3期

最新文章

• ADARp110 promotes hepatocellular carcinoma progression via stabilization of CD24 mRNA AI翻译
  作者：Sun, Liangzhan; Hu, Pengchao; Yang, Hui; Ren, Jun; Hu, Rong; Wu, Shasha; Wang, Yanchen; Du, Yuyang; Zheng, Jingyi; Wang, Fenfen; Gao, Han; Yan, Jingsong; Yuan, Yun-Fei; Guan, Xin-Yuan; Xiao, Jia; Li, Yan
  作者单位：Southern University of Science & Technology; University of Hong Kong; University of Hong Kong; Shenzhen Bay Laboratory; Peking University Shenzhen Graduate School (PKU Shenzhen); Peking University; Hubei University of Medicine; Southern Medical University - China; State Key Lab Oncology South China; Sun Yat Sen University; Jinan University
  摘要：ADAR is highly expressed and correlated with poor prognosis in hepatocellular carcinoma (HCC), yet the role of its constitutive isoform ADARp110 in tumorigenesis remains elusive. We investigated the role of ADARp110 in HCC and underlying mechanisms using clinical samples, a hepatocyte- specificAdarp110 knock- in mouse model, and engineered cell lines. ADARp110 is overexpressed and associated with poor survival in both human and mouse HCC. It creates an immunosuppressive microenvironment by inh...
• Visual pigments underlie the sensitivity difference between day and night vision AI翻译
  作者：Ala-Laurila, Petri
  作者单位：University of Helsinki; Aalto University
• Glyphosate exposure and GM seed rollout unequally reduced perinatal health AI翻译
  作者：Reynier, Emmett; Rubin, Edward
  作者单位：University of Oregon; United States Environmental Protection Agency; Oak Ridge Associated Universities; United States Department of Energy (DOE); Oak Ridge Institute for Science & Education
  摘要：The advent of herbicide-tolerant genetically modified (GM) crops spurred rapid and widespread use of the herbicide glyphosate throughout US agriculture. In the two decades following GM-seeds' introduction, the volume of glyphosate applied in the United States increased by more than 750%. Despite this breadth and scale, science and policy remain unresolved regarding the effects of glyphosate on human health. We identify the causal effect of glyphosate exposure on perinatal health by combining 1...
• Precision data-driven modeling of cortical dynamics reveals person-specific mechanisms underpinning brain electrophysiology AI翻译
  作者：Singh, Matthew F.; Braver, Todd S.; Cole, Michael; Ching, Shinung
  作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; Washington University (WUSTL); Washington University (WUSTL); Rutgers University System; Rutgers University Newark; Rutgers University New Brunswick
  摘要：Task-free brain activity affords unique insight into the functional structure of brain network dynamics and has been used to identify neural markers of individual differences. In this work, we present an algorithmic optimization framework that directly inverts and parameterizes brain-wide dynamical-systems models involving hundreds of interacting neural populations, from single-subject M/EEG timeseries recordings. This technique provides a powerful neurocomputational tool for interrogating mec...
• Transcriptional drift in aging cells: A global decontroller (vol 121, e2401830121, 2024) AI翻译
  作者：[Anonymous]
• Pan- European atmospheric lead pollution, enhanced blood lead levels, and cognitive decline from Roman- era mining and smelting AI翻译
  作者：Mcconnell, Joseph R.; Chellman, Nathan J.; Plach, Andreas; Wensman, Sophia M.; Plunkett, Gill; Stohl, Andreas; Smith, Nicole-Kristine; Vinther, Bo Mollesoe; Dahl-Jensen, Dorthe; Steffensen, Jorgen Peder; Fritzsche, Diedrich; Camara-Brugger, Sandra O.; Mcdonald, Brandon T.; Wilson, Andrew I.
  作者单位：Nevada System of Higher Education (NSHE); Desert Research Institute NSHE; University of Vienna; Queens University Belfast; Yale University; University of Copenhagen; Niels Bohr Institute; University of Manitoba; Helmholtz Association; Alfred Wegener Institute, Helmholtz Centre for Polar & Marine Research; University of Basel; Tufts University; University of Oxford; University of Oxford
  摘要：Ancient texts and archaeological evidence indicate substantial lead exposure during antiquity that potentially impacted human health. Although lead exposure routes were many and included the use of glazed tablewares, paints, cosmetics, and even intentional ingestion, the most significant for the nonelite, rural majority of the population may have been through background air pollution from mining and smelting of silver and lead ores that underpinned the Roman economy. Here, we determined potent...
• Spatially programmed alignment and actuation in printed liquid crystal elastomers AI翻译
  作者：Telles, Rodrigo; Kotikian, Arda; Freychet, Guillaume; Zhernenkov, Mikhail; Wasik, Patryk; Yavitt, Benjamin M.; Barrera, Jorge-Luis; Cook, Caitlyn C.; Pindak, Ronald; Davidson, Emily C.; Lewis, Jennifer A.
  作者单位：Harvard University; Harvard University; United States Department of Energy (DOE); Brookhaven National Laboratory; United States Department of Energy (DOE); Lawrence Livermore National Laboratory; Princeton University; CEA; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); University System of Ohio; University of Cincinnati
  摘要：Liquid crystal elastomers (LCEs) exhibit reversible shape morphing behavior when cycled above their nematic- to- isotropic transition temperature. During extrusion- based 3D printing, LCE inks are subjected to coupled shear and extensional flows that can be harnessed to spatially control the alignment of their nematic director along prescribed print paths. Here, we combine experiment and modeling to elucidate the effects of ink composition, nozzle geometry, and printing parameters on director ...
• A solution to the pervasive problem of response bias in self-reports AI翻译
  作者：Grimmond, Jess; Brown, Scott D.; Hawkins, Guy E.
  作者单位：University of Newcastle
  摘要：Self-reports are used ubiquitously to probe people's thoughts, feelings, and behaviors and inform medical decisions, enterprise operations, and government policy and legislation. Despite their pervasive use, self-report measures such as Likert scales have a profound problem: Standard analytic approaches do not control for the confounding effects of idiosyncratic response biases. Here, we present a model-based solution to this problem. Our model disentangles response bias from latent constructs...
• Burrow collapse is not the only explanation for rapid, noncatastrophic preservation of 3D dinosaurs AI翻译
  作者：Wetherell, Meaghan M. Emery-
  作者单位：University of Arizona
• An evolutionarily conserved cation channel tunes the sensitivity of gustatory neurons to ephaptic inhibition in Drosophila AI翻译
  作者：Lee, Minhyuk; Kim, Seon Yeong; Park, Taeim; Yoon, Sung-Eun; Kim, Young-Joon; Joo, Kyeung Min; Kwon, Jae Young; Kim, Kyuhyung; Kang, Kyeongjin
  作者单位：Korea Brain Research Institute (KBRI); Sungkyunkwan University (SKKU); Samsung Medical Center; Sungkyunkwan University (SKKU); Daegu Gyeongbuk Institute of Science & Technology (DGIST); Gwangju Institute of Science & Technology (GIST)
  摘要：In ephaptic coupling, physically adjacent neurons influence one another's activity via the electric fields they generate. To date, the molecular mechanisms that mediate and modulate ephaptic coupling's effects remain poorly understood. Here, we show that the hyperpolarization-activated cyclic nucleotide-gated (HCN) channel lateralizes the potentially mutual ephaptic inhibition between Drosophila gustatory receptor neurons (GRNs). While sweet-sensing GRNs (sGRNs) engage in ephaptic suppression ...