9期

最新文章

• Ancient ocean coastal deposits imaged on Mars AI翻译
  作者：Li, Jianhui; Liu, Hai; Meng, Xu; Duan, Diwen; Lu, Haijing; Zhang, Jinhai; Zhang, Fengshou; Elsworth, Derek; Cardenas, Benjamin T.; Manga, Michael; Zhou, Bin; Fang, Guangyou
  作者单位：Guangzhou University; Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Geology & Geophysics, CAS; Tongji University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; University of California System; University of California Berkeley; Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Aerospace Information Research Institute, CAS
  摘要：The northern lowlands of early Mars could have contained a significant quantity of liquid water. However, the ocean hypothesis remains controversial due to the lack of conclusive evidence from the Martian subsurface. We use data from the Zhurong Rover Penetrating Radar on the southern Utopia Planitia to identify subsurface dipping reflectors indicative of an ancient prograding shoreline. The reflectors dip unidirectionally with inclinations in the range 6 degrees to 20 degrees and are imaged t...
• Limited and biased global conservation funding means most threatened species remain unsupported AI翻译
  作者：Guenard, Benoit; Hughes, Alice C.; Laine, Claudianne; Cannicci, Stefano; Russell, Bayden D.; Williams, Gray A.
  作者单位：University of Hong Kong; University of Florence; University of Hong Kong; University of Hong Kong
  摘要：The conservation of biodiversity represents a global challenge as the world experiences its sixth mass extinction. Understanding how conservation efforts are allocated is paramount to effectively protect threatened species. We analyzed similar to 14,600 conservation projects over a 25- y period, revealing substantial taxonomic biases in funding. When matched with formal assessments of species' threat status, several highly threatened groups such as amphibians receive little and ever- decreasin...
• pTDP-43 levels correlate with cell type-specific molecular alterations in the prefrontal cortex of C9orf72 ALS/FTD patients AI翻译
  作者：Wang, Hsiao-Lin V.; Xiang, Jian - Feng; Yuan, Chenyang; Veire, Austin M.; Gendron, Tania F.; Murray, Melissa E.; Tarse, Malu G.; Hu, Jian; Gearing, Marla; Glass, Jonathan D.; Jin, Peng; Corces, Victor G.; Mceachin, Zachary T.
  作者单位：Emory University; Emory University; Emory University; Rollins School Public Health; Mayo Clinic; State University System of Florida; University of Florida; State University System of Florida; University of Florida; Emory University; Emory University
  摘要：Repeat expansions in the C9orf72 gene are the most common genetic cause of amyotrophic lateral sclerosis and familial frontotemporal dementia (ALS/FTD). To identify molecular defects that take place in the dorsolateral frontal cortex of patients with C9orf72ALS/FTD, we compared healthy controls with C9orf72ALS/FTD donor samples staged based on the levels of cortical phosphorylated TAR DNA binding protein (pTDP-43), a neuropathological hallmark of disease progression. We identified distinct mol...
• Erythroid progenitor cell-mediated spleen-tumor interaction deteriorates cancer immunity AI翻译
  作者：Wu, Zhi- Zhong; Deng, Wei- Wei; Zhu, Su- Wen; Wang, Wen - Da; Wang, Shuo; Yang, Qi- Chao; Li, Hao; Mao, Liang; Chen, Wanjun; Sun, Zhi- Jun
  作者单位：Wuhan University; Wuhan University; National Institutes of Health (NIH) - USA; NIH National Institute of Dental & Craniofacial Research (NIDCR)
  摘要：Understanding both local and systemic immunity is essential to optimizing the effectiveness of immunotherapy. However, the dynamic alterations in systemic immunity during tumor development are yet to be clearly defined. Here, we identified a previously unrecognized connection that bridges the interaction between the spleen and tumor through erythroid progenitor cells (EPCs), which suppress tumor immunity and promote tumor progression. We performed the single- cell RNA-seq and RNA-seq to demons...
• S- Nitrosylation of CRTC1 in Alzheimer's disease impairs CREB- dependent gene expression induced by neuronal activity AI翻译
  作者：Zhang, Xu; Vlkolinsky, Roman; Wu, Chongyang; Dolatabadi, Nima; Scott, Henry; Prikhodko, Olga; Zhang, Andrew; Blanco, Mayra; Lang, Nhi; Pina-Crespo, Juan; Nakamura, Tomohiro; Roberto, Marisa; Lipton, Stuart A.
  作者单位：Scripps Research Institute; Scripps Research Institute; Scripps Research Institute; University of California System; University of California San Diego
  摘要：cAMP response element- binding protein (CREB)- regulated transcription coactivator 1 (CRTC1) plays an important role in synaptic plasticity, learning, and long- term memory formation through the regulation of neuronal activity- dependent gene expression, and CRTC1 dysregulation is implicated in Alzheimer's disease (AD). Here, we show that increased S- nitrosylation of CRTC1 (forming SNO- CRTC1), as seen in cell- based, animal- based, and human- induced pluripotent stem cell (hiPSC)- derived ce...
• Radiation- induced cellular plasticity primes glioblastoma for forskolin- mediated differentiation AI翻译
  作者：He, Ling; Azizad, Daria; Bhat, Kruttika; Ioannidis, Angeliki; Hoffmann, Carter J.; Arambula, Evelyn; Eghbali, Mansoureh; Bhaduri, Aparna; Kornblum, Harley I.; Pajonk, Frank
  作者单位：University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California Los Angeles Medical Center; University of California System; UCLA Jonsson Comprehensive Cancer Center; University of California Los Angeles; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA
  摘要：Glioblastoma (GBM) is the deadliest brain cancer in adults, and all patients succumb to the tumor. While surgery followed by chemoradiotherapy delays disease progression, these treatments do not lead to tumor control, and targeted therapies or biologics have failed to further improve survival. Utilizing a transient radiation- induced state of multipotency, we used the adenylcyclase activator forskolin to alter the fate of irradiated glioma cells. The effects of the combined treatment on neuron...
• 3A or not 3A: Cytidine deaminases in the etiology of the CAG- repeat expansion diseases AI翻译
  作者：Usdin, Karen
  作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
• The modern pattern of insect herbivory predates the advent of angiosperms by 60 My AI翻译
  作者：Xiao, Lifang; Chen, Liang; Labandeira, Conrad C.; Azevedo-Schmidt, Lauren; Wang, Yongjie; Ren, Dong
  作者单位：Guangdong Academy of Sciences; Institute of Zoology, Guangdong Academy of Sciences; Capital Normal University; Smithsonian Institution; Smithsonian National Museum of Natural History; University System of Maryland; University of Maryland College Park; University System of Maryland; University of Maryland College Park; University of California System; University of California Davis
  摘要：Modern ecosystems display complex associations of plants-insects that underwent a long evolutionary process since the appearance of mid- Paleozoic vascular plants. Although several major hypotheses explain the evolution of these plant-insect associations, the initial pattern of modern insect herbivory is poorly understood. To understand the antiquity of modern patterns of terrestrial arthropod herbivory, functional feeding group-damage type (FFG- DT) data were used to analyze a 305 My interval...
• A spectral machine learning approach to derive central aortic pressure waveforms from a brachial cuff AI翻译
  作者：Tamborini, Alessio; Aghilinejad, Arian; Gharib, Morteza
  作者单位：California Institute of Technology
  摘要：Analyzing cardiac pulse waveforms offers valuable insights into heart health and cardiovascular disease risk, although obtaining the more informative measurements from the central aorta remains challenging due to their invasive nature and limited noninvasive options. To address this, we employed a laboratory- developed cuff device for high- resolution pulse waveform acquisition and constructed a spectral machine learning model to nonlinearly map the brachial wave components to the aortic site....
• No evidence for Peto's paradox in terrestrial vertebrates AI翻译
  作者：Butler, George; Baker, Joanna; Amend, Sarah R.; Pienta, Kenneth J.; Venditti, Chris
  作者单位：University of London; University College London; Johns Hopkins University; Johns Hopkins Medicine; University of Reading
  摘要：Larger, longer- lived species are expected to have a higher cancer prevalence compared to smaller, shorter- lived species owing to the greater number of cell divisions that occur during their lifespan. Yet, to date, no evidence has been found to support this expectation, and no association has been found between cancer prevalence and body size across species-a phenomenon known as Peto's paradox. Specifically, while anticancer mechanisms have been identified for individual species, wider phylog...