2024

最新文章

• An encompassed representation of timescale hierarchies in first-order reaction network AI翻译
  作者：Nagahata, Yutaka; Kobayashi, Masato; Toda, Mikito; Maeda, Satoshi; Taketsugu, Tetsuya; Komatsuzaki, Tamiki
  作者单位：Hokkaido University; Hokkaido University; Hokkaido University; Nara Womens University; University of Hyogo; University of Osaka; University of Osaka
  摘要：Complex networks are pervasive in various fields such as chemistry, biology, and sociology. In chemistry, first-order reaction networks are represented by a set of first-order differential equations, which can be constructed from the underlying energy landscape. However, as the number of nodes increases, it becomes more challenging to understand complex kinetics across different timescales. Hence, how to construct an interpretable, coarse-graining scheme that preserves the underlying timescale...
• Large Fermi surface in pristine kagome metal CsV3Sb5 and enhanced quasiparticle effective masses AI翻译
  作者：Zhang, Wei; Poon, Tsz Fung; Tsang, Chun Wai; Wang, Wenyan; Liu, X.; Xie, J.; Lam, S. T.; Wang, Shanmin; Lai, Kwing To; Pourret, A.; Seyfarth, G.; Knebel, G.; Yu, Wing Chi; Goh, Swee K.
  作者单位：Chinese University of Hong Kong; Southern University of Science & Technology; Chinese University of Hong Kong; CUHK Shenzhen Research Institute; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Institut National Polytechnique de Grenoble; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Universite de Toulouse; Universite Toulouse III - Paul Sabatier; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Universite Federale Toulouse Midi-Pyrenees (ComUE); Institut National des Sciences Appliquees de Toulouse; Centre National de la Recherche Scientifique (CNRS); City University of Hong Kong
  摘要：The kagome metal CsV3Sb5 is an ideal platform to study the interplay between topology and electron correlation. To understand the fermiology of CsV3Sb5, intensive quantum oscillation (QO) studies at ambient pressure have been conducted. However, due to the Fermi surface reconstruction by the complicated charge density wave (CDW) order, the QO spectrum is exceedingly complex, hindering a complete understanding of the fermiology. Here, we directly map the Fermi surface of the pristine CsV3Sb5 by...
• ZEPPI: Proteome- scale sequence- based evaluation of protein- protein interaction models AI翻译
  作者：Zhao, Haiqing; Petrey, Donald; Murray, Diana; Honig, Barry
  作者单位：NewYork-Presbyterian Hospital; Columbia University; NewYork-Presbyterian Hospital; Columbia University; Columbia University; Columbia University
  摘要：We introduce ZEPPI (Z - score Evaluation of Protein-Protein Interfaces), a framework to evaluate structural models of a complex based on sequence coevolution and conservation involving residues in protein-protein interfaces. The ZEPPI score is calculated by comparing metrics for an interface to those obtained from randomly chosen residues. Since contacting residues are defined by the structural model, this obviates the need to account for indirect interactions. Further, although ZEPPI relies o...
• Hidden hotspots of amphibian biodiversity in China AI翻译
  作者：Xu, Wei; Wu, Yun-He; Zhou, Wei-Wei; Chen, Hong-Man; Zhang, Bao-Lin; Chen, Jin-Min; Xu, Weihua; Rao, Ding-Qi; Zhao, Haipeng; Yan, Fang; Yuan, Zhiyong; Jiang, Ke; Jin, Jie-Qiong; Hou, Mian; Zou, Dahu; Wang, Li-Jun; Zheng, Yuchi; Li, Jia-Tang; Jiang, Jianping; Zeng, Xiao-Mao; Chen, Youhua; Liao, Zi-Yan; Li, Cheng; Li, Xue-You; Gao, Wei; Wang, Kai; Zhang, Dong-Ru; Lu, Chenqi; Yin, Tingting; Ding, Zhaoli; Zhao, Gui-Gang; Cha, Jing; Zhang, Wen-Ge; Zhang, Ya-Ping; Wieng, John J.; Che, Jing
  作者单位：Chinese Academy of Sciences; Kunming Institute of Zoology, CAS; Chinese Academy of Sciences; Research Center for Eco-Environmental Sciences (RCEES), CAS; Henan University; Sichuan Normal University; Xizang University; Hainan Normal University; Chinese Academy of Sciences; Chengdu Institute of Biology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Yunnan University; University of Arizona
  摘要：Identifying and protecting hotspots of endemism and species richness is crucial for mitigating the global biodiversity crisis. However, our understanding of spatial diversity patterns is far from complete, which severely limits our ability to conserve biodiversity hotspots. Here, we report a comprehensive analysis of amphibian species diversity in China, one of the most species - rich countries on Earth. Our study combines 20 y of field surveys with new molecular analyses of 521 described spec...
• Class IIa HDAC4 and HDAC7 cooperatively regulate gene transcription in Th17 cell differentiation AI翻译
  作者：Cheung, Ka Lung; Zhao, Li; Sharma, Rajal; Ghosh, Anurupa Abhijit; Appiah, Michael; Sun, Yifei; Jaganathan, Anbalagan; Hu, Yuan; Lejeune, Alannah; Xu, Feihong; Han, Xinye; Wang, Xueting; Zhang, Fan; Ren, Chunyan; Walsh, Martin J.; Xiong, Huabao; Tsankov, Alexander; Zhou, Ming-Ming
  作者单位：Icahn School of Medicine at Mount Sinai; Jilin University; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai
  摘要：Class II histone deacetylases (HDACs) are important in regulation of gene transcription during T cell development. However, our understanding of their cell - specific functions is limited. In this study, we reveal that class IIa Hdac4 and Hdac7 (Hdac4/7) are selectively induced in transcription, guiding the lineage - specific differentiation of mouse T - helper 17 (Th17) cells from naive CD4 + T cells. Importantly, Hdac4/7 are functionally dispensable in other Th subtypes. Mechanistically, Hda...
• The nonexistence of a paddlewheel effect in superionic conductors AI翻译
  作者：Jun, Kyujung; Lee, Byungju; Kam, Ronald L.; Ceder, Gerbrand
  作者单位：University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Korea Institute of Science & Technology (KIST)
  摘要：Since the 1980s, the paddlewheel effect has been suggested as a mechanism to boost lithium- ion diffusion in inorganic materials via the rotation of rotor- like anion groups. However, it remains unclear whether the paddlewheel effect, defined as large- angle anion group rotations assisting Li hopping, indeed exists; furthermore, the physical mechanism by which the anion- group dynamics affect lithium- ion diffusion has not yet been established. In this work, we differentiate various types of r...
• Functional specialization of hippocampal somatostatin- expressing interneurons AI翻译
  作者：Chamberland, Simon; Grant, Gariel; Machold, Robert; Nebet, Erica R.; Tian, Guoling; Stich, Joshua; Hanani, Monica; Kullander, Klas; Tsien, Richard W.
  作者单位：New York University; New York University; Uppsala University; New York University
  摘要：Hippocampal somatostatinexpressing ( Sst ) GABAergic interneurons (INs) exhibit considerable anatomical and functional heterogeneity. Recent single - cell transcriptome analyses have provided a comprehensive Sst - IN subpopulations census, a plausible molecular ground truth of neuronal identity whose links to specific functionality remain incomplete. Here, we designed an approach to identify and access subpopulations of Sst - INs based on transcriptomic features. Four mouse models based on sin...
• Differential nanoscale organization of excitatory synapses onto excitatory vs. inhibitory neurons AI翻译
  作者：Dharmasri, Poorna A.; Levy, Aaron D.; Blanpied, Thomas A.
  作者单位：University System of Maryland; University of Maryland Baltimore; University System of Maryland; University of Maryland Baltimore; University System of Maryland; University of Maryland Baltimore
  摘要：A key feature of excitatory synapses is the existence of subsynaptic protein nanoclusters (NCs) whose precise alignment across the cleft in a transsynaptic nanocolumn influences the strength of synaptic transmission. However, whether nanocolumn properties vary between excitatory synapses functioning in different cellular contexts is unknown. We used a combination of confocal and DNA - PAINT super - resolution microscopy to directly compare the organization of shared scaffold proteins at two im...
• Identification of an active RNAi pathway in Candida albicans AI翻译
  作者：Iracane, Elise; Arias-Sarda, Cristina; Maufrais, Corinne; V. Ene, Iuliana; d'Enfert, Christophe; Buscaino, Alessia
  作者单位：University of Kent; Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; INRAE
  摘要：RNA interference (RNAi) is a fundamental regulatory pathway with a wide range of functions, including regulation of gene expression and maintenance of genome stability. Although RNAi is widespread in the fungal kingdom, well - known species, such as the model yeast Saccharomyces cerevisiae , have lost the RNAi pathway. Until now evidence has been lacking for a fully functional RNAi pathway in Candida albicans , a human fungal pathogen considered critically important by the World Health Organiz...
• Substantial transmission of SARS- CoV-2 through casual contact in retail stores: Evidence from matched administrative microdata on card payments and testing AI翻译
  作者：Johannesen, Niels; Martinello, Alessandro Tang- Andersen; Vestergaard, Emil Toft; Andersen, Asger Lau; Jensen, Thais Laerkholm
  作者单位：University of Oxford; University of Copenhagen; University of Copenhagen
  摘要：This paper presents quasiexperimental evidence of Covid - 19 transmission through casual contact between customers in retail stores. For a large sample of individuals in Denmark, we match card payment data, indicating exactly where and when each individual made purchases, with Covid - 19 test data, indicating when each individual was tested and whether the test was positive. The resulting dataset identifies more than 100,000 instances where an infected individual made a purchase in a store and...