30期

最新文章

• Cytoplasmic stirring by active carpets AI翻译
  作者：Chakrabarti, Brato; Rachh, Manas; Shvartsman, Stanislav Y.; Shelley, Michael J.
  作者单位：Simons Foundation; Flatiron Institute; Tata Institute of Fundamental Research (TIFR); International Centre for Theoretical Sciences, Bengaluru; Simons Foundation; Flatiron Institute; Princeton University; Princeton University; New York University
  摘要：Large cells often rely on cytoplasmic flows for intracellular transport, maintaining homeostasis, and positioning cellular components. Understanding the mechanisms of these flows is essential for gaining insights into cell function, developmental processes, and evolutionary adaptability. Here, we focus on a class of self-organized cytoplasmic stirring mechanisms that result from fluid-structure interactions between cytoskeletal elements at the cell cortex. Drawing inspiration from streaming fl...
• The receptor- like kinase ARK controls symbiotic balance across land plants AI翻译
  作者：Sgroi, Mara; Hoey, David; Jimenez, Karina Medina; Bowden, Sarah L.; Hope, Matthew; Wallington, Emma J.; Schornack, Sebastian; Bravo, Armando; Paszkowski, Uta
  作者单位：University of Cambridge; University of Cambridge; Donald Danforth Plant Science Center
  摘要：The mutualistic arbuscular mycorrhizal (AM) symbiosis arose in land plants more than 450 million years ago and is still widely found in all major land plant lineages. Despite its broad taxonomic distribution, little is known about the molecular components underpinning symbiosis outside of flowering plants. The ARBUSCULAR RECEPTOR- LIKE KINASE (ARK) is required for sustaining AM symbiosis in distantly related angiosperms. Here, we demonstrate that ARK has an equivalent role in symbiosis mainten...
• Transcriptional drift in aging cells: A global decontroller AI翻译
  作者：Matsuzaki, Tyler; Weistuch, Corey; de Graff, Adam; Dill, Ken A.; Balazsi, Gabor
  作者单位：State University of New York (SUNY) System; Stony Brook University; Memorial Sloan Kettering Cancer Center; State University of New York (SUNY) System; Stony Brook University; State University of New York (SUNY) System; Stony Brook University
  摘要：As cells age, they undergo a remarkable global change: In transcriptional drift, hundreds of genes become overexpressed while hundreds of others become underexpressed. Using archetype modeling and Gene Ontology analysis on data from aging Caenorhabditis elegans worms, we find that the up-regulated genes code for sensory proteins upstream of stress responses and down-regulated genes are growth- and metabolism-related. We observe similar trends within human fibroblasts, suggesting that this proc...
• Drosophila neuronal Glucose-6-Phosphatase is a modulator of neuropeptide release that regulates muscle glycogen stores via FMRFamide signaling AI翻译
  作者：Miyamoto, Tetsuya; Hedjazi, Sheida; Miyamoto, Chika; Amrein, Hubert
  作者单位：Texas A&M University System; Texas A&M University College Station
  摘要：Neuropeptides (NPs) and their cognate receptors are critical effectors of diverse physiological processes and behaviors. We recently reported of a noncanonical function of the Drosophila Glucose- 6- Phosphatase (G6P) gene in a subset of neurosecretory cells in the central nervous system that governs systemic glucose homeostasis in food- deprived flies. Here, we show that G6P- expressing neurons define six groups of NP- secreting cells, four in the brain and two in the thoracic ganglion. Using ...
• Ancient genomes reveal over two thousand years of dingo population structure AI翻译
  作者：Souilmi, Yassine; Wasef, Sally; Williams, Matthew P.; Conroy, Gabriel; Bar, Ido; Bover, Pere; Dann, Jackson; Heiniger, Holly; Llamas, Bastien; Ogbourne, Steven; Archer, Michael; Ballard, J. William O.; Reed, Elizabeth; Tobler, Raymond; Koungoulos, Loukas; Walshe, Keryn; Wright, Joanne L.; Balme, Jane; O'Connor, Sue; Cooper, Alan; Mitchell, Kieren J.
  作者单位：University of Adelaide; University of Adelaide; Queensland University of Technology (QUT); Queensland Health; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; University of the Sunshine Coast; University of the Sunshine Coast; Griffith University; University of Zaragoza; University of Adelaide; Australian National University; John Curtin School of Medical Research; University of Western Australia; The Kids Research Institute Australia; University of New South Wales Sydney; University of Melbourne; University of Adelaide; Australian National University; Australian National University; Australian Museum; Australian National University; University of Auckland; University of Western Australia; Charles Sturt University; Landcare Research - New Zealand
  摘要：Dingoes are culturally and ecologically important free- living canids whose ancestors arrived in Australia over 3,000 B.P., likely transported by seafaring people. However, the early history of dingoes in Australia-including the number of founding populations and their routes of introduction-remains uncertain. This uncertainty arises partly from the complex and poorly understood relationship between modern dingoes and New Guinea singing dogs, and suspicions that post- Colonial hybridization ha...
• Tether- scanning the kinesin motor domain reveals a core mechanical action AI翻译
  作者：Sumiyoshi, Rieko; Yamagishi, Masahiko; Furuta, Akane; Nishizaka, Takayuki; Furuta, Ken'ya; Cross, Robert A.; Yajima, Junichiro
  作者单位：University of Tokyo; University of Tokyo; National Institute of Information & Communications Technology (NICT) - Japan; Gakushuin University; University of Warwick; University of Tokyo
  摘要：Natural kinesin motors are tethered to their cargoes via short C- terminal or N- terminal linkers, whose docking against the core motor domain generates directional force. It remains unclear whether linker docking is the only process contributing directional force or whether linker docking is coupled to and amplifies an underlying, more fundamental force- generating mechanical cycle of the kinesin motor domain. Here, we show that kinesin motor domains tethered via double- stranded DNAs (dsDNAs...
• Metformin synergizes with PD-1 blockade to promote normalization of tumor vessels via CD8T cells and IFNγ AI翻译
  作者：Tokumasu, Miho; Nishida, Mikako; Zhao, Weiyang; Chao, Ruoyu; Imano, Natsumi; Yamashita, Nahoko; Hida, Kyoko; Naito, Hisamichi; Udono, Heiichiro
  作者单位：Okayama University; Hokkaido University; Hokkaido University; Kanazawa University
  摘要：Tumor blood vessels are highly leaky in structure and have poor blood perfusion, which hampers infiltration and function of CD8T cells within tumor. Normalizing tumor vessels is thus thought to be important in promoting the flux of immune T cells and enhancing ant- tumor immunity. However, how tumor vasculature is normalized is poorly understood. Metformin (Met) combined with ant- PD- 1 therapy is known to stimulate proliferation of and to produce large amounts of IFN gamma from tumor- infiltr...
• The pathogenic T42A mutation in SHP2 rewires the interaction specificity of its N- terminal regulatory domain AI翻译
  作者：Vlimmeren, Anne E. van; Voleti, Rashmi; Chartier, Cassandra A.; Jiang, Ziyuan; Karandur, Deepti; Humphries, Preston A.; Lo, Wan- Lin; Shah, Neel H.
  作者单位：Columbia University; Columbia University; Vanderbilt University; Utah System of Higher Education; University of Utah
  摘要：Mutations in the tyrosine phosphatase Src homology- 2 domain- containing protein tyrosine phosphatase-2 (SHP2) are associated with a variety of human diseases. Most mutations in SHP2 increase its basal catalytic activity by disrupting autoinhibitory interactions between its phosphatase domain and N- terminal SH2 (phosphotyrosine recognition) domain. By contrast, some disease- associated mutations located in the ligand- binding pockets of the N- or C- terminal SH2 domains do not increase basal ...
• GIGANTEA adjusts the response to shade at dusk by directly impinging on PHYTOCHROME INTERACTING FACTOR 7 function AI翻译
  作者：Martinez-Vasallo, Carlos; Cole, Benjamin; Perez-Alemany, Jaime; Ortiz-Ramirez, Clara I.; Gallego-Bartolome, Javier; Chory, Joanne; Kay, Steve A.; Nohales, Maria A.
  作者单位：Consejo Superior de Investigaciones Cientificas (CSIC); Universitat Politecnica de Valencia; CSIC-UPV - Instituto de Biologia Molecular y Celular de Plantas (IBMCP); University of Southern California; Salk Institute; Howard Hughes Medical Institute; United States Department of Energy (DOE); Joint Genome Institute - JGI; Lawrence Berkeley National Laboratory
  摘要：For plants adapted to bright light, a decrease in the amount of light received can be detrimental to their growth and survival. Consequently, in response to shade from surrounding vegetation, they initiate a suite of molecular and morphological changes known as the shade avoidance response through which stems and petioles elongate in search for light. Under sunlight-night cycles, the plant's responsiveness to shade varies across the day, being maximal at dusk time. While a role for the circadi...
• Information structure in Makhuwa: Electrophysiological evidence for a universal processing account AI翻译
  作者：Verdonschot, Rinus G.; van der Wal, Jenneke; Lewis, Ashley; Knudsen, Birgit; Wolfsthurn, Sarah von Grebmer zu; Schiller, Niels O.; Hagoort, Peter
  作者单位：Max Planck Society; Leiden University; Leiden University - Excl LUMC; Radboud University Nijmegen; Leiden University; Leiden University Medical Center (LUMC); City University of Hong Kong
  摘要：There is evidence from both behavior and brain activity that the way information is structured, through the use of focus, can up- regulate processing of focused constituents, likely to give prominence to the relevant aspects of the input. This is hypothesized to be universal, regardless of the different ways in which languages encode focus. In order to test this universalist hypothesis, we need to go beyond the more familiar linguistic strategies for marking focus, such as by means of intonati...