Nutrition Examination Survey, we explore relationships with demographic characteristics, longevity, and socio- economic factors. W...
• Oxazolone mediated peptide chain extension and homochirality in aqueous microdroplets AI翻译
  作者：Qiu, Lingqi; Cooks, Graham
  作者单位：Purdue University System; Purdue University
  摘要：Peptide formation from amino acids is thermodynamically unfavorable but a recent study provided evidence that the reaction occurs at the air/solution interfaces of aqueous microdroplets. Here, we show that i) the suggested amino acid complex in microdrop-lets undergoes dehydration to form oxazolone; ii) addition of water to oxazolone forms the dipeptide; and iii) reaction of oxazolone with other amino acids forms tripeptides. Furthermore, the chirality of the reacting amino acids is preserved ...
• Lipid shape and packing are key for optimal design of pH-sensitive mRNA lipid nanoparticles AI翻译
  作者：Tesei, Giulio; Hsiao, Ya -Wen; Dabkowsk, Aleksandra; Groenberg, Gunnar; Arteta, Marianna Yanez; Ulkoski, David; Bray, David J.; Trulsson, Martin; Ulandef, Johan; Lund, Mikael; Lindfors, Lennart
  作者单位：University of Copenhagen; University of Copenhagen; Lund University; STFC Daresbury Laboratory; UK Research & Innovation (UKRI); Science & Technology Facilities Council (STFC); AstraZeneca; AstraZeneca; AstraZeneca
  摘要：The ionizable-lipid component of RNA-containing nanoparticles controls the pH-dependent behavior necessary for an efficient delivery of the cargo-the so-called endosomal escape. However, it is still an empirical exercise to identify optimally performing lipids. Here, we study two well-known ionizable lipids, DLin-MC3-DMA and DLin-DMA using a combination of experiments, multiscale computer simulations, and electrostatic theory. All -atom molecular dynamics simulations, and experimentally measur...
• A bacterial pigment provides cross- species protection from H2O2-and neutrophil- mediated killing AI翻译
  作者：Liu, Yiwei; McQuillen, Eleanor A.; Rana, Pranav S. J. B.; Gloag, Erin S.; Parsek, Matthew R.; Wozniak, Daniel J.
  作者单位：University System of Ohio; Ohio State University; University System of Ohio; Ohio State University; University System of Ohio; Ohio State University; Virginia Polytechnic Institute & State University; University of Washington; University of Washington Seattle
  摘要：Bacterial infections are often polymicrobial. Pseudomonas aeruginosa and Staphylococcus aureus cause chronic co- infections, which are more problematic than mono- species infections. Understanding the mechanisms of their interactions is crucial for treating co- infections. Staphyloxanthin (STX), a yellow pigment synthesized by the S. aureus crt operon, promotes S. aureus resistance to oxidative stress and neutrophil- mediated killing. We found that STX production by S. aureus, either as surfac...
• Microscopic interactions control a structural transition in active mixtures of microtubules and molecular motors AI翻译
  作者：Najma, Bibi; Wei, Wei- Shao; Baskaran, Aparna; Foster, Peter J.; Duclos, Guillaume
  作者单位：Brandeis University; University of Southern California
  摘要：Microtubules and molecular motors are essential components of the cellular cytoskeleton, driving fundamental processes in vivo, including chromosome segregation and cargo transport. When reconstituted in vitro, these cytoskeletal proteins serve as energy- consuming building blocks to study the self- organization of active matter. Cytoskeletal active gels display rich emergent dynamics, including extensile flows, locally contractile asters, and bulk contraction. However, it is unclear how the p...