13期

最新文章

• Reply to Francis: Replicability, false alarms, and walking through doorways AI翻译
  作者：Ongchoco, Joan Danielle K.; Walter-Terrill, Robert; Scholl, Brian J.
  作者单位：Yale University
• Uncommon and nonpartisan: Antidemocratic attitudes in the American public AI翻译
  作者：Holliday, Derek E.; Iyengar, Shanto; Lelkes, Yphtach; Westwood, Sean J.
  作者单位：Stanford University; University of Pennsylvania; Dartmouth College
  摘要：Democratic regimes flourish only when there is broad acceptance of an extensive set of norms and values. In the United States, fundamental democratic norms have recently come under threat from prominent Republican officials. We investigate whether this antidemocratic posture has spread from the elite level to rank -and -file partisans. Exploiting data from a massive repeated cross-sectional and panel survey (n = 45,095 and 5,231 respectively), we find that overwhelming majorities of the public...
• Vulnerability to APOBEC3G linked to the pathogenicity of deltaretroviruses AI翻译
  作者：Shichijo, Takafumi; Yasunaga, Jun-ichirou; Sato, Kei; Nosaka, Kisato; Toyoda, Kosuke; Watanabe, Miho; Zhang, Wenyi; Koyanagi, Yoshio; Murphy, Edward L.; Bruhn, Roberta L.; Koh, Ki-Ryang; Akari, Hirofumi; Ikeda, Terumasa; Harris, Reuben S.; Green, Patrick L.; Matsuoka, Masao
  作者单位：Kumamoto University; Kyoto University; University of Tokyo; Japan Science & Technology Agency (JST); Kyoto University; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Vitalant; Vitalant Research Institute; The West Japan Railway Company; Kyoto University; Kumamoto University; University of Texas System; University of Texas at San Antonio; Howard Hughes Medical Institute; University of Texas System; University of Texas at San Antonio; University System of Ohio; Ohio State University; University System of Ohio; Ohio State University
  摘要：Human retroviruses are derived from simian ones through cross-species transmission. These retroviruses are associated with little pathogenicity in their natural hosts, but in humans, HIV causes AIDS, and human T-cell leukemia virus type 1 (HTLV-1) induces adult T-cell leukemia-lymphoma (ATL). We analyzed the proviral sequences of HTLV-1, HTLV-2, and simian T-cell leukemia virus type 1 (STLV-1) from Japanese macaques (Macaca fuscata) and found that APOBEC3G (A3G) frequently generates G - to - A...
• HDX-MS finds that partial unfolding with sequential domain activation controls condensation of a cellular stress marker AI翻译
  作者：Chen, Ruofan; Glauninger, Hendrik; Kahan, Darren N.; Shangguan, Julia; Sachleben, Joseph R.; Riback, Joshua A.; Drummond, D. Allan; Sosnick, Tobin R.
  作者单位：Baylor College of Medicine; University of Chicago; University of Chicago; University of Chicago; University of Chicago; University of Chicago
  摘要：Eukaryotic cells form condensates to sense and adapt to their environment [S. F. Banani, H. O. Lee, A. A. Hyman, M. K. Rosen, Nat. Rev. Mol. Cell Biol. 18, 285-298 (2017), H. Yoo, C. Triandafillou, D. A. Drummond, J. Biol. Chem. 294, 7151-7159 (2019)]. Poly(A)- binding protein (Pab1), a canonical stress granule marker, condenses upon heat shock or starvation, promoting adaptation [J. A. Riback et al., Cell 168, 1028-1040. e19 (2017)]. The molecular basis of condensation has remained elusive du...
• The visual effect of wind turbines on property values is small and diminishing in space and time AI翻译
  作者：Guo, Wei; Wenz, Leonie; Auffhammer, Maximilian
  作者单位：Centro Euro-Mediterraneo sui Cambiamenti Climatici (CMCC); Potsdam Institut fur Klimafolgenforschung; University of California System; University of California Berkeley; National Bureau of Economic Research
  摘要：Renewable power generation is the key to decarbonizing the electricity system. Wind power is the fastest -growing renewable source of electricity in the United States. However, expanding wind capacity often faces local opposition, partly due to a perceived visual disamenity from large wind turbines. Here, we provide a US -wide assessment of the externality costs of wind power generation through the visibility impact on property values. To this end, we create a database on wind turbine visibili...
• Variable aging and storage of dissolved black carbon in the ocean AI翻译
  作者：Coppola, Alysha I.; Druffel, Ellen R. M.; Broek, Taylor A.; Haghipour, Negar; Eglinton, Timothy I.; Mccarthy, Matthew; Walker, Brett D.
  作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; University of California System; University of California Irvine; Woods Hole Oceanographic Institution; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of California System; University of California Santa Cruz; University of Ottawa
  摘要：During wildfires and fossil fuel combustion, biomass is converted to black carbon (BC) via incomplete combustion. BC enters the ocean by rivers and atmospheric deposition contributing to the marine dissolved organic carbon (DOC) pool. The fate of BC is considered to reside in the marine DOC pool, where the oldest BC C-14 ages have been measured (>20,000 C-14 y), implying long-term storage. DOC is the largest exchangeable pool of organic carbon in the oceans, yet most DOC (>80%) remains molecul...
• IL7 increases targeted lipid nanoparticle-mediated mRNA expression in T cells in vitro and in vivo by enhancing T cell protein translation AI翻译
  作者：Tilsed, Caitlin M.; Sadiq, Barzan A.; Papp, Tyler E.; Areesawangkit, Phurin; Kimura, Kenji; Noguera-Ortega, Estela; Scholler, John; Cerda, Nicholas; Aghajanian, Haig; Bot, Adrian; Mui, Barbara; Tam, Ying; Weissman, Drew; June, Carl H.; Albelda, Steven M.; Parhiz, Hamideh
  作者单位：University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; Mahidol University
  摘要：The use of lipid nanoparticles (LNP) to encapsulate and deliver mRNA has become an important therapeutic advance. In addition to vaccines, LNP-mRNA can be used in many other applications. For example, targeting the LNP with anti-CD5 antibodies (CD5/tLNP) can allow for efficient delivery of mRNA payloads to T cells to express protein. As the percentage of protein expressing T cells induced by an intravenous injection of CD5/tLNP is relatively low (4- 20%), our goal was to find ways to increase ...
• Exchangeable manganese regulates carbon storage in the humus layer of the boreal forest AI翻译
  作者：Zhang, Yunyu; Hobbiec, Sarah E.; Schlesinger, William H.; Berg, Bjorn; Sun, Tao; Zhu, Jiaojun
  作者单位：Chinese Academy of Sciences; Shenyang Institute of Applied Ecology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of Minnesota System; University of Minnesota Twin Cities; Duke University; University of Helsinki; Chinese Academy of Sciences
  摘要：The huge carbon stock in humus layers of the boreal forest plays a critical role in the global carbon cycle. However, there remains uncertainty about the factors that regulate below- ground carbon sequestration in this region. Notably, based on evidence from two independent but complementary methods, we identified that exchangeable manganese is a critical factor regulating carbon accumulation in boreal forests across both regional scales and the entire boreal latitudinal range. Moreover, in a ...
• Dual topologies of myotomal collagen XV and Tenascin C act in concert to guide and shape developing motor axons AI翻译
  作者：Nemoz-Billet, Laurie; Balland, Martial; Gilquin, Laurent; Gillet, Benjamin; Stevant, Isabelle; Guillon, Emilie; Hughes, Sandrine; Carpentier, Gilles; Vaganay, Elisabeth; Sohm, Frederic; Misiak, Vladimir; Melo, Mary-Julieth Gonzalez-; Koch, Manuel; Ghavi-Helm, Yad; Bretaud, Sandrine; Ruggiero, Florence
  作者单位：Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); INRAE; CHU Lyon; Ecole Normale Superieure de Lyon (ENS de LYON); Universite Claude Bernard Lyon 1; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Centre National de la Recherche Scientifique (CNRS); Universite Paris-Est-Creteil-Val-de-Marne (UPEC); University of Cologne
  摘要：During development, motor axons are guided toward muscle target by various extrinsic cues including extracellular matrix (ECM) proteins whose identities and cellular source remain poorly characterized. Here, using single - cell RNAseq of sorted GFP+ cells from smyhc1:gfp- injected zebrafish embryos, we unravel the slow muscle progenitors (SMP) pseudotemporal trajectory at the single - cell level and show that differentiating SMPs are a major source of ECM proteins. The SMP core- matrisome was ...
• Sleep deprivation drives brain- wide changes in cholinergic presynapse abundance in Drosophila melanogaster AI翻译
  作者：Weiss, Jacqueline T.; Blundell, Mei Z.; Singh, Prabhjit; Donlea, Jeffrey M.
  作者单位：University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Davis
  摘要：Sleep is an evolutionarily conserved state that supports brain functions, including synsimilar cell type-specific trends in plasticity occur broadly across the brain, we used a flp- based genetic reporter to label presynaptic BRP in cholinergic, dopaminergic, GABAergic, or glutamatergic neurons. We then collected whole- brain confocal image stacks of BRP intensity to systematically quantify BRP, a marker of presynapse abundance, across 37 neuropil regions of the central fly brain. Our results ...