3期

最新文章

• A paradoxical misperception of relative motion (vol 121, e2410755121, 2024) AI翻译
  作者：D'Angelo, Josephine C.; Tiruveedhula, Pavan; Weber, Raymond J.; Arathorn, David W.; Roorda, Austin
• Arctic soil carbon insulation averts large spring cooling from surface-atmosphere feedbacks AI翻译
  作者：Gaillard, Remi; Peylin, Philippe; Cadule, Patricia; Bastrikov, Vladislav; Cheruy, Frederique; Cuynet, Amelie; Ghattas, Josefine; Zhu, Dan; Guenet, Bertrand
  作者单位：Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Earth Sciences & Astronomy (INSU); Universite PSL; Ecole Normale Superieure (ENS); Universite Paris Saclay; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); Universite PSL; Ecole Normale Superieure (ENS); Sorbonne Universite; Institut Polytechnique de Paris; Ecole Polytechnique; Universite Paris Saclay; Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Earth Sciences & Astronomy (INSU); Peking University
  摘要：The insulative properties of soil organic carbon (SOC) and surface organic layers (moss, lichens, litter) regulate surface-atmosphere energy exchanges in the Arctic through a coupling with soil temperatures. However, a physical description of this process is lacking in many climate models, potentially biasing their high-latitude climate predictions. Using a coupled surface-atmosphere model, we identified a strong feedback loop between soil insulation, surface air temperature, and snowfall. Wit...
• Stimulating the regenerative capacity of the human retina with proneural transcription factors in 3D cultures AI翻译
  作者：Wohlschlegel, Juliette; Kierney, Faith; Arakelian, Kayla L.; Luxardi, Guillaume; Suvarnpradip, Naran; Hoffer, Dawn; Rieke, Fred; Moshiri, Ala; Reh, Thomas A.
  作者单位：University of Washington; University of Washington Seattle; University of California System; University of California Davis; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle
  摘要：Retinal diseases often lead to degeneration of specific retinal cell types with currently limited therapeutic options to replace the lost neurons. Previous studies have reported that overexpression of ASCL1 or combinations of proneural factors in M & uuml;ller glia (MG) induce regeneration of functional neurons in the adult mouse retina. Recently, we applied the same strategy in dissociated cultures of fetal human MG and although we stimulated neurogenesis from MG, our effect in 2D cultures wa...
• Crucial role of the cGAS N terminus in mediating flowable and functional cGAS-DNA condensate formation via DNA interactions AI翻译
  作者：Jiang, Zhelin; Shi, Fan; Li, Juan; Liu, Rui; Zhou, Jinhua; Zhong, Zhensheng; Shi, Chaowei; Ma, Mingming; Xiang, Shengqi; Gao, Daxing
  作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Anhui Medical University; Anhui Medical University; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS
  摘要：The DNA- sensing protein cGAS plays a pivotal role in the innate immune response and pathogenesis of various diseases. DNA triggers liquid-liquid phase separation (LLPS) and enhances the enzymatic activity of cGAS. However, the regulatory mechanisms of the disordered N terminus remain unclear. Here, we showed that cGASNterm, the N- terminal intrinsic disordered region (IDR) of cGAS, modulates the material properties, specifically the flowability, of the condensed phase of cGAS and is required ...
• Shifting equilibria in a warming boreal forest AI翻译
  作者：Magney, Troy S.; Pierrat, Zoe A.
  作者单位：University of California System; University of California Davis; California Institute of Technology; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL)
• Spatially programmed alignment and actuation in printed liquid crystal elastomers AI翻译
  作者：Telles, Rodrigo; Kotikian, Arda; Freychet, Guillaume; Zhernenkov, Mikhail; Wasik, Patryk; Yavitt, Benjamin M.; Barrera, Jorge-Luis; Cook, Caitlyn C.; Pindak, Ronald; Davidson, Emily C.; Lewis, Jennifer A.
  作者单位：Harvard University; Harvard University; United States Department of Energy (DOE); Brookhaven National Laboratory; United States Department of Energy (DOE); Lawrence Livermore National Laboratory; Princeton University; CEA; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); University System of Ohio; University of Cincinnati
  摘要：Liquid crystal elastomers (LCEs) exhibit reversible shape morphing behavior when cycled above their nematic-to- isotropic transition temperature. During extrusion- based 3D printing, LCE inks are subjected to coupled shear and extensional flows that can be harnessed to spatially control the alignment of their nematic director along prescribed print paths. Here, we combine experiment and modeling to elucidate the effects of ink composition, nozzle geometry, and printing parameters on director a...
• The population dynamics of clustered consumer-resource spatial patterns: Insights from the demographics of a Turing mechanism AI翻译
  作者：Hajian-Forooshani, Zachary; Rivera-Salinas, Iris Saraeny; Perfecto, Ivette; Vandermeer, John
  作者单位：University of Michigan System; University of Michigan; German Research Foundation (DFG); German Centre for Integrative Biodiversity Research (iDiv); Martin Luther University Halle Wittenberg; University of Michigan System; University of Michigan
  摘要：In ecology, Alan Turing's proposed activation-inhibition mechanism has been abstracted as corresponding to several ecological interaction types to explain pattern formation ecosystems. Consumer-resource interactions have strong theoretical arguments linking them to both the Turing mechanism and pattern formation, but there is little empirical support to demonstrate these claims. Here, we connect several lines of evidence to support the proposition that consumer-resource interactions can create...
• CFTR dictates monocyte adhesion by facilitating integrin clustering but not activation AI翻译
  作者：Younis, Doulathunnisa Ahamed; Marosvari, Mason; Liu, Wei; Pulikkot, Sunitha; Cao, Ziming; Zhou, Beiyan; Vella, Anthony T.; Mcardle, Sara; Hu, Liang; Chen, Yunfeng; Gan, Wenqi; Yu, Ji; Bruscia, Emanuela M.; Fan, Zhichao
  作者单位：La Jolla Institute for Immunology; Shanghai University of Traditional Chinese Medicine; University of Texas System; University of Texas Medical Branch Galveston; University of Texas System; University of Texas Medical Branch Galveston; Yale University
  摘要：Monocytes are critical in controlling tissue infections and inflammation. Monocyte dysfunction contributes to the inflammatory pathogenesis of cystic fibrosis (CF) caused cally relevant disease model for studying the contribution of monocytes to inflammation. Although CF monocytes exhibited adhesion defects, the precise mechanism is unclear. Herein, superresolution microscopy showed that an integrin clustering but not an integrin activation defect determines the adhesion defect in CFTR- defici...
• The androgen clock is an epigenetic predictor of long- term male hormone exposure AI翻译
  作者：Sugrue, Victoria J.; Prescott, Melanie; Glendining, Kelly A.; Bond, Donna M.; Horvath, Steve; Anderson, Greg M.; Garratt, Michael; Campbell, Rebecca E.; Hore, Timothy A.
  作者单位：University of Otago; University of Otago; University of California System; University of California Los Angeles
  摘要：Aging is a complex process characterized by biological decline and a wide range of molecular alterations to cells, including changes to DNA methylation. In this study, we used a male- specific epigenetic marker of aging to build an epigenetic predictor that measures long- term androgen exposure in sheep and mice (median absolute error of 4.3 and 1.4 mo, respectively). We term this predictor the androgen clock and show its tick is mediated by the androgen receptor and can be accelerated beyond ...
• Exercise intensity and training alter the innate immune cell type and chromosomal origins of circulating cell- free DNA in humans AI翻译
  作者：Rodrigues, Kameron B.; Weng, Ziming; Graham, Zachary A.; Lavin, Kaleen; Mcadam, Jeremy; Tuggle, S. Craig; Peoples, Brandon; Seay, Regina; Yang, Sufen; Bamman, Marcas M.; Broderick, Timothy J.; Montgomery, Stephen B.
  作者单位：Stanford University; Florida Institute for Human & Machine Cognition (IHMC); University of Alabama System; University of Alabama Birmingham
  摘要：Exercising regularly promotes health, but these benefits are complicated by acute inflammation induced by exercise. A potential source of inflammation is cell- free DNA (cfDNA), yet the cellular origins, molecular causes, and immune system interactions of exercise- induced cfDNA are unclear. To study these, 10 healthy individuals were randomized to a 12- wk exercise program of either high- intensity tactical training (HITT) or traditional moderate- intensity training (TRAD). Blood plasma was c...