-
作者：Patel, Rickesh N.; Roberts, Natalie S.; Kempenaers, Julian; Zadel, Ana; Heinze, Stanley
作者单位：Lund University; Lund University
摘要：Insects rely on path integration (vector- based navigation) and landmark guidance to perform sophisticated navigational feats, rivaling those seen in mammals. Bees in particular exhibit complex navigation behaviors including creating optimal routes and novel shortcuts between locations, an ability historically indicative of the presence of a cognitive map. A mammalian cognitive map has been widely accepted. However, in insects, the existence of a centralized cognitive map is highly contentious...
-
作者：Turcotte, Lucie M.; Wang, Tao; Beyer, Kirsten M.; Cole, Steven W.; Spellman, Stephen R.; Johnson, Mariam Allbee -; Williams, Eric; Zhou, Yuhong; Verneris, Michael R.; Rizzo, J. Douglas; Knight, Jennifer M.
作者单位：University of Minnesota System; University of Minnesota Twin Cities; Center for International Blood & Marrow Transplant Research; Medical College of Wisconsin; Medical College of Wisconsin; Medical College of Wisconsin; University of California System; University of California Los Angeles; National Marrow Donor Program; Center for International Blood & Marrow Transplant Research; Children's Hospital Colorado; University of Colorado System; University of Colorado Denver; University of Colorado Anschutz Medical Campus; Medical College of Wisconsin; Medical College of Wisconsin
摘要：Low socioeconomic status (SES) is a risk factor for mortality and immune dysfunction across a wide range of diseases, including cancer. However, cancer is distinct in the use of allogeneic hematopoietic cell transplantation (HCT) as a treatment for hematologic malignancies to transfer healthy hematopoietic cells from one person to another. This raises the question of whether social disadvantage of an HCT cell donor, as assessed by low SES, might impact the subsequent health outcomes of the HCT...
-
作者：Shen, Shuying; Liang, Yi; Zhao, Yuening; Hu, Ziang; Huang, Youling; Wu, Yizheng; Liu, Yufei; Fan, Shunwu; Wang, Qingqing; Xiao, Peng
作者单位：Zhejiang University; Zhejiang University; Zhejiang University
摘要：As the primary cause for chronic pain and disability in elderly individuals, osteoarthritis (OA) is one of the fastest- growing diseases due to the aging world population. To date, the impact of microenvironmental changes on the pathogenesis of OA remains poorly understood, greatly hindering the development of effective therapeutic approaches against OA. In this study, we profiled the differential metabolites in the synovial fluid from OA patients and identified the downregulation of vitamin B...
-
作者：Li, Yong; Wen, Yiling; Li, Ying; Tan, Xinyi; Gao, Shuaixin; Fan, Peiyao; Tian, Wenmin; Wong, Catherine C. L.; Chen, Yang
作者单位：Peking University; Peking University; Tsinghua University; Chinese Academy of Sciences; Institute of Biophysics, CAS; University System of Ohio; Ohio State University; James Cancer Hospital & Solove Research Institute; University System of Ohio; Ohio State University; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College
摘要：Migrasomes, vesicular organelles generated on the retraction fibers of migrating cells, play a crucial role in migracytosis, mediating intercellular communication. The cargoes determine the functional specificity of migrasomes. Migrasomes harbor numerous intraluminal vesicles, a pivotal component of their cargoes. The mechanism underlying the transportation of these intraluminal vesicles to the migrasomes remains enigmatic. In this study, we identified that Rab10 and Caveolin- 1 (CAV1) mark th...
-
作者：Mason, Alexander H.; Motta, Alessandro; Kratish, Yosi; Marks, Tobin J.
作者单位：Northwestern University; Northwestern University; Sapienza University Rome
摘要：A kinetic/mechanistic investigation of gaseous propane hydrogenolysis over the single-site heterogeneous polyolefin depolymerization catalysts AlS/ZrNp2 and AlS/HfNp2 (AlS = sulfated alumina, Np = neopentyl), is use to probe intrinsic catalyst properties without the complexities introduced by time- and viscosity-dependent polymer medium effects. In a polymer-free automated plug-flow catalytic reactor, propane hydrogenolysis turnover frequencies approach 3,000 h(-1) at 150 degrees C. Both catal...
-
作者：Zhou, Qixing; Xue, Wendan; Cui, Xun; Wang, Pengfei; Zuo, Sijin; Mo, Fan; Li, Chengzhi; Liu, Gaolei; Ouyang, Shaohu; Zhan, Sihui; Chen, Juan; Wang, Chao
作者单位：Nankai University; Wuhan Textile University; China Pharmaceutical University; Hohai University
摘要：Rechargeable zinc-air batteries (ZABs) are regarded as a remarkably promising alternative to current lithium- ion batteries, addressing the requirements for large- scale high- energy storage. Nevertheless, the sluggish kinetics involving oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) hamper the widespread application of ZABs, necessitating the development of high- efficiency and durable bifunctional electrocatalysts. Here, we report oxygen atom-bridged Fe, Co dual- metal d...
-
作者：He, Jinfeng; Tong, Yun; Wang, Zhe; Zhou, Guorong; Ren, Xuhui; Zhu, Jiaye; Zhang, Nan; Chen, Lu; Chen, Pengzuo
作者单位：Zhejiang Sci-Tech University; University of Cambridge
摘要：High- entropy compounds have been emerging as promising candidates for electrolysis, yet their controllable electrosynthesis strategy remains a formidable challenge because of the ambiguous ionic interaction and codeposition mechanism. Herein, we report a oxygenates directionally induced electrodeposition strategy to construct high- entropy materials with amorphous features, on which the structural evolution from high- entropy phosphide to oxide is confirmed by introducing vanadate, thus reali...
-
作者：Penalva, Daniel A.; Monnappa, Ajay K.; Natale, Paolo; Lopez-Montero, Ivan
作者单位：National University of the South; Instituto de Investigaciones en Ingenieria Electrica (IIIE); Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); National University of the South; Instituto de Investigaciones en Ingenieria Electrica (IIIE); Complutense University of Madrid; Complutense University of Madrid
摘要：Mitofusins (Mfn1 and Mfn2) are the mitochondrial outer- membrane fusion proteins in mammals and belong to the dynamin superfamily of multidomain GTPases. Recent structural studies of truncated variants lacking alpha helical transmembrane domains suggested that Mfns dimerize to promote the approximation and the fusion of the mitochondrial outer membranes upon the hydrolysis of guanine 5 '- triphosphate disodium salt (GTP). However, next to the presence of GTP, the fusion activity seems to requi...
-
作者：Liu, Shujun; Wang, Hong; Hu, Zehui; Zhang, Xin; Sun, Yanjuan; Dong, Fan
作者单位：University of Electronic Science & Technology of China; University of Electronic Science & Technology of China
摘要：Nitrophenols present on the surface of particulates are ubiquitous in the atmosphere. However, its atmospheric photochemical transformation pathway remains unknown, for which the crucial effect of visible light is largely overlooked, resulting in an incomplete understanding of the effects of nitrophenols in the atmospheric environment. This study delves into the photolysis mechanism of 4- nitrophenol (4NP), one of the most abundant atmospheric nitrophenol compounds, on the surface of photoacti...
-
作者：Liu, Ye; Ng, Lily; Liu, Hong; Heuer, Heike; Forrest, Douglas
作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK); University of Duisburg Essen
摘要：The key role of a thyroid hormone receptor in determining the maturation and diversity of cone photoreceptors reflects a profound influence of endocrine signaling on the cells that mediate color vision. However, the route by which hormone reaches cones remains enigmatic as cones reside in the retinal photoreceptor layer, shielded by the blood-retina barrier. Using genetic approaches, we report that cone differentiation is regulated by a membrane transporter for thyroid hormone, MCT8 (SLC16A2),...
