26期

最新文章

• Physical modeling of nucleosome clustering in euchromatin resulting from interactions between epigenetic reader proteins AI翻译
  作者：Wakim, Joseph G.; Spakowitz, Andrew J.
  作者单位：Stanford University; Stanford University; Stanford University; Stanford University
  摘要：Euchromatin is an accessible phase of genetic material containing genes that encode proteins with increased expression levels. The structure of euchromatin in vitro has been described as a 30-nm fiber formed from ordered nucleosome arrays. However, recent advances in microscopy have revealed an in vivo euchromatin architecture that is much more disordered, characterized by variable-length linker DNA and sporadic nucleosome clusters. In this work, we develop a theoretical model to elucidate fac...
• The TOX-RAGE axis mediates inflammatory activation and lung injury in severe pulmonary infectious diseases AI翻译
  作者：Kim, Hyelim; Park, Hee Ho; Kim, Hong Nam; Seo, Donghyuk; Hong, Kyung Soo; Jang, Jong Geol; Seo, Eun U.; Kim, In- Young; Jeon, So- Young; Son, Boram; Cho, Seong-Woo; Kim, Wantae; Ahn, June Hong; Lee, Wonhwa
  作者单位：Korea Institute of Science & Technology (KIST); Yonsei University; Hanyang University; Hanyang University; Yonsei University; Yonsei University; Sungkyunkwan University (SKKU); Yeungnam University; Yeungnam University; University of Seoul
  摘要：Thymocyte selection-associated high - mobility group box (TOX) is a transcription factor that is crucial for T cell exhaustion during chronic antigenic stimulation, but its role in inflammation is poorly understood. Here, we report that TOX extracellularly mediates drastic inflammation upon severe acute respiratory syndrome coronavirus 2 (SARS - CoV - 2) infection by binding to the cell surface receptor for advanced glycation end - products (RAGE). In various diseases, including COVID - 19, TO...
• The time course of person perception from voices in the brain AI翻译
  作者：Lavan, Nadine; Rinke, Paula; Scharinger, Mathias
  作者单位：University of London; Queen Mary University London; Philipps University Marburg; Philipps University Marburg
  摘要：When listeners hear a voice, they rapidly form a complex first impression of who the person behind that voice might be. We characterize how these multivariate first impressions from voices emerge over time across different levels of abstraction using electroencephalography and representational similarity analysis. We find that for eight perceived physical (gender, age, and health), trait (attractiveness, dominance, and trustworthiness), and social characteristics (educatedness and professional...
• A MOZ-TIF2 leukemia mouse model displays KAT6-dependent H3K23 propionylation and overexpression of a set of active developmental genes AI翻译
  作者：Smolko, Anne E.; Sullivan, Daniel W.; Olsen, Sarah Naomi; Kang, Hyuckjoon; Whedon, Samuel D.; Baell, Jonathan B.; Cole, Philip A.; Armstrong, Scott A.; Kuroda, Mitzi I.
  作者单位：Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Monash University; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital
  摘要：Aberrant regulation of chromatin modifiers is a common occurrence across many cancer types, and a key priority is to determine how specific alterations of these proteins, often enzymes, can be targeted therapeutically. MOZ, a histone acyltransferase, is recurrently fused to coactivators CBP, p300, and TIF2 in cases of acute myeloid leukemia (AML). Using either pharmacological inhibition or targeted protein degradation in a mouse model for MOZ - TIF2 - driven leukemia, we show that KAT6 (MOZ/MO...