Facile construction of distal and diversified tertiary and quaternary stereocenters

• 成果类型: Article
• 署名作者: Liu, Chong; Ge, Robbie; Chen, Jun; Guo, Hongmei; Bartholome, Tyler A.; Maiti, Debabrata; Ge, Haibo
• 署名单位: Texas Tech University System; Texas Tech University; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Bombay
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-14603
• DOI: 10.1073/pnas.2408541121
• 发表日期: 2024-12-09
• 关键词: catalyzed asymmetric 1; 6-addition; michael addition; heck arylations; functionalization; isomerization; alkenylation; alkenols

摘要

Exploration of novel chiral pharmaceutical candidates is motivation to immersive efforts among synthetic chemists. Achieving skeletal construction and chiral diversity in a highly efficient manner is a momentous goal in the chemical society. Unfortunately, current methods for chiral induction focus primarily on a specific site. Herein, we realized the asymmetric chain- walking arylation of alkenyl alcohols for the construction of multisite tertiary and quaternary stereocenters in high yields and enantioselectivity. This new operation- friendly strategy carries substantial potential for future industrialization.