2024

最新文章

• METAPHOR: Metabolic evaluation through phasor-based hyperspectral imaging and organelle recognition for mouse blastocysts and oocytes AI翻译
  作者：Parra, Albert; Denkova, Denitza; Burgos-Artizzu, Xavier P.; Aroca, Ester; Casals, Marc; Godeau, Amelie; Ares, Miguel; Ferrer-Vaquer, Anna; Massafret, Ot; Oliver-Vila, Irene; Mestres, Enric; Acacio, Monica; Costa-Borges, Nuno; Rebollo, Elena; Chiang, Hsiao Ju; Fraser, Scott E.; Cutrale, Francesco; Seriola, Anna; Ojosnegros, Samuel
  作者单位：Barcelona Institute of Science & Technology; Institut de Bioenginyeria de Catalunya; University of Barcelona; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Biologia Molecular de Barcelona (IBMB); University of Southern California; University of Southern California; University of Southern California
  摘要：Only 30% of embryos from in vitro fertilized oocytes successfully implant and develop to term, leading to repeated transfer cycles. To reduce time-to-pregnancy and stress for patients, there is a need for a diagnostic tool to better select embryos and oocytes based on their physiology. The current standard employs brightfield imaging, which provides limited physiological information. Here, we introduce METAPHOR: Metabolic Evaluation through Phasor-based Hyperspectral Imaging and Organelle Reco...
• Mortality risk information and health-seeking behavior during an epidemic AI翻译
  作者：Purcell, Helene; Kohler, Iliana, V; Ciancio, Alberto; Mwera, James; Delavande, Adeline; Mwapasa, Victor; Kohler, Hans-Peter
  作者单位：University of Pennsylvania; University of Glasgow; Universidade Nova de Lisboa; University of Technology Sydney
  摘要：In a context where pessimistic survival perceptions have been widespread as a result of the HIV/AIDS epidemic (Fig. 1 A ), we study vaccine uptake and other health behaviors during the recent COVID-19 pandemic. Leveraging a longitudinal cohort study in rural Malawi that has been followed for up to 25 y, we document that a 2017 mortality risk information intervention designed to reduce pessimistic mortality perceptions (Fig. 1 B ) resulted in improved health behavior, including COVID-19 vaccine...
• The chronology of the human colonization of the Canary Islands AI翻译
  作者：Santana, Jonathan; del Pino, Miguel; Morales, Jacob; Fregel, Rosa; Hagenblad, Jenny; Morquecho, Aaron; Mayor, Aitor Brito-; Henriquez, Pedro; Jimenez, Jared; Serrano, Javier G.; Sanchez-Canadillas, Elias; Ordonez, Alejandra C.; Gilson, Simon- Pierre
  作者单位：Universidad de Las Palmas de Gran Canaria; Universidad de la Laguna; Linkoping University
  摘要：The human colonization of the Canary Islands represents the sole known expansion of Berber communities into the Atlantic Ocean and is an example of marine dispersal carried out by an African population. While this island colonization shows similarities to the populating of other islands across the world, several questions still need to be answered before this case can be included in wider debates regarding patterns of initial colonization and human settlement, human-environment interactions, a...
• Progerin forms an abnormal meshwork and has a dominant- negative effect on the nuclear lamina AI翻译
  作者：Kim, Paul H.; Kim, Joonyoung R.; Tu, Yiping; Jung, Hyesoo; Jeong, J. Y. Brian; Tran, Anh P.; Presnell, Ashley; Young, Stephen G.; Fong, Loren G.
  作者单位：University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA
  摘要：nuclear membrane (NM) ruptures and blebs, but the mechanisms are unclear. We susHigh- resolution microscopy of smooth muscle cells (SMCs) revealed that lamin A and lamin B1 form independent meshworks with uniformly spaced openings (-0.085 mu m2). The expression of progerin in SMCs resulted in the formation of an irregular meshwork with clusters of large openings (up to 1.4 mu m2). The expression of progerin acted in a dominant- negative fashion to disrupt the morphology of the endogenous lamin...
• An α- ketoglutarate conformational switch controls iron accessibility, activation, and substrate selection of the human FTO protein AI翻译
  作者：Burns, Daniel; Khatiwada, Balabhadra; Singh, Aayushi; Purslow, Jeffrey A.; Potoyan, Davit A.; Venditti, Vincenzo
  作者单位：Iowa State University; Iowa State University
  摘要：The fat mass and obesity- associated fatso (FTO) protein is a member of the Alkb family N1- methyladenosine (m1A), 3- methylthymine (m3T), and 3- methyluracil (m3U) in single- stranded nucleic acids. It is well established that the catalytic activity of FTO proceeds via two coupled reactions. The first reaction involves decarboxylation of alpha- ketoglutarate (alpha KG) and formation of an oxyferryl species. In the second reaction, the oxyferryl intermediate oxidizes the methylated nucleic aci...
• Gut microbes coordinate pulmonary immunity AI翻译
  作者：Christodoulou, Chryso; Clarke, Thomas B.
  作者单位：Imperial College London
• Synapse-type-specific competitive Hebbian learning forms functional recurrent networks AI翻译
  作者：Eckmann, Samuel; Young, Edward James; Gjorgjieva, Julijana
  作者单位：Max Planck Society; University of Cambridge; Technical University of Munich
  摘要：Cortical networks exhibit complex stimulus-response patterns that are based on specific recurrent interactions between neurons. For example, the balance between excitatory and inhibitory currents has been identified as a central component of cortical computations. However, it remains unclear how the required synaptic connectivity can emerge in developing circuits where synapses between excitatory and inhibitory neurons are simultaneously plastic. Using theory and modeling, we propose that a wi...
• In situ fabrication of atomically adjacent dual- vacancy sites for nearly 100% selective CH4 production AI翻译
  作者：He, Ye; Dai, Sheng; Sheng, Jianping; Ren, Qin; Lv, Yao; Sun, Yanjuan; Dong, Fan
  作者单位：University of Electronic Science & Technology of China; University of Electronic Science & Technology of China; East China University of Science & Technology
  摘要：The photocatalytic CO2- to- CH4 conversion involves multiple consecutive proton- electron coupling transfer processes. Achieving high CH4 selectivity with satisfactory conversion efficiency remains challenging since the inefficient proton and electron delivery path results in sluggish proton-electron transfer kinetics. Herein, we propose the fabrication of atomically adjacent anion-cation vacancy as paired redox active sites that could maximally promote the proton- and electron- donating effic...
• Ca2+ permeation through C-terminal cleaved, but not full- length human Pannexin1 hemichannels, mediates cell death AI翻译
  作者：Salgado, Magdiel; Marquez-Miranda, Valeria; Ferrada, Luciano; Rojas, Maximiliano; Poblete-Flores, Gonzalo; Gonzalez-Nilo, Fernando D.; Ardiles, Alvaro O.; Saez, Juan C.
  作者单位：Universidad de Valparaiso; Universidad Andres Bello; Universidad de Concepcion; Universidad de Valparaiso
  摘要：Pannexin1 hemichannels (Panx1 HCs) are found in the membrane of most mammalian cells and communicate the intracellular and extracellular spaces, enabling the passive transfer of ions and small molecules. They are involved in physiological and pathophysiological conditions. During apoptosis, the C-terminal tail of Panx1 is proteolytically cleaved, but the permeability features of hemichannels and their role in cell death remain elusive. To address these topics, HeLa cells transfected with full-...
• Thermoelectricity at a gallium-mercury liquid metal interface AI翻译
  作者：Vernet, Marlone; Fauve, Stephan; Gissinger, Christophe
  作者单位：Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Ecole Normale Superieure de Lyon (ENS de LYON); Universite PSL; Ecole Normale Superieure (ENS); Universite Paris Cite; Institut Universitaire de France
  摘要：We present experimental evidence of a thermoelectric effect at the interface between two liquid metals. Using superimposed layers of mercury and gallium in a cylindrical vessel operating at room temperature, we provide a direct measurement of the electric current generated by the presence of a thermal gradient along a liquid-liquid interface. At the interface between two liquids, temperature gradients induced by thermal convection lead to a complex geometry of electric currents, ultimately gen...