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作者：Sun, Mengge; Gao, Yanjing; Li, Zhenmeiyu; Yang, Lin; Liu, Guoping; Xu, Zhejun; Guo, Rongliang; You, Yan; Yang, Zhengang
作者单位：Fudan University; Fudan University; Fudan University
摘要：The molecular basis for cortical expansion during evolution remains largely unknown. Here, we report that fibroblast growth factor (FGF)- extracellular signal- regulated kinase (ERK) signaling promotes the self-renewal and expansion of cortical radial glial (RG) cells. Furthermore, FGF-ERK signaling induces bone morphogenic protein 7 (Bmp7) expression in cortical RG cells, which increases the length of the neurogenic period. We demonstrate that ERK signaling and Sonic Hedgehog (SHH) signaling ...
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作者：Jing, Xiaoyang; Wu, Fandi; Luo, Xiao; Xu, Jinbo
作者单位：Chinese Academy of Sciences; Institute of Computing Technology, CAS; Toyota Technological Institute - Chicago
摘要：Protein structure prediction has been greatly improved by deep learning in the past few years. However, the most successful methods rely on multiple sequence alignment (MSA) of the sequence homologs of the protein under prediction. In nature, a protein folds in the absence of its sequence homologs and thus, a MSA-free structure prediction method is desired. Here, we develop a single-sequence-based protein structure prediction method RaptorX-Single by integrating several protein language models...
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作者：Ambegaonkar, Abhijit A.; Holla, Prasida; Sohn, Haewon; George, Rachel; Tran, Tuan M.; Pierce, Susan K.
作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); Indiana University System; Indiana University Bloomington; Regeneron; Indiana University System; Indiana University Bloomington
摘要：Memory B cells (MBCs) play a critical role in protection against homologous and variant pathogen challenge by either differentiating to plasma cells (PCs) or to germinal center (GC) B cells. The human MBC compartment contains both switched IgG+ and unswitched IgM+ MBCs; however, whether these MBC subpopulations are equivalent in their response to B cell receptor cross- linking and their resulting fates is incompletely understood. Here, we show that IgG+ and IgM+ MBCs can be distinguished based...
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作者：Moharramipour, Ali; Lau, Hakwan
作者单位：RIKEN
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作者：Zhang, Xiao-Xiao; Nagaosa, Naoto
作者单位：Huazhong University of Science & Technology; Huazhong University of Science & Technology; RIKEN
摘要：Weyl semimetal showing open -arc surface states is a prominent example of topological quantum matter in three dimensions. With the bulk -boundary correspondence present, nontrivial surface-bulk hybridization is inevitable but less understood. Spectroscopies have been often limited to verifying the existence of surface Fermi arcs, whereas its spectral shape related to the hybridization profile in energy-momentum space is not well studied. We present an exactly solvable formalism at the surface ...
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作者：Zou, Xiaoxiao; Xie, Jiyang; Mei, Zhiyuan; Jing, Qi; Sheng, Xuelin; Zhang, Conghui; Yang, Yongxin; Sun, Mengjiao; Ren, Futong; Wang, Lilian; He, Tianwei; Kong, Youchao; Guo, Hong
作者单位：Yunnan University; Yancheng Teachers University
摘要：High- entropy alloy nanoparticles (HEANs) possessing regulated defect structure and electron interaction exhibit a guideline for constructing multifunctional catalysts. However, the microstructure-activity relationship between active sites of HEANs for multifunctional electrocatalysts is rarely reported. In this work, HEANs distributed on multi- walled carbon nanotubes (HEAN/CNT) are prepared by Joule heating as an example to explain the mechanism of trifunctional electrocatalysis for oxygen r...
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作者：D'Aria, Stefania; Maquet, Celine; Li, Shuang; Dhup, Suveera; Lepez, Anouk; Kohler, Arnaud; Hee, Vincent F. Van; Dadhich, Rajesh K.; Freniere, Marine; Andris, Fabienne; Nemazanyy, Ivan; Sonveauxf, Pierre; Machiels, Benedicte; Gillet, Laurent; Braun, Michel Y.
作者单位：Universite Libre de Bruxelles; University of Liege; Universite Catholique Louvain; Universite Libre de Bruxelles; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Universite Paris Cite
摘要：Lactate-proton symporter monocarboxylate transporter 1 (MCT1) facilitates lactic acid export from T cells. Here, we report that MCT1 is mandatory for the development of virus- specific CD8+ T cell memory. MCT1- deficient T cells were exposed to acute pneumovirus (pneumonia virus of mice, PVM) or persistent gamma-herpesvirus (Murid herpesvirus 4, MuHV-4) infection. MCT1 was required for the expansion of virus - specific CD8+ T cells and the control of virus replication in the acute phase of inf...
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作者：Qu, Xinjing; Li, Xiaogang; Bardgett, Richard D.; Kuzyakov, Yakov; Revillini, Daniel; Sonne, Christian; Xia, Changlei; Ruan, Honghua; Liu, Yurong; Cao, Fuliang; Reich, Peter B.; Delgado-Baquerizo, Manuel
作者单位：Nanjing Forestry University; Nanjing Forestry University; University of Manchester; University of Gottingen; Peoples Friendship University of Russia; Kazan Federal University; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Recursos Naturales y Agrobiologia de Sevilla (IRNAS); Aarhus University; Nanjing Forestry University; Huazhong Agricultural University; University of Minnesota System; University of Minnesota Twin Cities; University of Michigan System; University of Michigan
摘要：Deforestation poses a global threat to biodiversity and its capacity to deliver ecosys-tem services. Yet, the impacts of deforestation on soil biodiversity and its associated ecosystem services remain virtually unknown. We generated a global dataset including 696 paired- site observations to investigate how native forest conversion to other land uses affects soil properties, biodiversity, and functions associated with the delivery of multiple ecosystem services. The conversion of native forest...
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作者：Han, Xinlu; Wang, Deyu; Yang, Liao; Wang, Ning; Shen, Jianliang; Wang, Jinghan; Zhang, Lei; Chen, Li; Gao, Shenglan; Zong, Wei-Xing; Wang, Yongbo
作者单位：Fudan University; Chinese Academy of Sciences; Shanghai Institute of Nutrition & Health, CAS; University of Chinese Academy of Sciences, CAS; Rutgers University System; Rutgers University New Brunswick; Fudan University; Fudan University; Fudan University; Fudan University; Fudan University
摘要：Polyamines are a class of small polycationic alkylamines that play essential roles in both normal and cancer cell growth. Polyamine metabolism is frequently dysregulated and considered a therapeutic target in cancer. However, targeting polyamine metabolism as monotherapy often exhibits limited efficacy, and the underlying mechanisms are incompletely understood. Here we report that activation of polyamine catabolism promotes glutamine metabolism, leading to a targetable vulnerability in lung ca...
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作者：Meng, Xiangyu; Wang, Xin; Yin, Kuibo; Jing, Yao; Gu, Liuning; Tao, Zequan; Ren, Xinchuan; Tang, Mingyu; Shao, Xinxing; Sun, Litao; Sun, Yueming; Dai, Yunqian; Xiong, Yujie
作者单位：Southeast University - China; Anhui Normal University; Southeast University - China; Southeast University - China; Chinese Academy of Sciences; University of Science & Technology of China, CAS
摘要：Photothermal heating and photocatalytic treatment are two solar- driven water processing approaches by harnessing NIR and UV-vis light, respectively, which can fully utilize solar energy if integrated. However, it remains a challenge to achieve high performance in both approaches when integrated in a material due to uncontrollable heat diffusion. Here, we report a demonstration of heat confinement on photothermal sites and fluid cooling on photocatalysis sites at the nanoscale, within a well- ...
