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作者：Cheng, Yang; Wang, Xuesong; Ding, Yike; Zhang, Houhong; Jia, Zhenyu; Raikhel, Alexander S.
作者单位：University of California System; University of California Riverside; University of California System; University of California Riverside; Yangzhou University; University of California System; University of California Riverside; University of California System; University of California Riverside
摘要：Female mosquitoes are vectors of many devastating human diseases because they require blood feeding to initiate reproduction. Thus, elucidation of molecular mechanisms managing female mosquito reproduction is essential. Although the regulation of gene expression during the mosquito gonadotrophic cycle has been studied in detail, how this process is controlled at the chromatin level remains unclear. Chromatin must be accessible for transcription factors (TFs) governing gene expression. A specia...
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作者：Hasaien, Jiazila; Wu, Yanling; Shi, Mengzhu; Zhai, Yanni; Wu, Qiong; Liu, Zheng; Zhou, Yi; Chen, Xianhui; Zhao, Jimin
作者单位：Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Physics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Tsinghua University; Songshan Lake Materials Laboratory
摘要：Charge density wave (CDW) material 1T- TaS2 was proposed as a quantum spin liquid candidate, on which a cluster Mott insulator comes into being below the transition temperature. We report an experimental ultrafast generation and detection of the coherent amplitude mode (AM) of its CDW state. A salient feature emerges: The coherent CDW mode AM exhibits an unusual T3.56 temperature dependence below 65 K, in addition to the T2 temperature dependence observed in the 65 to 200 K range. This behavio...
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作者：Cheng, Xuanbing; Li, Zongqi; Zhu, Jialun; Wang, Jingyu; Huang, Ruyi; Yu, Lewis W.; Lin, Shuyu; Forman, Sarah; Gromilina, Evelina; Puri, Sameera; Patel, Pritesh; Bahramian, Mohammadreza; Tan, Jiawei; Hojaiji, Hannaneh; Jelinek, David; Voisin, Laurent; Yu, Kristie B.; Zhang, Ao; Ho, Connie; Lei, Lei; Coller, Hilary A.; Hsiao, Elaine Y.; Reyes, Beck L.; Matsumoto, Joyce H.; Lu, Daniel C.; Liu, Chong; Milla, Carlos; Davis, Ronald W.; Emaminejad, Sam
作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California Los Angeles Medical Center; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; Stanford Medicine; Stanford University; Stanford Medicine; Stanford University; University of California System; University of California Los Angeles
摘要：Mimicking metabolic pathways on electrodes enables in vivo metabolite monitoring for decoding metabolism. Conventional in vivo sensors cannot accommodate underlying complex reactions involving multiple enzymes and cofactors, addressing only a fraction of enzymatic reactions for few metabolites. We devised a single- wall- carbon- nanotube- electrode architecture supporting tandem metabolic pathway-like reactions linkable to oxidoreductase- based electrochemical analysis, making a vast majority ...
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作者：Meng, Luming; Sheong, Fu Kit; Luo, Qiong
作者单位：South China Agricultural University; Guangdong Laboratory for Lingnan Modern Agriculture; Hong Kong University of Science & Technology; South China Normal University
摘要：DNA is heterogeneously packaged into chromatin, which is further organized into topologically associating domains (TADs) with sharp boundaries. These boundary locations are critical for genome regulation. Here, we explore how the distribution of DNA- packing density across chromatin affects the TAD boundary locations. We develop a polymer- physics- based model that utilizes DNA accessibility data to parameterize DNA- packing density along chromosomes, treating them as heteropolymers, and simul...
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作者：Oluoch, Peter O.; Koh, Eun- Ik; Proulx, Megan K.; Reames, Charlotte J.; Papavinasasundaram, Kadamba G.; Murphy, Kenan C.; Zimmerman, Matthew D.; Dartois, Veronique; Sassetti, Christopher M.
作者单位：University of Massachusetts System; University of Massachusetts Worcester
摘要：Successful tuberculosis therapy requires treatment with an unwieldy multidrug combi- nation for several months. Thus, there is a growing need to identify novel genetic vul- nerabilities that can be leveraged to develop new, more effective antitubercular drugs. Consequently, recent efforts to optimize tuberculosis (TB) therapy have exploited Mycobacterium tuberculosis (Mtb) chemical genetics to identify pathways influencing antibiotic efficacy, novel mechanisms of antibiotic action, and new tar...
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作者：Domenzain, Ivan; Lu, Yao; Wang, Haoyu; Shi, Junling; Lu, Hongzhong; Nielsen, Jens
作者单位：Chalmers University of Technology; Chalmers University of Technology; Northwest A&F University - China; Shanghai Jiao Tong University; Chinese Academy of Sciences; Dalian Institute of Chemical Physics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Northwestern Polytechnical University
摘要：Development of efficient cell factories that can compete with traditional chemical production processes is complex and generally driven by case- specific strategies, based on the product and microbial host of interest. Despite major advancements in the field of metabolic modeling in recent years, prediction of genetic modifications for increased production remains challenging. Here, we present a computational pipeline that leverages the concept of protein limitations in metabolism for predicti...
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作者：Chou, Yu - Shu; Logeswaran, Dhenugen; Chow, Chi - Nga; Dunn, Phoebe L.; Podlevsky, Joshua D.; Liu, Tianxiang; Akhter, Khadiza; Chen, Julian J. - L.
作者单位：Arizona State University; Arizona State University-Tempe; Arizona State University; Arizona State University-Tempe; United States Department of Energy (DOE); Sandia National Laboratories
摘要：Telomerase elongates telomeres to maintain chromosome stability in most eukaryotes. Despite extensive studies across eukaryotic kingdoms, the telomerase holoenzyme in arthropods remains poorly understood. In this study, we purify the telomerase ribonucleoprotein complex from the lepidopteran insect Spodoptera frugiperda (fall army- worm) and identify a copurified 135- nucleotide telomerase RNA (TR) component. This miniature S. frugiperda TR (sfTR), the smallest TR known to date, retains a univ...
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作者：Crossley, Michael; Simon, Anna; Marathe, Shashidhara; Rau, Christoph; Roth, Arnd; Marra, Vincenzo; Staras, Kevin
作者单位：University of Sussex; University of London; University College London; Diamond Light Source
摘要：Molluscan brains are composed of morphologically consistent and functionally interrogable neurons, offering rich opportunities for understanding how neural circuits drive behavior. Nonetheless, detailed component- level CNS maps are often lacking, total neuron numbers are unknown, and organizational principles remain poorly defined, limiting a full and systematic characterization of circuit operation. Here, we establish an accessible, generalizable approach, harnessing synchrotron X- ray tomog...
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作者：Guo, Xiao; Dong, Xinyu; Zou, Guijin; Zhang, Haoqi; Zeng, Kaiyang; Gao, Huajian; Zhai, Wei
作者单位：National University of Singapore; Nanyang Technological University; Tsinghua University
摘要：Mimicking hierarchical structures found in nature, such as nacre and tendon, has led to remarkable successes in the creation of biomimetic materials with exceptional properties. The depth of knowledge derived from nature extends far beyond mere trial- and- error fabrication by providing deep insights into the toughening mechanisms that are integral to natural materials. A key challenge is understanding how these toughening mechanisms can be effectively translated into biomimetic materials. Her...
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作者：Rusconea, Guido Alberto Gnecchi-; Racz, Zsofia; Liccardo, Salvatore; Lee, Juhyeon; Huang, Yilei; Traverso, Luca; Radzeviciute, Rita; Hajnal, Zsuzsanna; Szecsenyi-Nagy, Anna; Gyuris, Balazs; Mateovics-Laszlo, Orsolya; Bernert, Zsolt; Szeniczey, Tamas; Hajdu, Tamas; Meszaros, Boglarka; Balint, Marianna; Mende, Balazs Gusztav; Miller, Bryan; Samashev, Zainolla; Childebayeva, Ainash; Djansugurova, Leyla; Geary, Patrick; Ringbauer, Harald; Vida, Tivadar; Jeong, Choongwon; Pohl, Walter; Krause, Johannes; Hofmanova, Zuzana
作者单位：Max Planck Society; Masaryk University; Eotvos Lorand University; University of Vienna; Austrian Academy of Sciences; Seoul National University (SNU); Seoul National University (SNU); Eotvos Lorand University; Eotvos Lorand University; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Texas System; University of Texas Austin; Institute of Zoology in Kazakhstan; Institute for Advanced Study - USA
摘要：The Huns appeared in Europe in the 370s, establishing an Empire that reshaped West Eurasian history. Yet until today their origins remain a matter of extensive debate. Traditional theories link them to the Xiongnu, the founders of the first nomadic empire of the Mongolian steppe. The Xiongnu empire dissolved, however, similar to 300 y before the Huns appeared in Europe, and there is little archaeological and historical evidence of Huns in the steppe during this time gap. Furthermore, despite t...
