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作者：Bai, Long; Li, Peng; Xiang, Yu; Jiao, Xiaofei; Chen, Jiyuan; Song, Licun; Liang, Zhongyang; Liu, Yidan; Zhu, Yimin; Lu, Lin- Yu
作者单位：Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Westlake Laboratory; Westlake University
摘要：In the meiotic prophase, programmed DNA double - strand breaks are repaired by meiotic recombination. Recombination - defective meiocytes are eliminated to preserve genome integrity in gametes. BRCA1 is a critical protein in somatic homologous recombination, but studies have suggested that BRCA1 is dispensable for meiotic recombination. Here we show that BRCA1 is essential for meiotic recombination. Interestingly, BRCA1 also has a function in eliminating recombinationdefective oocytes. Brca1 k...
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作者：Gao, Luna; Ardiel, Evan; Nurrish, Stephen; Kaplan, Joshua M.
作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School
摘要：Type 1 voltage - activated calcium channels (CaV1) in the plasma membrane trigger calcium release from the sarcoplasmic reticulum (SR) by two mechanisms. In voltage - induced calcium release (VICR), CaV1 voltage sensing domains are directly coupled to ryanodine receptors (RYRs), an SR calcium channel. In calcium - induced calcium release (CICR), calcium ions flowing through activated CaV1 channels bind and activate RYR channels. VICR is thought to occur exclusively in vertebrate skeletal muscl...
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作者：Gilbert, Natasha
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作者：Teyssonniere, Elie Marcel; Trebulle, Pauline; Muenzner, Julia; Loegler, Victor; Ludwig, Daniela; Amari, Fatma; Muelleder, Michael; Friedrich, Anne; Hou, Jing; Ralser, Markus; Schacherer, Joseph
作者单位：Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Centre National de la Recherche Scientifique (CNRS); University of Oxford; Wellcome Centre for Human Genetics; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Max Planck Society; Institut Universitaire de France
摘要：Gene expression varies between individuals and corresponds to a key step linking genotypes to phenotypes. However, our knowledge regarding the species - wide genetic control of protein abundance, including its dependency on transcript levels, is very limited. Here, we have determined quantitative proteomes of a large population of 942 diverse natural Saccharomyces cerevisiae yeast isolates. We found that mRNA and protein abundances are weakly correlated at the population gene level. While the ...
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作者：Unwin, Nigel
作者单位：MRC Laboratory Molecular Biology; UK Research & Innovation (UKRI); Medical Research Council UK (MRC)
摘要：The muscle - type nicotinic acetylcholine receptor is a transmitter - gated ion channel residing in the plasma membrane of electrocytes and striated muscle cells. It is present predominantly at synaptic junctions, where it effects rapid depolarization of the postsynaptic membrane in response to acetylcholine released into the synaptic cleft. Previously, cryo - EM of intact membrane from Torpedo revealed that the lipid bilayer surrounding the junctional receptor has a uniquely asymmetric and or...
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作者：Visentin, Ivan; Ferigolo, Leticia Frizzo; Russo, Giulia; Krukowski, Paolo Korwin; Capezzali, Caterina; Tarkowska, Danuse; Gresta, Francesco; Deva, Eleonora; Nogueira, Fabio Tebaldi Silveira; Schubert, Andrea; Cardinale, Francesca
作者单位：University of Turin; Universidade de Sao Paulo; Palacky University Olomouc; Czech Academy of Sciences; Institute of Experimental Botany of the Czech Academy of Sciences; University of Milan
摘要：Strigolactones are a class of phytohormones with various functions in plant development, stress responses, and in the interaction with (micro)organisms in the rhizosphere. While their effects on vegetative development are well studied, little is known about their role in reproduction. We investigated the effects of genetic and chemical modification of strigolactone levels on the timing and intensity of flowering in tomato ( Solanum lycopersicum L.) and the molecular mechanisms underlying such ...
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作者：Li, Michael Y.; Chong, Lauren C.; Duns, Gerben; Lytle, Andrew; Woolcock, Bruce; Jiang, Aixiang; Telenius, Adele; Ben-Neriah, Susana; Nawaz, Waqas; Slack, Graham W.; Elisia, Ingrid; Vigano, Elena; Aoki, Tomohiro; Healy, Shannon; Krystal, Gerald; Venturutti, Leandro; Scott, David W.; Steidl, Christian
作者单位：University of British Columbia
摘要：Here, we report recurrent focal deletions of the chr14q32.31 - 32 locus, including TRAF3 , a negative regulator of NF -K B signaling, in de novo diffuse large B cell lymphoma (DLBCL) (24/324 cases). Integrative analysis revealed an association between TRAF3 copy number loss with accumulation of NIK, the central noncanonical (NC) NF -K B kinase, and increased NC NF -K B pathway activity. Accordingly, TRAF3 genetic ablation in isogenic DLBCL model systems caused upregulation of NIK and enhanced ...
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作者：Shu, Sheng; Tsutsui, Yuko; Nathawat, Rajkanwar; Mi, Wei
作者单位：Yale University; Yale University; Yale University
摘要：Levels of lipopolysaccharide (LPS), an essential glycolipid on the surface of most gramnegative bacteria, are tightly controlled-making LPS synthesis a promising target for developing new antibiotics. Escherichia coli adaptor protein LapB (YciM) plays an important role in regulating LPS synthesis by promoting degradation of LpxC, a deacetylase that catalyzes the first committed step in LPS synthesis. Under conditions where LPS is abundant, LapB recruits LpxC to the AAA+ protease FtsH for degra...
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作者：Wenzel, Arne; Westphal, Catrin; Ballauff, Johannes; Berkelmann, Dirk; Brambach, Fabian; Buchori, Damayanti; Camarretta, Nicolo; Corre, Marife D.; Daniel, Rolf; Darras, Kevin; Erasmi, Stefan; Formaglio, Greta; Hoelscher, Dirk; Iddris, Najeeb Al-Amin; Irawan, Bambang; Knohl, Alexander; Kotowska, Martyna M.; Krashevska, Valentyna; Kreft, Holger; Mulyani, Yeni; Musshoff, Oliver; Paterno, Gustavo B.; Polle, Andrea; Potapov, Anton; Roell, Alexander; Scheu, Stefan; Schlund, Michael; Schneider, Dominik; Sibhatu, Kibrom T.; Stiegler, Christian; Sundawati, Leti; Tjoa, Aiyen; Tscharntke, Teja; Veldkamp, Edzo; Waite, Pierre- Andre; Wollni, Meike; Zemp, Delphine Clara; Grass, Ingo
作者单位：University of Gottingen; University of Gottingen; University of Gottingen; University of Twente; University Hohenheim; Universidad Costa Rica; University of Gottingen; Bogor Agricultural University; University of Gottingen; University of Gottingen; Johann Heinrich von Thunen Institute; University of Gottingen; Universitas Jambi; University of Gottingen; University of Gottingen; Bogor Agricultural University; University of Gottingen; German Research Foundation (DFG); German Centre for Integrative Biodiversity Research (iDiv); Leipzig University; University of Gottingen; Bogor Agricultural University; Universitas Tadulako; University of Gottingen; Technische Universitat Dresden; University of Neuchatel; University Hohenheim
摘要：The expansion of the oil palm industry in Indonesia has improved livelihoods in rural communities, but comes at the cost of biodiversity and ecosystem degradation. Here, we investigated ways to balance ecological and economic outcomes of oil palm cultivation. We compared a wide range of production systems, including smallholder plantations, industrialized company estates, estates with improved agronomic management, and estates with native tree enrichment. Across all management types, we assess...
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作者：Rizo, Josep; Sari, Levent; Jaczynska, Klaudia; Rosenmund, Christian; Lin, Milo M.
作者单位：University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin
摘要：The SNAP receptor (SNARE) proteins syntaxin-1, SNAP - 25, and synaptobrevin mediate neurotransmitter release by forming tight SNARE complexes that fuse synaptic vesicles with the plasma membranes in microseconds. Membrane fusion is generally explained by the action of proteins on macroscopic membrane properties such as curvature, elastic modulus, and tension, and a widespread model envisions that the SNARE motifs, juxtamembrane linkers, and C- terminal transmembrane regions of synaptobrevin an...
