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作者：Zhang, Xiaoyu; Liu, Yan; Wang, Ning
作者单位：University of Kansas; University of Kansas Medical Center; University of Kansas; University of Kansas Medical Center; University of Kansas; University of Kansas Medical Center
摘要：Male germ cells, which are responsible for producing millions of genetically diverse sperm through meiosis in the testis, rely on lactate as their central energy metabolite. Recent study has revealed that lactate induces epigenetic modification in cells through histone lysine lactylation. Here, we report dynamic histone lactylation at histone H4- lysine 5 (K5),- K8, and- K12 during meiosis prophase I in mouse spermatogenesis. By profiling the genome-wide occupancy of histone H4- K8 lactylation...
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作者：Fan, Siyu; Dong, Shuling; Yao, Weijing; Zhang, Yi; Fan, Mingzhu; Feng, Shan; Wu, Choufei; Zhang, Liqin; Yi, Cong
作者单位：Zhejiang University; Zhejiang University; Huzhou University; Westlake University
摘要：Mec1 plays an essential role in both the DNA damage response and glucose starvation- induced autophagy. We recently reported that Mec1 regulates glucose starvation-induced autophagy through its direct binding to Atg13. However, the role of Mec1's kinase activity in autophagy remains unclear. In this study, we demonstrate that the kinase activity of Mec1 is required for glucose starvation-induced autophagy by regulating the phagophore assembly site (PAS) recruitment of Atg9 vesicles. Mechanisti...
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作者：Willis, Katie; Burt, Austin
作者单位：Imperial College London
摘要：While the release of sterile males has been highly successful in suppressing some pest populations, it is impractical for many species due to the males disappearing after a single generation, necessitating large, repeated releases to maintain sufficient impact. Synthetic gene drives promise more efficient approaches since they can increase in frequency from rare, yet this also allows them to spread across a landscape, which may not always be desired. Between these two extremes are selectively ...
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作者：Fan, Wenxiao; Zhou, Junming; Jiang, Xiaodong; Zhang, Huan; Mi, Mei; Yuan, Peng; Dong, Yanhui; Liu, Dong; Wei, Yanfu; Peckmann, Joern
作者单位：Guangdong University of Technology; Southern Marine Science & Engineering Guangdong Laboratory; Southern Marine Science & Engineering Guangdong Laboratory (Guangzhou); Chinese Academy of Sciences; Guangzhou Institute of Geochemistry, CAS; Ministry of Natural Resources of the People's Republic of China; Second Institute of Oceanography, Ministry of Natural Resources; Macau University of Science & Technology; University of Hamburg
摘要：As an essential micronutrient, phosphorus plays a key role in oceanic biogeochemistry, with its cycling intimately connected to the global carbon cycle and climate change. Authigenic carbonate fluorapatite (CFA) has been suggested to represent a significant phosphorus sink in the deep ocean, but its formation mechanisms in oceanic low- productivity settings remain poorly constrained. Applying X- ray absorption near edge structure, transmission electron microscopy, and laser ablation inductivel...
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作者：Gigerenzer, Gerd; Allen, Colin; Gaillard, Stefan; Goldstone, Robert L.; Haaf, Julia; Holmes, William R.; Kashima, Yoshihisa; Motz, Benjamin; Musslick, Sebastian; Stefan, Angelika
作者单位：Max Planck Society; University of California System; University of California Santa Barbara; Radboud University Nijmegen; Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington; University of Potsdam; University of Melbourne; Brown University; University of Liverpool
摘要：Funding of curiosity- driven science is the lifeblood of scientific and technological innovation. Various models of funding allocation became institutionalized in the 20th century, shaping the present landscape of research funding. There are numerous reasons for scientists to be dissatisfied with current funding schemes, including the imbalance between funding for curiosity- driven and mission- directed research, regional and country disparities, path- dependency of who gets funded, gender and...
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作者：Duan, Yueran; Memon, Shahan Ali; Alshebli, Bedoor; Guan, Qing; Holme, Petter; Lrahwan, Tala
作者单位：China University of Geosciences; Aalto University; New York University; New York University Abu Dhabi; University of Washington; University of Washington Seattle; China University of Geosciences; Kobe University; New York University; New York University Abu Dhabi
摘要：Postdoctoral training is a career stage often described as a demanding and anxiety- laden time when many promising PhDs see their academic dreams slip away due to circumstances beyond their control. We use a unique dataset of academic publishing and careers to chart the more or less successful postdoctoral paths. We build a measure of academic success on the citation patterns two to five years into a faculty career. Then, we monitor how students' postdoc positions-in terms of relocation, chang...
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作者：Zhang, Yaqing; Wu, Rihan; Shahjahan, Md; Yang, Canchai; Pyeon, Dohun; Harel, Elad
作者单位：Michigan State University; Michigan State University
摘要：The natural vibrational frequencies of biological particles such as viruses and bacteria encode critical information about their mechanical and biological states as they interact with their local environment and undergo structural evolution. However, detecting and tracking these vibrations within a biological context at the single particle level has remained elusive. In this study, we track the vibrational motions of single, unlabeled virus particles under ambient conditions using ultrafast sp...
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作者：Angeli, Peter A.; Dinicola, Lauren M.; Saadon-Grosman, Noam; Eldaief, Mark C.; Buckner, Randy L.
作者单位：Harvard University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital
摘要：The hippocampus possesses anatomical differences along its long axis. Here, we explored the functional specialization of the human hippocampal long axis using network- anchored precision functional MRI in two independent datasets (N = 11 and N = 9) paired with behavioral analysis (N = 266 and N = 238). Functional connectivity analyses demonstrated that the anterior hippocampus was preferentially correlated with a cerebral network associated with remembering, while the posterior hippocampus sel...
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作者：Whetsel, Charles; Levine, Joel S.; Hoffman, Stephen J.; Luckey, Clare M.; Watts, Kevin D.; Antonsen, Erik L.
作者单位：California Institute of Technology; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); Aerospace Corporation - USA; National Aeronautics & Space Administration (NASA); NASA Johnson Space Center; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital
摘要：One of the most surprising and important findings of the first human landings on the Moon was the discovery of a very fine layer of lunar dust covering the entire surface of Moon along with the negative impacts of this dust on the well- being and operational effectiveness of the astronauts, their equipment, and instrumentation. The United States is now planning for human missions to Mars, a planet where dust can also be expected to be ubiquitous for many or most landing sites. For these missio...
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作者：Liu, Xing; Liu, Tianxu; Shao, Zhen; Xiong, Xiaoyan; Qi, Shuhui; Guan, Junyong; Wang, Menghang; Tang, Yan-Dong; Feng, Zongdi; Wang, Lin; Yin, Xin
作者单位：Chinese Academy of Agricultural Sciences; Harbin Veterinary Research Institute, CAAS; Peking University; Peking University; Wageningen University & Research; University System of Ohio; Ohio State University; Nationwide Childrens Hospital; Research Institute at Nationwide Children's Hospital; Center for Vaccines & Immunity; University System of Ohio; Ohio State University
摘要：Historically considered to be nonenveloped, hepatitis E virus (HEV), an important zoonotic pathogen, has recently been discovered to egress from infected cells as quasi- enveloped virions. These quasi- enveloped virions circulating in the blood are resistant to neutralizing antibodies, thereby facilitating the stealthy spread of infection. Despite abundant evidence of the essential role of the HEV- encoded ORF3 protein in quasi- enveloped virus formation, the underlying mechanism remains uncle...
