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作者：Costa, Antonio C.; Ahamed, Tosif; Jordan, David; Stephens, Greg J.
作者单位：Vrije Universiteit Amsterdam; Howard Hughes Medical Institute; University of Cambridge; Okinawa Institute of Science & Technology Graduate University; Universite Paris Cite; Universite PSL; Ecole Normale Superieure (ENS); Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite
摘要：How do we capture the breadth of behavior in animal movement, from rapid body twitches to aging? Using high-resolution videos of the nematode worm Caenorhabditis elegans, we show that a single dynamics connects posture-scale fluctuations with trajectory diffusion and longer-lived behavioral states. We take short posture sequences as an instantaneous behavioral measure, fixing the sequence length for maximal prediction. Within the space of posture sequences, we construct a fine-scale, maximum e...
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作者：Mabry, Alexander R.; Singh, Arnima; Mulrooney, Brianna; Gorman, James; Thielbar, Abigail R.; Wolf, Eric R.; Mayo, Lindsey D.
作者单位：Indiana University System; Indiana University Indianapolis; Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Indianapolis; Indiana University System; Indiana University Indianapolis
摘要：The tumor suppressor von Hippel-Lindau, pVHL, is a multifaceted protein. One function is to dock to the hypoxia- inducible transcription factor (HIF) and recruit a larger protein complex that destabilizes HIF via ubiquitination, preventing angiogenesis and tumor development. pVHL also binds to the tumor suppressor p53 to activate specific p53 target genes. The oncogene Mdm2 impairs the formation of the p53-pVHL complex and activation of downstream genes by conjugating nedd8 to pVHL. While Mdm2...
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作者：Souilmi, Yassine; Wasef, Sally; Williams, Matthew P.; Conroy, Gabriel; Bar, Ido; Bover, Pere; Dann, Jackson; Heiniger, Holly; Llamas, Bastien; Ogbourne, Steven; Archer, Michael; Ballard, J. William O.; Reed, Elizabeth; Tobler, Raymond; Koungoulos, Loukas; Walshe, Keryn; Wright, Joanne L.; Balme, Jane; O'Connor, Sue; Cooper, Alan; Mitchell, Kieren J.
作者单位：University of Adelaide; University of Adelaide; Queensland University of Technology (QUT); Queensland Health; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; University of the Sunshine Coast; University of the Sunshine Coast; Griffith University; University of Zaragoza; University of Adelaide; Australian National University; John Curtin School of Medical Research; University of Western Australia; The Kids Research Institute Australia; University of New South Wales Sydney; University of Melbourne; University of Adelaide; Australian National University; Australian National University; Australian Museum; Australian National University; University of Auckland; University of Western Australia; Charles Sturt University; Landcare Research - New Zealand
摘要：Dingoes are culturally and ecologically important free- living canids whose ancestors arrived in Australia over 3,000 B.P., likely transported by seafaring people. However, the early history of dingoes in Australia-including the number of founding populations and their routes of introduction-remains uncertain. This uncertainty arises partly from the complex and poorly understood relationship between modern dingoes and New Guinea singing dogs, and suspicions that post- Colonial hybridization ha...
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作者：Sumiyoshi, Rieko; Yamagishi, Masahiko; Furuta, Akane; Nishizaka, Takayuki; Furuta, Ken'ya; Cross, Robert A.; Yajima, Junichiro
作者单位：University of Tokyo; University of Tokyo; National Institute of Information & Communications Technology (NICT) - Japan; Gakushuin University; University of Warwick; University of Tokyo
摘要：Natural kinesin motors are tethered to their cargoes via short C- terminal or N- terminal linkers, whose docking against the core motor domain generates directional force. It remains unclear whether linker docking is the only process contributing directional force or whether linker docking is coupled to and amplifies an underlying, more fundamental force- generating mechanical cycle of the kinesin motor domain. Here, we show that kinesin motor domains tethered via double- stranded DNAs (dsDNAs...
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作者：Tokumasu, Miho; Nishida, Mikako; Zhao, Weiyang; Chao, Ruoyu; Imano, Natsumi; Yamashita, Nahoko; Hida, Kyoko; Naito, Hisamichi; Udono, Heiichiro
作者单位：Okayama University; Hokkaido University; Hokkaido University; Kanazawa University
摘要：Tumor blood vessels are highly leaky in structure and have poor blood perfusion, which hampers infiltration and function of CD8T cells within tumor. Normalizing tumor vessels is thus thought to be important in promoting the flux of immune T cells and enhancing ant- tumor immunity. However, how tumor vasculature is normalized is poorly understood. Metformin (Met) combined with ant- PD- 1 therapy is known to stimulate proliferation of and to produce large amounts of IFN gamma from tumor- infiltr...
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作者：Choi, Dongsung; Yue, Changming; Azoury, Doron; Porter, Zachary; Chen, Jiyu; Petocchi, Francesco; Baldini, Edoardo; Lv, Baiqing; Mogi, Masataka; Su, Yifan; Wilson, Stephen D.; Eckstein, Martin; Werner, Philipp; Gedik, Nuh
作者单位：Massachusetts Institute of Technology (MIT); University of Fribourg; Southern University of Science & Technology; Massachusetts Institute of Technology (MIT); University of California System; University of California Santa Barbara; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; University of Texas System; University of Texas Austin; Shanghai Jiao Tong University; University of Tokyo; University of Erlangen Nuremberg; University of Hamburg
摘要：Sr2IrO4 2 IrO 4 has attracted considerable attention due to its structural and electronic similarities to La2CuO4, 2 CuO 4 , the parent compound of high-- T c superconducting cuprates. It was proposed as a strong spin-orbit-- coupled J e ff = 1/2 Mott insulator, but the Mott nature of its insulating ground state has not been conclusively established. Here, we use ultrafast laser pulses to realize an insulator-metal transition in Sr2IrO4 2 IrO 4 and probe the resulting dynamics using time-- and...
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作者：Dokshin, Fedor A.; Gherghina, Mircea
作者单位：University of Toronto
摘要：The perceived risk of climate change and the sense of urgency for an energy transition are both politically polarized, especially in the United States. Yet, we know relatively little about how political polarization affects consumer energy preferences and behav- iors. Here, we use the case of residential solar photovoltaics (PV) in New York State to 1) measure the partisan gap in solar adoption rates and 2) test whether more favorable economics of solar PV mute the effect of political identity...
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作者：Fu, Ziao; MacKinnon, Roderick
作者单位：Rockefeller University; Rockefeller University; Howard Hughes Medical Institute
摘要：In this study, we used cryoelectron microscopy to determine the structures of the Flotillin protein complex, part of the Stomatin, Prohibitin, Flotillin, and HflK/C (SPFH) super- family, from cell-- derived vesicles without detergents. It forms a right- handed helical barrel consisting of 22 pairs of Flotillin1 and Flotillin2 subunits, with a diameter of 32 nm at its wider end and 19 nm at its narrower end. Oligomerization is stabilized by the C terminus, which forms two helical layers linked ...
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作者：Li, Huayao; Wang, Guohua; Ding, Ning; Ren, Quan; Zhao, Gan; Lin, Wenting; Yang, Jinchuan; Yan, Wensheng; Li, Qian; Yang, Run; Yuan, Shijun; Denlinger, Jonathan D.; Wang, Zhenxing; Zhang, Xiaoqian; Wray, L. Andrew; Dong, Shuai; Qian, Dong; Miao, Lin
作者单位：Southeast University - China; Shanghai Jiao Tong University; Chinese Academy of Sciences; University of Science & Technology of China, CAS; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Huazhong University of Science & Technology; Huazhong University of Science & Technology; New York University; Collaborative Innovation Center of Advanced Microstructures (CICAM); Nanjing University; Shanghai Jiao Tong University
摘要：Iron antimonide (FeSb 2 ) has been investigated for decades due to its puzzling electronic properties. It undergoes the temperature- controlled transition from an insulator to an ill- defined metal, with a cross- over from diamagnetism to paramagnetism. Extensive efforts have been made to uncover the underlying mechanism, but a consensus has yet to be reached. While macroscopic transport and magnetic measurements can be explained by different theoretical proposals, the essential spectroscopic ...
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作者：Liu, Zhiguang; Cai, Minkun; Hong, Shenda; Shi, Junli; Xie, Sai; Liu, Chang; Du, Huifeng; Morin, James D.; Li, Gang; Wang, Liu; Wang, Hong; Tang, Ke; Fang, Nicholas X.; Guo, Chuan Fei
作者单位：Southern University of Science & Technology; Massachusetts Institute of Technology (MIT); Chinese Academy of Sciences; University of Science & Technology of China, CAS; Peking University; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Southern University of Science & Technology; University of Hong Kong
摘要：Artificial skins or flexible pressure sensors that mimic human cutaneous mechanoreceptors transduce tactile stimuli to quantitative electrical signals. Conventional trial- and- error designs for such devices follow a forward structure- to- property routine, which is usually time- consuming and determines one possible solution in one run. Data- driven inverse design can precisely target desired functions while showing far higher productivity, however, it is still absent for flexible pressure se...
