2025

最新文章

• Twinfilin is a nonprocessive depolymerase which synergizes with formin to dramatically accelerate actin filament uncapping by 300-fold AI翻译
  作者：Reddy, Vishal; Arya, Ankita; Shekhar, Shashank
  作者单位：Emory University; Emory University
  摘要：For over four decades, our understanding of cellular actin dynamics has been guided by the concept of treadmilling. However, this paradigm has been challenged by the evidence that twinfilin can uncap and promote depolymerization of filament barbed ends, though its precise mechanism remains debated. Using single-molecule microscopy and microfluidics-assisted TIRF imaging, we demonstrate that twinfilin transiently associates with barbed ends for similar to 0.2 to 0.5 s, acting as a nonprocessive...
• The fate of South America's endemic mammalian fauna in response to the most dramatic Cenozoic climate disruption AI翻译
  作者：Buffan, Lucas; Condamine, Fabien L.; Stutz, Narla S.; Pujos, Francois; Antoine, Pierre - Olivier; Marivaux, Laurent
  作者单位：Institut de Recherche pour le Developpement (IRD); Universite de Montpellier; Centre National de la Recherche Scientifique (CNRS); Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)
  摘要：Around 34 Mya, the Eocene-Oligocene transition (EOT) marked the most dramatic global climatic cooling of the Cenozoic. On a planetary scale, paleontological evidence suggests that this transition was associated with major faunal turnovers, sometimes even regarded as a mass extinction crisis. In South America, there is no consensus on the response of the endemic mammals to this transition. Here, using a vetted fossil dataset and cutting-edge Bayesian methods, we analyzed the dynamics of South A...
• Unusual magnetotransport in twisted bilayer graphene from strain-induced open Fermi surfaces (vol 120, e2307151120, 2023) AI翻译
  作者：Wang, Xiaoyu; Finney, Joe; Sharpe, Aaron L.; Rodenbach, Linsey K.; Hsueh, Connie L.; Watanabe, Kenji; Taniguchi, Takashi; Kastner, M. A.; Vafek, Oskar; Goldhaber-Gordon, David
• Dysregulation of MYBL2 impairs extravillous trophoblast lineage development and function, contributing to recurrent spontaneous abortion AI翻译
  作者：Wu, Zhi-Hong; Yi, Cen; Chen, En-Xiang; Xu, Jia-Qi; Li, Cong; Yao, Lu; Li, Fang-Fang; Fu, Li-Juan; Ge, Lu-Xing; Wang, Ying-Xiong; Xie, You-Long; Ding, Yu-Bin; Tang, Jing
  作者单位：Chongqing Medical University; Chongqing Medical University; Chongqing Medical University; Changsha Medical University
  摘要：Recurrent spontaneous abortion (RSA) is a pregnancy- related condition characterized by a complex etiology. While placental trophoblast dysfunction is strongly associated with the development and progression of RSA, the underlying molecular mechanisms remain poorly understood. In this study, we observed a significant decrease in the expression and the placentas of abortion- prone (AP) mice. Utilizing human trophoblast stem cells (hTSCs), we identified MYBL2 as a critical regulator of hTSCs ste...
• Primed 3D injectable microniches enabling low-dosage cell therapy for critical limb ischemia (vol 111, pg 13511, 2014) AI翻译
  作者：Li, Yaqian; Liu, Wei; Liu, Fei; Zeng, Yang; Zuo, Simin; Feng, Siyu; Qi, Chunxiao; Wang, Bingjie; Yan, Xiaojun; Khademhosseini, Ali; Bai, Jing; Du, Yanan
• The multifaceted roles of the transcriptional coactivator TAZ in extravillous trophoblast development of the human placenta AI翻译
  作者：Meinhardt, Gudrun; Waldhaeusl, Hanna; Lackner, Andreas I.; Waechter, Jasmin; Maxian, Theresa; Hoebler, Anna-Lena; Vondra, Sigrid; Kunihs, Victoria; Saleh, Leila; Haslinger, Peter; Kiraly, Peter; Szilagyi, Andras; Than, Nandor G.; Pollheimer, Juergen; Haider, Sandra; Knoefler, Martin
  作者单位：Medical University of Vienna; Medical University of Vienna; Semmelweis University
  摘要：Insights into the molecular processes that drive early development of the human placenta is crucial for our understanding of pregnancy complications such as preeclampsia and fetal growth restriction, since defects in maturation of its epithelial cell, the trophoblast, have been detected in the severe forms of these diseases. However, key regulators specifying the differentiated trophoblast subtypes of the placenta are only slowly emerging. By using diverse trophoblast cell models, we herein sh...
• Global subnational estimates of migration of scientists reveal large disparities in internal and international flows AI翻译
  作者：Akbaritabar, Aliakbar; Danko, Maciej J.; Zhao, Xinyi; Zagheni, Emilio
  作者单位：Max Planck Society; University of Oxford; Max Planck Society
  摘要：Researchers are key contributors to innovation. Their migration results in talent circulation and recombination of ideas. Due to data shortage, little is known about subnational mobility of scientists and the interrelationships between their internal and international migration patterns. We used data on 30+ million Scopus publications of 19+ million authors to infer migration from changes in affiliations. Our publicly shared database of global subnational estimates of migration reveals relevan...
• Pulsatile basal gene expression as a fitness determinant in bacteria AI翻译
  作者：Jain, K.; Hauschild, R.; Bochkareva, O. O.; Roemhild, R.; Tkacik, G.; Guet, C. C.
  作者单位：Institute of Science & Technology - Austria
  摘要：Active regulation of gene expression, orchestrated by complex interactions of activators and repressors at promoters, controls the fate of organisms. In contrast, basal expression at uninduced promoters is considered to be a dynamically inert mode of nonfunctional promoter leakiness, merely a byproduct of transcriptional regulation. Here, we investigate the basal expression mode of the mar operon, the main regulator of intrinsic multiple antibiotic resistance in Escherichia coli, and link its ...
• Structural basis of the cysteinyl leukotriene receptor type 2 activation by LTD4 AI翻译
  作者：Jiang, Mengting; Xu, Youwei; Luan, Xiaodong; Wu, Kai; Li, Zhen; Xu, H. Eric; Zhang, Shuyang; Jiang, Yi; Yin, Wanchao
  作者单位：Lingang Laboratory; ShanghaiTech University; Nanjing University of Chinese Medicine; Chinese Academy of Sciences; Shanghai Institute of Materia Medica, CAS; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Peking Union Medical College Hospital; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College Hospital; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Shanghai Institute of Materia Medica, CAS
  摘要：The G protein-coupled cysteinyl leukotriene receptor CysLT2R plays intricate roles in the physiology and pathogenesis of inflammation-related processes. It has garnered increasing attention as a potential therapeutic target for atopic asthma, brain injury, central nervous system disorders, and various types of cancer. In this study, we present the cryo-electron microscopy structure of the cysteinyl leukotriene D4 (LTD4)-bound human CysLT2R in complex with a G alpha q protein, adopting an activ...
• Motion artifact-controlled micro-brain sensors between hair follicles for persistent augmented reality brain-computer interfaces AI翻译
  作者：Kim, Hodam; Kim, Ju Hyeon; Lee, Yoon Jae; Lee, Jimin; Han, Hyojeong; Yi, Hoon; Kim, Hyeonseok; Kim, Hojoong; Kang, Tae Woog; Chung, Suyeong; Ban, Seunghyeb; Lee, Byeongjun; Lee, Haran; Im, Chang-Hwan; Cho, Seong J.; Sohn, Jung Woo; Yu, Ki Jun; Kang, June; Yeo, Woon-Hong
  作者单位：University System of Georgia; Georgia Institute of Technology; University System of Georgia; Georgia Institute of Technology; Yonsei University; Inha University; University System of Georgia; Georgia Institute of Technology; Hanyang University; Kumoh National University Technology; Chungnam National University; Kumoh National University Technology; Yonsei University; University System of Georgia; Georgia Institute of Technology; Emory University; University System of Georgia; Georgia Institute of Technology
  摘要：Modern brain-computer interfaces (BCI), utilizing electroencephalograms for bidirectional human-machine communication, face significant limitations from movement-vulnerable rigid sensors, inconsistent skin-electrode impedance, and bulky electronics, diminishing the system's continuous use and portability. Here, we introduce motion artifact-controlled micro-brain sensors between hair strands, enabling ultralow impedance density on skin contact for long-term usable, persistent BCI with augmented...