3期

最新文章

• Structural determinants of oxygen resistance and Zn2+- mediated stability of the [FeFe]- hydrogenase from Clostridium beijerinckii AI翻译
  作者：Duan, Jifu; Rutz, Andreas; Kawamoto, Akihiro; Naskar, Shuvankar; Edenharter, Kristina; Leimkuehler, Silke; Hofmann, Eckhard; Happe, Thomas; Kurisu, Genji
  作者单位：Ruhr University Bochum; University of Osaka; University of Potsdam; Ruhr University Bochum
  摘要：[FeFe]- hydrogenases catalyze the reversible two- electron reduction of two protons to molecular hydrogen. Although these enzymes are among the most efficient H2- converting biocatalysts in nature, their catalytic cofactor (termed H- cluster) is irreversibly destroyed upon contact with dioxygen. The [FeFe]- hydrogenase CbA5H from Clostridium beijerinckii has a unique mechanism to protect the H- cluster from oxygen- induced degradation. The protective strategy of CbA5H was proposed based on a p...
• Reply to Emery- Wetherell: Taphonomy of Lujiatun 3D dinosaurs is inconsistent with death and burial by lahars AI翻译
  作者：Olsen, Paul E.; Maclennan, Scott A.; Sha, Jingeng; Kinney, Sean T.; Chang, Clara; Fang, Yanan; Liu, Jun; Slibeck, Bennett B.; Chen, Elaine; Schoene, Blair
  作者单位：Columbia University; University of Witwatersrand; Princeton University; Chinese Academy of Sciences; Rutgers University System; Rutgers University New Brunswick; Chinese Academy of Sciences; Institute of Vertebrate Paleontology & Paleoanthropology, CAS
• Fungal evasion of Drosophila immunity involves blocking the cathepsin- mediated cleavage maturation of the danger- sensing protease AI翻译
  作者：Tang, Guirong; Song, Shuangxiu; Shang, Junmei; Luo, Yujuan; Li, Shiqin; Wei, Dongxiang; Wang, Chengshu
  作者单位：Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS; Shanghai Academy of Agricultural Sciences; ShanghaiTech University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
  摘要：Entomopathogenic fungi play a critical role in regulating insect populations, and representative species from the Metarhizium and Beauveria genera have been developed as eco- friendly biocontrol agents for managing agricultural insect pests. Relative to the advances in understanding antifungal immune responses in Drosophila, knowledge of how fungi evade insect immune defenses remains limited. In this study, we report the identification and characterization of a virulence- required effector Fkp...
• Dual modes of DNA N6-methyladenine maintenance by distinct methyltransferase complexes AI翻译
  作者：Wang, Yuanyuan; Nan, Bei; Ye, Fei; Zhang, Zhe; Yang, Wentao; Pan, Bo; Wei, Fan; Duan, Lili; Li, Haicheng; Niu, Junhua; Ju, Aili; Liu, Yongqiang; Wang, Dantong; Zhang, Wenxin; Liu, Yifan; Gao, Shan
  作者单位：Ocean University of China; Ocean University of China; University of Southern California; Yunnan University
  摘要：Stable inheritance of DNA N6- methyladenine (6mA) is crucial for its biological functions in eukaryotes. Here, we identify two distinct methyltransferase (MTase) complexes, both sharing the catalytic subunit AMT1, but featuring AMT6 and AMT7 as their unique components, respectively. While the two complexes are jointly responsible for 6mA maintenance methylation, they exhibit distinct enzymology, DNA/chromatin affinity, genomic distribution, and knockout phenotypes. AMT7 complex, featuring high...
• Tubulin detyrosination shapes Leishmania cytoskeletal architecture and virulence AI翻译
  作者：Corrales, Rosa Milagros; Vincent, Jeremy; Crobu, Lucien; Neish, Rachel; Nepal, Binita; Espeut, Julien; Pasquier, Gregoire; Gillard, Ghislain; Cazevieille, Chantal; Mottram, Jeremy C.; Wetzel, Dawn M.; Sterkers, Yvon; Rogowski, Krzysztof; Leveque, Maude F.
  作者单位：Institut de Recherche pour le Developpement (IRD); Centre National de la Recherche Scientifique (CNRS); Universite de Montpellier; University of York - UK; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; Universite de Montpellier; Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite de Montpellier
  摘要：Tubulin detyrosination has been implicated in various human disorders and is important for regulating microtubule dynamics. While in most organisms this modification is restricted to alpha-tubulin, in trypanosomatid parasites, it occurs on both alpha- and beta-tubulin. Here, we show that in Leishmania, a single vasohibin (LmVASH) enzyme is responsible for differential kinetics of alpha- and beta-tubulin detyrosination. LmVASH knockout parasites, which are completely devoid of detyrosination, s...
• Specialization of the human hippocampal long axis revisited AI翻译
  作者：Angeli, Peter A.; Dinicola, Lauren M.; Saadon-Grosman, Noam; Eldaief, Mark C.; Buckner, Randy L.
  作者单位：Harvard University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital
  摘要：The hippocampus possesses anatomical differences along its long axis. Here, we explored the functional specialization of the human hippocampal long axis using network- anchored precision functional MRI in two independent datasets (N = 11 and N = 9) paired with behavioral analysis (N = 266 and N = 238). Functional connectivity analyses demonstrated that the anterior hippocampus was preferentially correlated with a cerebral network associated with remembering, while the posterior hippocampus sel...
• High organofluorine concentrations in municipal wastewater affect downstream drinking water supplies for millions of Americans AI翻译
  作者：Ruyle, Bridger J.; Pennoyer, Emily H.; Vojta, Simon; Becanova, Jitka; Islam, Minhazul; Webster, Thomas F.; Bernays, Wendy Heiger-; Lohmann, Rainer; Westerhoff, Paul; Schaefer, Charles E.; Sunderland, Elsie M.
  作者单位：Harvard University; Carnegie Institution for Science; New York University; New York University Tandon School of Engineering; Boston University; University of Rhode Island; Arizona State University; Arizona State University-Tempe; Harvard University; Harvard University; Harvard T.H. Chan School of Public Health
  摘要：Wastewater receives per- and polyfluoroalkyl substances (PFAS) from diverse consumer and industrial sources, and discharges are known to be a concern for drinking water quality. The PFAS family includes thousands of potential chemical structures containing organofluorine moieties. Exposures to a few well- studied PFAS, mainly perfluoroalkyl acids (PFAA), have been associated with increased risk of many adverse health outcomes, prompting federal drinking water regulations for six compounds in 2...
• Profile of Yosef Shiloh AI翻译
  作者：Viegas, Jennifer
  作者单位：Tel Aviv University
• Codon bias, nucleotide selection, and genome size predict in situ bacterial growth rate and transcription in rewetted soil AI翻译
  作者：Chuckran, Peter F.; Estera-Molina, Katerina; Nicolas, Alexa M.; Sieradzki, Ella T.; Dijkstra, Paul; Firestone, Mary K.; Pett-Ridge, Jennifer; Blazewicz, Steven J.
  作者单位：University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Livermore National Laboratory; University of California System; University of California Berkeley; Columbia University; Universite Claude Bernard Lyon 1; Institut National des Sciences Appliquees de Lyon - INSA Lyon; Ecole Centrale de Lyon; Northern Arizona University; University of California System; University of California Merced; University of California System; University of California Berkeley
  摘要：In soils, the first rain after a prolonged dry period represents a major pulse event impacting soil microbial community function, yet we lack a full understanding of the genomic traits associated with the microbial response to rewetting. Genomic traits such as codon usage bias and genome size have been linked to bacterial growth in soils-however, often through measurements in culture. Here, we used metagenome-assembled genomes (MAGs) with O-18-water stable isotope probing and metatranscriptomi...
• Estimating realized relatedness in free- ranging macaques by inferring identity- by- descent segments AI翻译
  作者：Freudiger, Annika; Jovanovic, Vladimir M.; Huang, Yilei; Snyder- Mackler, Noah; Conrad, Donald F.; Miller, Brian; Montague, Michael J.; Westphal, Hendrikje; Stadler, Peter F.; Bley, Stefanie; Horvath, Julie E.; Brent, Lauren J. N.; Platt, Michael L.; Ruiz-Lambides, Angelina; Tung, Jenny; Nowick, Katja; Ringbauer, Harald; Widdig, Anja
  作者单位：Leipzig University; Max Planck Society; Free University of Berlin; Max Planck Society; Leipzig University; Leipzig University; Arizona State University; Arizona State University-Tempe; Oregon Health & Science University; Oregon National Primate Research Center; University of Pennsylvania; Max Planck Society; University of Vienna; Universidad Nacional de Colombia; The Santa Fe Institute; North Carolina State University; University of North Carolina; University of North Carolina Chapel Hill; University of Exeter; University of Pennsylvania; University of Pennsylvania; Duke University; Duke University; Duke University; German Research Foundation (DFG); German Centre for Integrative Biodiversity Research (iDiv)
  摘要：Biological relatedness is a key consideration in studies of behavior, population structure, and trait evolution. Except for parent-offspring dyads, pedigrees capture relatedness imperfectly. The number and length of identical- by- descent DNA segments (IBD) yield the most precise relatedness estimates. Here, we leverage different methods for estimating IBD segments from low- depth whole genome resequencing data to demonstrate the fea-sibility and value of resolving fine- scaled gradients of re...