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作者：Savitsky, Zack
摘要：A feisty Sun threatens satellites and electric grids, highlighting need for better forecasts
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作者：Macklin, M. G.; Thomas, C. J.; Mudbhatkal, A.; Brewer, P. A.; Hudson-Edwards, K. A.; Lewin, J.; Scussolini, P.; Eilander, D.; Lechner, A.; Owen, J.; Bird, G.; Kemp, D.; Mangalaa, K. R.
作者单位：University of Lincoln; Massey University; La Trobe University; University of Namibia; Aberystwyth University; University of Exeter; University of Exeter; Vrije Universiteit Amsterdam; Deltares; Vrije Universiteit Amsterdam; University of the Free State; Bangor University; University of Queensland; Ministry of Earth Sciences (MoES) - India
摘要：An estimated 23 million people live on floodplains affected by potentially dangerous concentrations of toxic waste derived from past and present metal mining activity. We analyzed the global dimensions of this hazard, particularly in regard to lead, zinc, copper, and arsenic, using a georeferenced global database detailing all known metal mining sites and intact and failed tailings storage facilities. We then used process-based and empirically tested modeling to produce a global assessment of ...
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作者：Offord, Catherine
摘要：Researchers say they felt pushed into signing away thousands of dollars for services they ultimately didn't want
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作者：Cheng, Jun; Novati, Guido; Pan, Joshua; Bycroft, Clare; Zemgulyte, Akvile; Applebaum, Taylor; Pritzel, Alexander; Wong, Lai Hong; Zielinski, Michal; Sargeant, Tobias; Schneider, Rosalia G.; Senior, Andrew W.; Jumper, John; Hassabis, Demis; Kohli, Pushmeet; Avsec, Ziga
作者单位：Alphabet Inc.; DeepMind; Google Incorporated
摘要：The vast majority of missense variants observed in the human genome are of unknown clinical significance. We present AlphaMissense, an adaptation of AlphaFold fine-tuned on human and primate variant population frequency databases to predict missense variant pathogenicity. By combining structural context and evolutionary conservation, our model achieves state-of-the-art results across a wide range of genetic and experimental benchmarks, all without explicitly training on such data. The average ...
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作者：Harris, Katie
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作者：Normile, Dennis
摘要：Sudden revamp would trim basic research spending while boosting biomedical innovation, space, and other fields
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作者：Xia, Yisui; Sonneville, Remi; Jenkyn-Bedford, Michael; Ji, Liqin; Alabert, Constance; Hong, Ye; Yeeles, Joseph T. P.; Labib, Karim P. M.
作者单位：University of Dundee; MRC Laboratory Molecular Biology; Shandong University; University of Dundee; Shenzhen University; Rockefeller University
摘要：Assembly of the CMG (CDC-45-MCM-2-7-GINS) helicase is the key regulated step during eukaryotic DNA replication initiation. Until now, it was unclear whether metazoa require additional factors that are not present in yeast. In this work, we show that Caenorhabditis elegans DNSN-1, the ortholog of human DONSON, functions during helicase assembly in a complex with MUS-101/TOPBP1. DNSN-1 is required to recruit the GINS complex to chromatin, and a cryo-electron microscopy structure indicates that D...
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作者：Porrett, Paige M.
作者单位：University of Alabama System; University of Alabama Birmingham
摘要：When pregnant, maternal immunologic tolerance is required to ensure that the fetus is not rejected by the mother's immune system. This tolerance is achieved by expansion of a subset of CD4(+) T cells with regulatory properties (T-reg cells) that protect against fetal loss (1-3). Maternal T-reg cells develop immunologic memory, which confers fetal-specific protection against complications in subsequent pregnancy (4). Prior studies have suggested that memory T-reg cells are sustained by fetal mi...
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作者：Pouikli, Andromachi; Frezza, Christian
作者单位：University of Cologne; University of Cologne
摘要：The metabolism of cancer cells adapts to meet an increased need for the energy, biosynthesis, and antioxidants required for proliferation, tumor growth, and metastasis (1). Yet, whether this metabolic reprogramming affects the recognition and elimination of cancer cells by immune cells has not been well investigated. On page 1316 of this issue, Mangalhara et al. (2) report a connection between a cancer cell's mitochondrial metabolism and its ability to evoke an immune response in a mouse model...
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作者：Jacobs, Phie
摘要：Half-million-year-old structure unearthed in Zambia may have been a platform, bridge, or house foundation
