-
作者：Bhatia, Sangeeta N.; Dahlman, James E.
作者单位：Harvard University; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Howard Hughes Medical Institute; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Harvard University; Emory University; University System of Georgia; Georgia Institute of Technology
-
作者：Guan, Dengfeng; Sun, Shuyan; Song, Lingyun; Zhao, Pengpeng; Nie, Yonggang; Huang, Xin; Zhou, Wenliang; Yan, Li; Lei, Yinghu; Hu, Yibo; Wei, Fuwen
作者单位：Chinese Academy of Sciences; Institute of Zoology, CAS; Jiangxi Agricultural University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Southern Marine Science & Engineering Guangdong Laboratory; Southern Marine Science & Engineering Guangdong Laboratory (Guangzhou)
摘要：Brown- and - white giant pandas (hereafter brown pandas) are distinct coat color mutants found exclusively in the Qinling Mountains, Shaanxi, China. However, its genetic mechanism has remained unclear since their discovery in 1985. Here, we identified the genetic basis for this coat color variation using a combination of field ecological data, population genomic data, and a CRISPR-Cas9 knockout mouse model. We de novo assembled a long- read - based giant panda genome and resequenced the genome...
-
作者：Jamhawi, Nour M.; Koder, Ronald L.; Wittebort, Richard J.
作者单位：University of Louisville; City University of New York (CUNY) System; City University of New York (CUNY) System
摘要：Elastin is an extracellular matrix material found in all vertebrates. Its reversible elasticity, robustness, and low stiffness are essential for the function of arteries, lungs, and skin. It is among the most resilient elastic materials known: During a human lifetime, arterial elastin undergoes in excess of 2 x 109 stretching/contracting cycles without replacement, and slow oxidative hardening has been identified as a limiting factor on human lifespan. For over 50 y, the mechanism of entropic ...
-
作者：Su, Ruidian; Gao, Yixuan; Chen, Long; Chen, Yi; Li, Nan; Liu, Wen; Gao, Baoyu; Li, Qian
作者单位：Shandong University; Peking University; Qingdao University of Science & Technology
摘要：Heterogeneous high-valent cobalt-oxo [equivalent to Co(IV)=O] is a widely focused reactive species in oxidant activation; however, the relationship between the catalyst interfacial defects and equivalent to Co(IV)=O formation remains poorly understood. Herein, photoexcited oxygen vacancies (OVs) were introduced into Co3O4 (OV- Co3O4) by a UV-induced modification method to facilitate chlorite (ClOz) activation. Density functional theory calculations indicate that OVs result in low- coordinated ...
-
作者：Yang, Xiaobin; Li, Yangxue; Wu, Dan; Yan, Linlin; Guan, Jingzhu; Wen, Yajie; Bai, Yongping; Mamba, Bhekie B.; Darling, Seth B.; Shao, Lu
作者单位：Harbin Institute of Technology; Harbin Institute of Technology; University of South Africa; United States Department of Energy (DOE); Argonne National Laboratory; United States Department of Energy (DOE); Argonne National Laboratory; University of Chicago
摘要：Water-energy sustainability will depend upon the rapid development of advanced pressure- driven separation membranes. Although energy- efficient, water- treatment membranes are constrained by ubiquitous fouling, which may be alleviated by engineering self- cleaning membrane interfaces. In this study, a metal- polyphenol network was designed to direct the armorization of catalytic nanofilms (ca. 18 nm) on inert polymeric membranes. The chelation- directed mineralized coating exhibits high polar...
-
作者：Zheng, Kaikai; Ghosh, Shankar; Granick, Steve
作者单位：Institute for Basic Science - Korea (IBS); University of Massachusetts System; University of Massachusetts Amherst; Tata Institute of Fundamental Research (TIFR)
摘要：The usual basis to analyze heat transfer within materials is the equation formulated 200 years ago, Fourier's law, which is identical mathematically to the mass diffusion equation, Fick's law. Revisiting this assumption regarding heat transport within translucent materials, performing the experiments in vacuum to avoid air convection, we compare the model predictions to infrared - based measurements with nearly mK temperature resolution. After heat pulses, we find macroscale non- Gaussian tail...
-
作者：Maldarelli, Charles
作者单位：City University of New York (CUNY) System; City College of New York (CUNY); City University of New York (CUNY) System; City College of New York (CUNY)
-
作者：Rowley-Conwy, Peter
作者单位：Durham University
-
作者：Benedetti, Francesca; Silvestri, Giovannino; Denaro, Frank; Finesso, Giovanni; Contreras-Galindo, Rafael; Munawwar, Arshi; Williams, Sumiko; Davis, Harry; Bryant, Joseph; Wang, Yin; Radaelli, Enrico; Rathinam, Chozha V.; Gallo, Robert C.; Zella, Davide
作者单位：University System of Maryland; University of Maryland Baltimore; University System of Maryland; University of Maryland Baltimore; University System of Maryland; University of Maryland Baltimore; University System of Maryland; University of Maryland Baltimore; Morgan State University; University of Pennsylvania; University of Alabama System; University of Alabama Birmingham; University System of Maryland; University of Maryland Baltimore
摘要：Well- controlled repair mechanisms are involved in the maintenance of genomic stability, and their failure can precipitate DNA abnormalities and elevate tumor risk. In addition, the tumor microenvironment, enriched with factors inducing oxidative stress and affecting cell cycle checkpoints, intensifies DNA damage when repair pathways falter. Recent research has unveiled associations between certain bacteria, including Mycoplasmas, and various cancers, and the causative mechanism(s) are under a...
-
作者：Kretsch, Rachael C.; Xu, Lily; Zheludev, Ivan N.; Zhou, Xueting; Huang, Rui; Nye, Grace; Li, Shanshan; Zhang, Kaiming; Chiu, Wah; Das, Rhiju
作者单位：Stanford University; Stanford University; Stanford University; Stanford University; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Howard Hughes Medical Institute; Stanford University
摘要：Coronavirus genomes sequester their start codons within stem - loop 5 (SL5), a structured, 5 ' genomic RNA element. In most alpha- and betacoronaviruses, the secondary structure of SL5 is predicted to contain a four - way junction of helical stems, some of which are capped with UUYYGU hexaloops. Here, using cryogenic electron microscopy (cryo-EM) and computational modeling with biochemically determined secondary structures, we present three- dimensional structures of SL5 from six coronaviruses...
