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作者：Lozano-Gomez, Daniel; Noculak, Vincent; Oitmaa, Jaan; Singh, Rajiv R. P.; Iqbal, Yasir; Reuther, Johannes; Gingras, Michel J. P.
作者单位：University of Waterloo; Technische Universitat Dresden; Technische Universitat Dresden; Free University of Berlin; Free University of Berlin; Helmholtz Association; Helmholtz-Zentrum fuer Materialien und Energie GmbH (HZB); University of New South Wales Sydney; University of California System; University of California Davis; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Madras; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Madras
摘要：Gauge theories are powerful theoretical physics tools that allow complex phenomena to be reduced to simple principles and are used in both high-energy and condensed matter physics. In the latter context, gauge theories are becoming increasingly popular for capturing the intricate spin correlations in spin liquids, exotic states of matter in which the dynamics of quantum spins never ceases, even at absolute zero temperature. We consider a spin system on a three-dimensional pyrochlore lattice wh...
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作者：Deneen, Benjamin
作者单位：Baylor College of Medicine; Baylor College Medical Hospital; Baylor College of Medicine; Baylor College of Medicine
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作者：Jackman, William R.; Portillo, Lyn S. Miranda; Cox, Carol K.; Ambrosio, Alison; Gibert, Yann
作者单位：Bowdoin College; University of Mississippi; University of Mississippi Medical Center; University of Mississippi Medical Center; University of Mississippi
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作者：Ji, Jie; Du, Shengli; Wang, Kun; Qi, Ziyan; Zhang, Chunyang; Wang, Rui; Bruening, George; Wang, Pengwei; Duanmu, Deqiang; Fan, Qiuling
作者单位：Huazhong Agricultural University; Huazhong Agricultural University; Huazhong Agricultural University; University of California System; University of California Davis
摘要：Many virus genomes encode proteases that facilitate infection. The molecular mechanism of plant recognition of viral proteases is largely unexplored. Using the system of Vigna unguiculata and cowpea mosaic virus (CPMV), we identified a cowpea lipid transfer protein (LTP1) which interacts with CPMV- encoded 24KPro, a cysteine protease, but not with the enzymatically inactive mutant 24KPro(C166A). Biochemical assays showed that LTP1 inhibited 24KPro proteolytic cleavage of the coat protein precu...
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作者：Pironon, Nathalie; Bourrat, Emmanuelle; Prost, Catherine; Chen, Mei; Woodley, David T.; Titeux, Matthias; Hovnanian, Alain
作者单位：Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Saint-Louis - APHP; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Saint-Louis - APHP; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Avicenne - APHP; Universite Paris 13; University of Southern California; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP
摘要：Recessive dystrophic epidermolysis bullosa (RDEB) is a rare and most often severe genetic disease characterized by recurrent blistering and erosions of the skin and mucous membranes after minor trauma, leading to major local and systemic complications. The disease is caused by loss-of-function variants in COL7A1 encoding type VII collagen (C7), the main component of anchoring fibrils, which form attachment structures stabilizing the cutaneous basement membrane zone. Alterations in C7 protein s...
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作者：Sun, Fei; Mishra, Simli; Stockert, Ulrike; Daou, Ramzy; Kikugawa, Naoki; Perry, Robin S.; Hassinger, Elena; Hartnoll, Sean A.; MacKenzie, Andrew P.; Sunko, Veronika
作者单位：Max Planck Society; Centre National de la Recherche Scientifique (CNRS); Universite de Caen Normandie; National Institute for Materials Science; University of London; University College London; University of London; University College London; UK Research & Innovation (UKRI); Science & Technology Facilities Council (STFC); STFC Rutherford Appleton Laboratory; University of Cambridge; University of St Andrews; University of California System; University of California Berkeley
摘要：In many physical situations in which many- body assemblies exist at temperature T , a characteristic quantum- mechanical time scale of approximately & hbar;/ k B T can be identified in both theory and experiment, leading to speculation that it may be the shortest meaningful time in such circumstances. This behavior can be investigated by probing the scattering rate of electrons in a broad class of materials often referred to as strongly correlated metals. It is clear that in some cases only el...
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作者：Dall, Natalie R.; Mendonca, Carolina A. T. F.; Vera, Hector L. Torres; Marqusee, Susan
作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley
摘要：Protein folding in the cell often begins during translation. Many proteins fold more efficiently cotranslationally than when refolding from a denatured state. Changing the vectorial synthesis of the polypeptide chain through circular permutation could impact functional, soluble protein expression and interactions with cellular proteostasis factors. Here, we measure the solubility and function of every possible circular permutant (CP) of HaloTag in Escherichia coli cell lysate using a gel- base...
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作者：Rumbaugh, Tristen D.; Gorka, Michael J.; Baker, Carol S.; Golbeck, John H.; Silakov, Alexey
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park
摘要：The fusion of hydrogenases and photosynthetic reaction centers (RCs) has proven to be a promising strategy for the production of sustainable biofuels. Type I (iron- sulfur- containing) RCs, acting as photosensitizers, are capable of promoting electrons to a redox state that can be exploited by hydrogenases for the reduction of protons to dihydrogen (H2). While both [FeFe] and [NiFe] hydrogenases have been used successfully, they tend to be limited due to either O2 sensitivity, binding specific...
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作者：Shimanovich, Ulyana; Hartl, F. Ulrich
作者单位：Weizmann Institute of Science; Max Planck Society
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作者：Zink, Anna; Obermeyer, Ziad; Pierson, Emma
作者单位：University of Chicago; University of California System; University of California Berkeley; Cornell University; Weill Cornell Medicine
摘要：Despite ethical and historical arguments for removing race from clinical algorithms, the consequences of removal remain unclear. Here, we highlight a largely undiscussed consideration in this debate: varying data quality of input features across race groups. For example, family history of cancer is an essential predictor in cancer risk prediction algorithms but is less reliably documented for Black participants and may therefore be less predictive of cancer outcomes. Using data from the Southe...
