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作者：Chuaychob, Surachada; Lyu, Ruyin; Tanaka, Miwa; Haginiwa, Ayumi; Kitada, Atsuya; Nakamura, Takuro; Yokokawa, Ryuji
作者单位：Kyoto University; Japanese Foundation for Cancer Research; Tokyo Medical University
摘要：Alveolar soft - part sarcoma (ASPS) is a slow- growing soft tissue sarcoma with high mortality rates that affects adolescents and young adults. ASPS resists conventional chemotherapy; thus, decades of research have elucidated pathogenic mechanisms driving the disease, particularly its angiogenic capacities. Integrated blood vessels that are rich in pericytes (PCs) and metastatic potential are distinctive of ASPS. To mimic ASPS angiogenic microenvironment, a microfluidic coculture vasculature c...
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作者：Yang, Jonathan Lee; Yamada-Hunter, Sean A.; Labanieh, Louai; Sotillo, Elena; Cheah, Joleen S.; Roberts, David S.; Mackall, Crystal L.; Bertozzi, Carolyn R.; Ting, Alice Y.
作者单位：Stanford University; Stanford University; Stanford University; Stanford Cancer Institute; Stanford University; Stanford University; Stanford University; Stanford University; Howard Hughes Medical Institute; Stanford University; Stanford University; Chan Zuckerberg Initiative (CZI)
摘要：Lysosome- targeting chimeras (LYTACs) are a promising therapeutic modality to drive the degradation of extracellular proteins. However, early versions of LYTAC contain synthetic glycopeptides that cannot be genetically encoded. Here, we present our designs for a fully genetically encodable LYTAC (GELYTAC), making our tool compatible with integration into therapeutic cells for targeted delivery at diseased sites. To achieve this, we replaced the glycopeptide portion of LYTACs with the protein i...
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作者：Crapart, Cecile C.; Scott, Zubenelgenubi C.; Konno, Tasuku; Sharma, Aman; Parutto, Pierre; Bailey, David M. D.; Westrate, Laura M.; Avezov, Edward; Koslover, Elena F.
作者单位：University of Cambridge; University of Cambridge; University of California System; University of California San Diego; Calvin University
摘要：The endoplasmic reticulum (ER) forms an interconnected network of tubules stretching throughout the cell. Understanding how ER functionality relies on its structural organization is crucial for elucidating cellular vulnerability to ER perturbations, which have been implicated in several neuronal pathologies. One of the key functions of the ER is enabling Ca2+ signaling by storing large quantities of this ion and releasing it into the cytoplasm in a spatiotemporally controlled manner. Through a...
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作者：Gao, Rui; Xu, Xinxin; Kumar, Prashant; Liu, Ye; Zhang, Hongyu; Guo, Xiao; Sun, Maozhong; Colombari, Felippe Mariano; Moura, Andre F. de; Hao, Changlong; Ma, Jessica; Emre, Emine Sumeyra Turali; Cha, Minjeong; Xu, Liguang; Kuang, Hua; Kotov, Nicholas A.; Xu, Chuanlai
作者单位：Jiangnan University; Jiangnan University; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Institute of Medical Biology - CAMS; Universidade Federal de Sao Carlos; University of Michigan System; University of Michigan
摘要：The incessant mutations of viruses, variable immune responses, and likely emergence of new viral threats necessitate multiple approaches to novel antiviral therapeutics. Furthermore, the new antiviral agents should have broad- spectrum activity and be environmentally stable. Here, we show that biocompatible tapered CuS nanoparticles (NPs) efficiently agglutinate coronaviruses with binding affinity dependent on the chirality of surface ligands and particle shape. L- penicillamine- stabilized NP...
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作者：Michl, Johanna; White, Bobby; Monterisi, Stefania; Bodmer, Walter F.; Swietach, Pawel
作者单位：University of Oxford; University of Oxford
摘要：Elevated cancer metabolism releases lactic acid and CO2 into the under- perfused tumor microenvironment, resulting in extracellular acidosis. The surviving cancer cells must adapt to this selection pressure; thus, targeting tumor acidosis is a rational therapeutic strategy to manage tumor growth. However, none of the major approved treatments are based explicitly on disrupting acid handling, signaling, or adaptations, possibly because the distinction between acid- sensitive and acid- resistant...
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作者：Fineberga, Adam; Takagi, Yasuharu; Thirumurugan, Kavitha; Andrecka, Joanna; Billingtonc, Neil; Young, Gavin; Cole, Daniel; Burgess, Stan A.; Curd, Alistair P.; Hammer, John A.; Sellers, James R.; Kukura, Philipp; Knight, Peter J.
作者单位：Vellore Institute of Technology (VIT); VIT Vellore; Human Technopole; West Virginia University; University of Oxford; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI); National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI); University of Leeds; University of Leeds; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI); University of Oxford
摘要：Molecular motors employ chemical energy to generate unidirectional mechanical output against a track while navigating a chaotic cellular environment, potential disorder on the track, and against Brownian motion. Nevertheless, decades of nanometer -precise optical studies suggest that myosin -5a, one of the prototypical molecular motors, takes uniform steps spanning 13 subunits (36 nm) along its F-actin track. Here, we use high -resolution interferometric scattering microscopy to reveal that my...
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作者：Basile, Samantha; Avery, Christopher W.; Grade, Aaron; Crimmins, Allison R.
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作者：Eller, Christina Ciocca
作者单位：Harvard University
摘要：It is common for social scientists to discuss the implications of our research for policy. However, what actions can we take to inform policy in more immediate and impactful ways, regardless of our existing institutional affiliations or personal connections? Focusing on federal policy, I suggest that the answer requires understanding a basic coordination problem. On the government side, the Foundations of Evidence- based Policymaking Act (2018) requires that large federal agencies pose, commun...
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作者：Sheinman, Michael; Arndt, Peter F.; Massip, Florian
作者单位：Max Planck Society; Universite PSL; MINES ParisTech; UNICANCER; Universite PSL; Institut Curie; Universite PSL; UNICANCER; Institut Curie; Institut National de la Sante et de la Recherche Medicale (Inserm)
摘要：The chronology and phylogeny of bacterial evolution are difficult to reconstruct due to a scarce fossil record. The analysis of bacterial genomes remains challenging because of large sequence divergence, the plasticity of bacterial genomes due to frequent gene loss, horizontal gene transfer, and differences in selective pressure from one locus to another. Therefore, taking advantage of the rich and rapidly accumulating genomic data requires accurate modeling of genome evolution. An important t...
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作者：Wang, Dongfang; Tang, Muya; Zhang, Peidong; Yang, Kailin; Huang, Liang; Wu, Mengrui; Shen, Qiuhong; Yue, Jing; Wang, Wei; Gong, Yanqiu; Warner, Margaret; Dai, Lunzhi; He, Haihuai; Yang, Zhengnan; Gustafsson, Jan-Ake; Zhou, Shengtao
作者单位：Sichuan University; Sichuan University; Cleveland Clinic Foundation; Sichuan University; Sichuan University; University of Houston System; University of Houston; Sichuan University; Karolinska Institutet
摘要：Triple- negative breast cancer (TNBC) is a subtype of breast cancer with aggressive behavior and poor prognosis. Current therapeutic options available for TNBC patients are primarily chemotherapy. With our evolving understanding of this disease, novel targeted therapies, including poly ADP- ribose polymerase (PARP) inhibitors, antibody-drug conjugates, and immune- checkpoint inhibitors, have been developed for clinical use. Previous reports have demonstrated the essential role of estrogen rece...
