26期

最新文章

• Successful use of anti-CD19 CAR T cells in severe treatment- refractory stiff- person syndrome AI翻译
  作者：Faissner, Simon; Motte, Jeremias; Sgodzai, Melissa; Geis, Christian; Haghikia, Aiden; Mougiakakos, Dimitrios; Borie, Dominic; Schroers, Roland; Gold, Ralf
  作者单位：Ruhr University Bochum; Friedrich Schiller University of Jena; Otto von Guericke University; Otto von Guericke University; Ruhr University Bochum
  摘要：Treatment with autologous chimeric antigen receptor (CAR) T cells has emerged as a highly effective approach in neuroimmunological disorders such as myasthenia gravis. We report a case of successful anti - CD19 CAR T cell use in treatment - refractory stiff - person syndrome (SPS). To investigate clinical and immunological effects of anti - CD19 CAR T cell use in treatment - refractory SPS, a 69 - y - old female with a 9 - y history of treatment - refractory SPS with deteriorating episodes of ...
• Ultrafast generation of hidden phases via energy-tuned electronic photoexcitation in magnetite AI翻译
  作者：Truc, B.; Usai, P.; Pennacchio, F.; Berruto, G.; Claude, R.; Madan, I.; Sala, V.; LaGrange, T.; Vanacore, G. M.; Benhabib, S.; Carbone, F.
  作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Polytechnic University of Milan; University of Milano-Bicocca; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS)
  摘要：Phase transitions occurring in nonequilibrium conditions can evolve through high -energy intermediate states inaccessible via equilibrium adiabatic conditions. Because of the subtle nature of such hidden phases, their direct observation is extremely challenging and requires simultaneous visualization of matter at subpicoseconds and subpicometer scales. Here, we show that a magnetite crystal in the vicinity of its metal-to-insulator transition evolves through different hidden states when contro...
• Functional effects of mutations in proteins can be predicted and interpreted by guided selection of sequence covariation information AI翻译
  作者：Cocco, Simona; Posani, Lorenzo; Monasson, Remi
  作者单位：Universite PSL; Ecole Normale Superieure (ENS); Sorbonne Universite; Universite Paris Cite; Sorbonne Universite; Columbia University
  摘要：Predicting the effects of one or more mutations to the in vivo or in vitro properties of a wild -type protein is a major computational challenge, due to the presence of epistasis, that is, of interactions between amino acids in the sequence. We introduce a computationally efficient procedure to build minimal epistatic models to predict mutational effects by combining evolutionary (homologous sequence) and few mutational -scan data. Mutagenesis measurements guide the selection of links in a spa...
• A niche- derived nonribosomal peptide triggers planarian sexual development AI翻译
  作者：Issigonis, Melanie; Browder, Katherine L.; Chen, Rui; Collins III, James J.; Newmark, Phillip A.
  作者单位：University of Wisconsin System; University of Wisconsin Madison; The Morgridge Institute for Research, Inc.; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Texas System; University of Texas Southwestern Medical Center
  摘要：Germ cells are regulated by local microenvironments (niches), which secrete instructive cues. Conserved developmental signaling molecules act as niche - derived regulatory factors, yet other types of niche signals remain to be identified. Single - cell RNA - sequencing of sexual planarians revealed niche cells expressing a nonribosomal peptide synthetase ( nrps ). Inhibiting nrps led to loss of female reproductive organs and testis hyperplasia. Mass spectrometry detected the dipeptide beta- al...
• Structural basis for activation of somatostatin receptor 5 by cyclic neuropeptide agonists AI翻译
  作者：Li, Jingru; You, Chongzhao; Li, Yang; Li, Changyao; Fan, Wenjia; Chen, Zecai; Hu, Wen; Wu, Kai; Xu, H. Eric; Zhao, Li-Hua
  作者单位：Nanjing University of Chinese Medicine; Chinese Academy of Sciences; Shanghai Institute of Materia Medica, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Lingang Laboratory; ShanghaiTech University
  摘要：Somatostatin receptor 5 (SSTR5) is an important G protein-coupled receptor and drug target for neuroendocrine tumors and pituitary disorders. This study presents two high- resolution cryogenicelectron microscope structures of the SSTR5-Gi complexes bound to the cyclic neuropeptide agonists, cortistatin-17 (CST17) and octreotide, with resolutions of 2.7 & Aring; and 2.9 & Aring;, respectively. The structures reveal that binding of these peptides causes rearrangement of a hydrophobic lock, consi...
• Diversity and evolution of nitric oxide reduction in bacteria and archaea AI翻译
  作者：Murali, Ranjani; Pace, Laura A.; Sanford, Robert A.; Ward, L. M.; Lynes, Mackenzie M.; Hatzenpichler, Roland; Lingappa, Usha F.; Fischer, Woodward W.; Gennis, Robert B.; Hemp, James
  作者单位：University of Illinois System; University of Illinois Urbana-Champaign; California Institute of Technology; Nevada System of Higher Education (NSHE); University of Nevada Las Vegas; University of Illinois System; University of Illinois Urbana-Champaign; Smith College; California Institute of Technology; Montana State University System; Montana State University Bozeman; Montana State University System; Montana State University Bozeman; Montana State University System; Montana State University Bozeman; University of California System; University of California Berkeley
  摘要：Nitrous oxide is a potent greenhouse gas whose production is catalyzed by nitric oxide reductase (NOR) members of the heme - copper oxidoreductase (HCO) enzyme superfamily. We identified several previously uncharacterized HCO families, four of which (eNOR, sNOR, gNOR, and nNOR) appear to perform NO reduction. These families have novel active - site structures and several have conserved proton channels, suggesting that they might be able to couple NO reduction to energy conservation. We isolate...
• 3.3 million years of stone tool complexity suggests that cumulative culture began during the Middle Pleistocene AI翻译
  作者：Paige, Jonathan; Perreault, Charles
  作者单位：University of Missouri System; University of Missouri Columbia; Arizona State University; Arizona State University-Tempe
  摘要：Cumulative culture, the accumulation of modifications, innovations, and improvements over generations through social learning, is a key determinant of the behavioral diversity across Homo sapiens populations and their ability to adapt to varied ecological habitats. Generations of improvements, modifications, and lucky errors allow humans to use technologies and know-how well beyond what a single naive individual could invent independently within their lifetime. The human dependence on cumulati...
• Path- dependence of the Plio-Pleistocene glacial/interglacial cycles AI翻译
  作者：Carrillo, Judit; Mann, Michael E.; Larson, Christopher J.; Christiansen, Shannon; Willeit, Matteo; Ganopolski, Andrey; Li, Xueke; Murphy, Jack G.
  作者单位：University of Pennsylvania; Potsdam Institut fur Klimafolgenforschung
  摘要：We find strong path dependence in the evolution of the Plio-Pleistocene glaciations using CLIMBER - 2 Earth System Model simulations from the mid - Pliocene to modern preindustrial (3 My - 0 My BP) driven by a gradual decrease in volcanic carbon dioxide outgassing and regolith removal from basal ice interaction. Path dependence and hysteresis are investigated by alternatively driving the model forward and backward in time. Initiating the model with preindustrial conditions and driving the mode...
• Predicted hot superconductivity in LaSc2H24 under pressure AI翻译
  作者：He, Xin-Ling; Zhao, Wenbo; Xie, Yu; Hermann, Andreas; Hemley, Russell J.; Liu, Hanyu; Ma, Yanming
  作者单位：Jilin University; Henan Academy of Sciences; Jilin University; University of Edinburgh; University of Edinburgh; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; Jilin University
  摘要：The recent theory- driven discovery of a class of clathrate hydrides (e.g., CaH6, YH6, YH9, and LaH10) with superconducting critical temperatures (Tc) well above 200 K has opened the prospects for hot superconductivity above room temperature under pressure. Recent efforts focus on the search for superconductors among ternary hydrides that accommodate more diverse material types and configurations compared to binary hydrides. Through extensive computational searches, we report the prediction of...
• Calorie restriction and calorie- restriction mimetics activate chaperone- mediated autophagy AI翻译
  作者：Jafari, Maryam; Macho-Gonzalez, Adrian; Diaz, Antonio; Lindenau, Kristen; Fernandez, Olaya Santiago-; Zeng, Mei; Massey, Ashish C.; de Cabo, Rafael; Kaushik, Susmita; Cuervo, Ana Maria
  作者单位：Yeshiva University; Montefiore Medical Center; Albert Einstein College of Medicine; Montefiore Medical Center; Albert Einstein College of Medicine; Yeshiva University; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA); Yeshiva University; Montefiore Medical Center; Albert Einstein College of Medicine
  摘要：Chaperone- mediated autophagy (CMA) is part of the mammalian cellular proteostasis network that ensures protein quality control, maintenance of proteome homeostasis, and proteome changes required for the adaptation to stress. Loss of proteostasis is one of the hallmarks of aging. CMA decreases with age in multiple rodent tissues and human cell types. A decrease in lysosomal levels of the lysosome- associated membrane protein type 2A (LAMP2A), the CMA receptor, has been identified as a main rea...