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作者：Brainard, Jeffrey
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作者：Brainard, Jeffrey
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作者：Mydlarz, Laura D.; Muller, Erinn M.
作者单位：University of Texas System; University of Texas Arlington; Mote Marine Laboratory & Aquarium
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作者：Appenzeller, Tim
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作者：Gonzalez-Bailon, Sandra; Lazer, David
作者单位：University of Pennsylvania; Northeastern University
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作者：Stokstad, Erik
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作者：Yao, N.; Zhang, Z.; Yu, L.; Hazarika, R.; Yu, C.; Jang, H.; Smith, L. M.; Ton, J.; Liu, L.; Stachowicz, J. J.; Reusch, T. B. H.; Schmitz, R. J.; Johannes, F.
作者单位：University System of Georgia; University of Georgia; Technical University of Munich; Helmholtz Association; GEOMAR Helmholtz Center for Ocean Research Kiel; University of Sheffield; University System of Georgia; University of Georgia; University of California System; University of California Davis
摘要：Molecular clocks are the basis for dating the divergence between lineages over macroevolutionary timescales (similar to 10(5) to 10(8) years). However, classical DNA-based clocks tick too slowly to inform us about the recent past. Here, we demonstrate that stochastic DNA methylation changes at a subset of cytosines in plant genomes display a clocklike behavior. This epimutation clock is orders of magnitude faster than DNA-based clocks and enables phylogenetic explorations on a scale of years t...
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作者：Camelliti, Patrizia; Stuckey, Daniel J.
作者单位：University of Surrey; University of London; University College London
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作者：Enbody, Erik D.; Sendell-Price, Ashley T.; Sprehn, C. Grace; Rubin, Carl-Johan; Visscher, Peter M.; Grant, B. Rosemary; Grant, Peter R.; Andersson, Leif
作者单位：Uppsala University; University of Queensland; Princeton University; Texas A&M University System; Texas A&M University College Station; University of California System; University of California Santa Cruz; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
摘要：A fundamental goal in evolutionary biology is to understand the genetic architecture of adaptive traits. Using whole-genome data of 3955 of Darwin's finches on the Galapagos Island of Daphne Major, we identified six loci of large effect that explain 45% of the variation in the highly heritable beak size of Geospiza fortis, a key ecological trait. The major locus is a supergene comprising four genes. Abrupt changes in allele frequencies at the loci accompanied a strong change in beak size cause...
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作者：Rahimzadeh, Vasiliki; Fogarty, Jennifer; Caulfield, Timothy; Aunon-Chancellor, Serena; Borry, Pascal; Candia, Jessica; Cohen, I. Glenn; Covington, Marisa; Lynch, Holly Fernandez; Greely, Henry T.; Hanlon, Michelle; Hatt, James; Low, Lucie; Menikoff, Jerry; Meslin, Eric M.; Platts, Steven; Ravitsky, Vardit; Ruttley, Tara; Seidler, Rachael D.; Sugarman, Jeremy; Urquieta, Emmanuel; Williams, Michael A.; Wolpe, Paul Root; Donoviel, Dorit; McGuire, Amy L.
作者单位：Baylor College of Medicine; Baylor College of Medicine; University of Alberta; University of Alberta; Louisiana State University System; Louisiana State University Health Sciences Center at Shreveport; Louisiana State University; KU Leuven; Harvard University; National Aeronautics & Space Administration (NASA); University of Pennsylvania; Stanford University; University of Mississippi; National University of Singapore; National Aeronautics & Space Administration (NASA); Universite de Montreal; Harvard University; Harvard Medical School; State University System of Florida; University of Florida; State University System of Florida; University of Florida; Johns Hopkins University; Johns Hopkins University; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Emory University
