-
作者：Zhang, Juan; Zhang, Hui-Lin; Xu, Xin-Rong; Feng, Yan-Li; Zhu, Qi-Meng; Morisseau, Christophe; Qiu, Feng; Hammock, Bruce D.; Sun, Cheng-Peng
作者单位：Tianjin University of Traditional Chinese Medicine; University of California System; University of California Davis
摘要：Neuroinflammation is a complex immunological phenomenon characterized by a dysregulated inflammatory response in the central nervous system (CNS) that can be triggered by various pathological injuries, such as toxins, which are involved in Parkinson's and Alzheimer's diseases (PD and AD), therefore, suppressing neuroinflammation serves as an effective treatment for CNS diseases. Herein, we found that natural soluble epoxide hydrolase (sEH) inhibitor 1-O-acetyl-4R,6S-britannilactone (AB) regula...
-
作者：Dablander, Fabian; Lange, Florian; Brick, Cameron; Aron, Adam R.
作者单位：University of Amsterdam; University of Amsterdam; KU Leuven; University of Amsterdam; University of California System; University of California San Diego
-
作者：Lord, Edana; Feinauer, Isabelle S.; Soares, Andre E. R.; Lagerholm, Vendela K.; Naesvall, Karin; Ersmark, Erik; Olsen, Remi- Andre; Prost, Stefan; Kuzmina, Elena A.; Smirnov, Nickolay G.; Stewart, John R.; V. Knul, Monika; Noiret, Pierre; Germonpre, Mietje; Ehrich, Dorothee; Pokrovsky, Ivan; Fedorov, Vadim B.; V. Goropashnaya, Anna; Dalen, Love; Diez-del-Molino, David
作者单位：Swedish Museum of Natural History; Stockholm University; Swedish Museum of Natural History; Uppsala University; Stockholm University; Wellcome Trust Sanger Institute; Stockholm University; University of Vienna; South African National Biodiversity Institute; Russian Academy of Sciences; Institute of Plant & Animal Ecology of the Russian Academy of Sciences; Bournemouth University; University of Winchester; University of Liege; Royal Belgian Institute of Natural Sciences; UiT The Arctic University of Tromso; Max Planck Society; University of Alaska System; University of Alaska Fairbanks
摘要：The Norwegian lemming (Lemmus lemmus) is a small rodent distributed across the Fennoscandian mountain tundra and the Kola Peninsula. The Norwegian lemming likely evolved during the Late Pleistocene and inhabited Fennoscandia shortly prior to the Last Glacial Maximum. However, the exact timing and origins of the species, and its phylogenetic position relative to the closely related Siberian lemming (Lemmus sibiricus) remain disputed. Moreover, the presence of ancient or contemporary gene flow b...
-
作者：Meister, Toni Luise; Nocke, Maximilian K.; Heinen, Natalie; Burkard, Thomas L.; Brueggemann, Yannick; Westhoven, Saskia; Trueb, Bettina; Ebert, Nadine; Thomann, Lisa; Lubieniecki, Krzysztof P.; Lubieniecka, Joanna M.; Doering, Kristina; Herrmann, Maike; Haid, Sibylle; Pietschmann, Thomas; Wiegmann, Bettina; Tao, Ronny; Pfefferle, Susanne; Addo, Marylyn M.; Thiel, Volker; Drexler, Ingo; Babel, Nina; Nguyen, Huu Phuc; Brown, Richard J. P.; Todt, Daniel; Steinmann, Elike; Pfaender, Stephanie
作者单位：Ruhr University Bochum; University of Hamburg; University Medical Center Hamburg-Eppendorf; Leibniz Association; Bernhard Nocht Institut fur Tropenmedizin; German Center for Infection Research; Ruhr University Bochum; University of Bern; Ruhr University Bochum; Paul Ehrlich Institute; Helmholtz Association; Helmholtz-Center for Infection Research; Hannover Medical School; Hannover Medical School; Hannover Medical School; Heinrich Heine University Dusseldorf; University of Hamburg; University Medical Center Hamburg-Eppendorf; Leibniz Association; Bernhard Nocht Institut fur Tropenmedizin; University of Bern; Ruhr University Bochum; St. Marien Hospital; Ruhr University Bochum; St. Marien Hospital; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; German Center for Infection Research; University of Lubeck
摘要：Mycophenolic acid (MPA) is commonly used in immunosuppressive regimens following solid organ transplantation. We demonstrate that MPA treatment reproducibly inhibits the replication of a range of viruses, including severe respiratory syndrome coronavirus 2 (SARS-CoV-2). Mechanistically, we identified cellular guanosine triphosphate pool depletion as a key mediator of this antiviral effect. Strikingly, this inhibition can be overcome which was correlated with the emergence of three breakthrough...
-
作者：Xu, Wenbin; Sanspeur, Rohan Yuri; Kolluru, Adeesh; Deng, Bowen; Harrington, Peter; Farrell, Steven; Reuter, Karsten; Kitchin, John R.
作者单位：United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Carnegie Mellon University; Max Planck Society; Fritz Haber Institute of the Max Planck Society
摘要：The screening and discovery of magnetic materials are hindered by the computational cost of first-principles density-functional theory (DFT) calculations required to find the ground state magnetic ordering. Although universal machine-learning interatomic potentials (uMLIPs), also known as atomistic foundation models, offer high-fidelity models of many atomistic systems with significant speedup, they currently lack the inputs required for predicting magnetic ordering. In this work, we present a...
-
作者：Scheres, Sjors H. W.
作者单位：MRC Laboratory Molecular Biology
-
作者：Hunt, Robert; Camassa, Roberto; McLaughlin, Richard M.; Harris, Daniel M.
作者单位：Brown University; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine
摘要：The vertical transport of solid material in a stratified medium is fundamental to a number of environmental applications, with implications for the carbon cycle and nutrient transport in marine ecosystems. In this work, we study the diffusion-limited settling of highly porous particles in a density-stratified fluid through a combination of experiment, analysis, and numerical simulation. By delineating and appealing to the diffusion-limited regime wherein buoyancy effects due to mass adaptation...
-
作者：Liang, Chun; Zhai, Tian-Ying; Chen, Jin; Fang, Shu; Zhu, Yan; Liu, Li-Man; Yu, Ning; Zhao, Hong-Bo
作者单位：Yale University; University of Kentucky
摘要：Negative feedback of the cochlear efferent system plays a critical role in control of hearing sensitivity and protection from noise trauma. Type II auditory nerves (ANs) innervate outer hair cells (OHCs) in the cochlea and provide an input to the cochlear efferent system to achieve hearing sensitivity controlling and protection; in particular, medial olivocochlear efferent nerves innervate OHCs to control OHC electromotility, which is an active cochlear amplifier in mammals. However, little is...
-
作者：Manthey, Christin; Metcalf, C. Jessica E.; Monaghan, Michael T.; Steiner, Ulrich K.; Rolff, Jens
-
作者：Hu, Chenyang; Chen, Zhenshan; Liu, Pengfei; Zhang, Wei; He, Xi; Bosch, Darrell
作者单位：Virginia Polytechnic Institute & State University; University of Rhode Island
摘要：As the renewable energy transition continues into less receptive communities, local opposition is expected to intensify, potentially slowing the process. Since the local impacts are neither well quantified nor widely recognized, we lack policies and common practices to mitigate the potential associated welfare loss in affected communities. Based on a nationwide dataset combining property transactions and large-scale solar photovoltaic (LSSPV) sites, we analyze the heterogeneous effects of LSSP...
